ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Peptide
building
blocks
have
been
recently
proposed
for
the
fabrication
of
supramolecular
nanostructures
able
to
encapsulate
and
in
vivo
deliver
drugs
a
different
nature.
The
primary
sequence
design
is
essential
nanostructure
property
modulation,
directing
affecting
affinity
specific
drugs.
For
instance,
presence
positively
charged
residues
lysine
(K)
or
arginine
(R)
could
allow
improving
electrostatic
interactions
and,
turn,
encapsulation
negatively
active
pharmaceutical
ingredients,
including
nucleic
acids.
In
this
context,
here,
we
describe
formulation
multiscale
structural
characterization
hybrid
cationic
peptide
containing
hydrogels
(HGs).
these
matrices,
well-known
low-molecular-weight
hydrogelator,
Fmoc-diphenylalanine
(Fmoc-FF,
Fmoc
=
fluorenyl
methoxycarbonyl),
was
mixed
with
library
amphiphilic
peptides
(CAPs)
differing
their
alkyl
chain
(from
C8
C18)
1/1
mol/mol
ratio.
highlighted
that
HGs,
aggregation
guided
by
Fmoc-FF,
whereas
are
only
partially
immobilized
into
hydrogelated
matrix.
Moreover,
morphology,
stiffness,
topography,
toxicity
significantly
affected
length
chain.
capability
negative
evaluated
using
5-carboxyfluorescein
(5-FAM)
dye
as
model.
Drug Delivery,
Journal Year:
2025,
Volume and Issue:
32(1)
Published: Jan. 9, 2025
Biopolymers,
such
as
collagens,
elastin,
silk
fibroin,
spider
silk,
fibrin,
keratin,
and
resilin
have
gained
significant
interest
for
their
potential
biomedical
applications
due
to
biocompatibility,
biodegradability,
mechanical
properties.
This
review
focuses
on
the
design
integration
of
biomimetic
peptides
into
these
biopolymer
platforms
control
release
bioactive
molecules,
thereby
enhancing
functionality
drug
delivery,
tissue
engineering,
regenerative
medicine.
Elastin-like
polypeptides
(ELPs)
fibroin
repeats,
example,
demonstrate
how
engineered
can
mimic
natural
protein
domains
modulate
material
properties
profiles.
Recombinant
proteins,
fibrin-binding
peptides,
collagen-mimetic
keratin-derived
structures
similarly
illustrate
ability
engineer
precise
interactions
controlled
systems.
Additionally,
use
resilin-like
showcases
creating
highly
elastic
resilient
biomaterials.
highlights
current
achievements
future
perspectives
in
field,
emphasizing
transform
biopolymer-based
applications.
Small Structures,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
The
increasing
demand
of
advanced
biomedical
materials
for
bone
repair
and
regeneration
has
spurred
significant
research
in
recent
years.
While
traditional
hydrogels
offer
promising
biocompatibility
easy
fabrication,
their
application
reconstruction
is
often
impeded
by
inadequate
structural
integrity
biological
functions.
Graphene
oxide
(GO)
emerged
as
a
transformative
additive,
renowned
its
exceptional
mechanical
chemical
properties,
well
ability
to
enhance
the
hydrogels.
In
this
study,
incorporation
GO
into
chitosan
(CS)
investigated,
achieving
bioinspired
with
enhanced
strength
stability,
which
are
crucial
supporting
regeneration.
Additionally,
self‐assembled
synthetic
peptide
nanofibers
(PNFs)
employed
facilitate
biomimetic
mineralization
hydrogels,
critical
process
effective
remodeling.
This
innovative
composite
hydrogel
not
only
achieves
but
also
exhibits
osteogenic,
pro‐angiogenic,
antioxidant
properties
essential
repair.
novel
method
takes
advantage
distinctive
GO,
PNFs,
biomass
providing
robust
material
solution
potential
significantly
advance
field
tissue
engineering.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Cancer
is
becoming
a
global
threat,
as
the
cancerous
cells
manipulate
themselves
frequently,
resulting
in
mutants
and
more
abnormalities.
Early-stage
real-time
detection
of
cancer
biomarkers
can
provide
insight
into
designing
cost-effective
diagnostic
therapeutic
modalities.
Nanoparticle
quantum
dot
(QD)-based
approaches
have
been
recognized
clinically
relevant
methods
to
detect
disease
at
molecular
level.
Over
decades,
an
emergent
noninvasive
approach,
photothermal
therapy
has
evolved
eradicate
cancer.
Moreover,
various
structures,
viz.,
nanoparticles,
clusters,
dots,
etc.,
tested
bioimaging
agents
identify
tumor
selectively.
Among
them,
QDs
versatile
probes.
They
attracted
enormous
attention
for
imaging
applications
due
their
unique
colloidal
stability,
optical
physicochemical
properties,
biocompatibility,
easy
surface
conjugation,
scalable
production,
etc.
However,
few
critical
concerns
QDs,
precise
engineering
sensing,
selective
interaction
with
biological
system,
associated
toxicity,
restrict
potential
intervention
curing
are
yet
be
explored.
According
U.S.
Food
Drug
Administration
(FDA),
there
no
specific
regulation
approval
nanomedicines.
Therefore,
these
nanomedicines
undergo
traditional
drug,
biological,
device
process.
market
survey
increasing,
prospects
translational
nanomedicine
very
promising.
From
this
perspective,
we
discuss
importance
imaging,
usage
pertinent
cancer,
especially
its
early
stages.
also
rapidly
growing
view
QDs.
The
long-term
safety
studies
cellular
could
enhance
visibility
bring
photothermally
active
clinical
stage
concurrently
FDA
approval.
Small Structures,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
The
clinical
treatment
of
central
nervous
system
(CNS)
injuries
presents
significant
challenges
due
to
the
inflammatory
microenvironment
(IME)
induced
by
CNS
injury,
which
inhibits
spontaneous
neuronal
regeneration.
Biomimetic
biomaterial‐based
IMEs
for
repair,
facilitate
reconstruction
neural
regeneration
circuits,
show
promise.
In
this
study,
development
novel
bioactive
peptide
nanofibers
(PNFs)/chitosan
(CS)/VD11
(VDELWPPWLPC)
hydrogels
(named
as
PCV)
is
reported,
created
reinforcing
composite
PNFs/CS
with
a
frog‐derived
neuroregenerative
(VD11).
exhibit
3D
porous
structure,
high
thermosensitivity,
good
injectability,
and
enhanced
neurotrophic
properties,
making
them
promising
candidates
repair.
in
vitro
tests
indicate
that
PCV
can
promote
proliferation,
migration,
differentiation
stem
cells
into
neurons,
well
guide
axonal
growth.
Additionally,
they
help
mitigate
responses
reducing
macrophage
activation
astrocyte
while
promoting
neovascularization.
vivo
animal
experimentsdemonstrate
enhance
blood
supply
damaged
area
migration
colonization
endogenous
support
Furthermore,
reduce
immune
limit
excessive
significantly
improving
motor
function
recovery
rats
spinal
cord
injuries.
these
findings,
it
suggested
provide
strategy
treating
regulating
IME.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
This
article
explores
the
hierarchical
self-assembly
of
short
peptides,
which
refers
to
structured
spatial
arrangements
these
molecules
over
long
distances.
phenomenon
is
commonly
found
in
nature
and
has
important
implications
for
biological
structure
function.
Short
peptides
are
preferred
because
they
have
ability
spontaneously
create
various
nanostructures.
process,
known
as
bottom-up
assembly,
allows
addition
functional
groups
at
carboxyl
or
amine
ends
peptides.
These
enable
specific
functions
that
extremely
valuable
fields
biotechnology
biomedicine.
text
discusses
basic
processes
involved
such
characteristics
amino
acid
side
chains,
categorization
according
their
chemical
structure,
influence
intermolecular
forces,
dynamic
process.
In
addition,
paper
uses
disciplines
biomedicine
optoelectronics,
including
stimulus-responsive
hydrogels,
tissue
engineering,
drug
delivery.
The
also
suggests
rational
design
principles
controlling
creating
new
commercial
applications,
particularly
with
offers
insights
into
future
discipline.
The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Abstract
Biomolecule‐engineered
metal‐organic
frameworks
(Bio‐MOFs)
are
designed
by
incorporating
biomolecules
into
or
onto
MOFs
through
covalent
and
non‐covalent
interactions.
These
composite
exhibit
unique
catalytic
biological
activities,
making
them
highly
suitable
for
various
biocatalytic
applications.
In
this
review,
we
highlight
recent
advances
in
the
material
design,
bioengineering
methods,
structural
functional
regulation
techniques,
applications
of
Bio‐MOFs.
From
a
materials
perspective,
explore
their
structures
multifunctional
properties,
including
high
surface
area,
tunable
pore
sizes,
excellent
biocompatibility.
We
also
discuss
techniques
such
as
biomineralization
post‐synthetic
modification
that
employed
synthesis.
Furthermore,
examine
regulations
Bio‐MOFs,
which
enhance
activity
stability
interactions
with
enzymes,
peptides,
other
biomolecules.
Finally,
analyze
diverse
reactions,
biosensors/sensors,
drug
delivery,
therapy,
organic
wastewater
purification,
emerging
bio‐energy
science.
This
review
underscores
pivotal
role
enhancing
functions
aims
to
inspire
design
synthesis
novel
Bio‐MOFs
future
bio‐related
