Advances in Photothermal and Photodynamic Nanotheranostics for Precision Cancer Treatment DOI Creative Commons
Hossein Omidian, Sumana Dey Chowdhury

Journal of Nanotheranostics, Journal Year: 2024, Volume and Issue: 5(4), P. 228 - 252

Published: Dec. 13, 2024

Nanotheranostics, combining photothermal therapy (PTT) and photodynamic (PDT), can transform precision cancer treatment by integrating diagnosis into a single platform. This review highlights recent advances in nanomaterials, drug delivery systems, stimuli-responsive mechanisms for effective PTT PDT. Multifunctional nanoparticles enable targeted delivery, multimodal imaging, controlled release, overcoming the challenges posed tumor microenvironments. Emerging approaches such as hybrid therapies immune activation further enhance therapeutic efficacy. paper discusses limitations of nanotheranostics, including synthesis complexity limited tissue penetration, explores future directions toward biocompatible, scalable, clinically translatable solutions.

Language: Английский

Cu-Mn Nanocomposite for Enhanced Tumor Cuproptosis achieved by Remodeling the Tumor Microenvironment and Activating the Antitumor Immunogenic Responses DOI
Mengke Fan, Pan‐Chyr Yang,

Linlin Huo

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Epigenetic nanoplatform for synergistic immune activation and immunogenicity restoration enhancing cancer radio-immunotherapy DOI

Zhenhu He,

Xiaopei Peng,

Jiong Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161177 - 161177

Published: March 1, 2025

Language: Английский

Citations

0
Carboxylesterase-Triggered Theranostic Agent: Advancing Near-Infrared Imaging and Therapeutic Efficacy in Hepatocellular Carcinoma DOI
Fan Zheng,

Heying Yao,

Duoyang Fan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Hepatocellular carcinoma (HCC) poses a global challenge due to the lack of accurate early stage detection methods. Carboxylesterase (CE), key HCC biomarker, presents an ideal target for diagnosis. Herein, we developed novel CE-sensitive fluorescent probe (HFP-CE) that offered powerful near-infrared fluorescence signals and potent synergistic photodynamic/chemodynamic therapeutic effect against HCC. This was synthesized by linking ferrocenecarboxylic acid (a Fenton reagent) HFP-OH photosensitizer) through self-eliminating spacer. activation enabled ratiometric imaging CE, allowing specific differentiation cells from others, exceeding capabilities commercial kits. Moreover, HFP-CE could generate 1O2 •OH upon CE in vitro, triggering both apoptosis ferroptosis cancer cells. Remarkably, real-time tumor visualization effective growth inhibition vivo. study showcased promise as versatile tool advancing precision medicine

Language: Английский

Citations

0
The redox homeostasis-reshapable hyaluronic acid-drug conjugate augments chemo-photodynamic therapy DOI
Wenxia Zhang, Hui Qiao,

Jicheng Cui

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143465 - 143465

Published: April 23, 2025

Language: Английский

Citations

0
Multifunctional Hyaluronic Acid Ligand-Assisted Construction of CD44-and Mitochondria-Targeted Self-Assembled Upconversion Nanoparticles for Enhanced Photodynamic Therapy DOI

Ze Hao Liu,

Xin Wang Mo,

Wei Jiang

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Upconversion nanoparticles (UCNPs) have been used as a potential nanocarrier for photosensitizers (PSs), which demonstrated great deal of promise in achieving an effective photodynamic therapy (PDT) deep-seated tumors.

Language: Английский

Citations

3
Synergistic Photodynamic and Chemodynamic Therapy for Tumor Treatment Using a Glutathione-Activated Photosensitizer with Near-Infrared (NIR) Imaging DOI
Fan Zheng, Duoyang Fan,

Heying Yao

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: unknown, P. 4673 - 4681

Published: Sept. 10, 2024

Language: Английский

Citations

1
A multifunctional hyaluronic acid-engineered mesoporous nanoreactor with H2O2/O2 self-sufficiency for pH-triggered endo-lysosomal escape and synergetic cancer therapy DOI
Fei Lu, Moon‐Sun Jang, Wei Jiang

et al.

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 169, P. 214161 - 214161

Published: Dec. 23, 2024

Language: Английский

Citations

1
Pyroptosis-Mediated Cancer Chemodynamic Therapy Driven by Multicascade Responsive Nanocatalyst DOI
Bo Hu,

Shiwen Gao,

Shaoqing Luo

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(9), P. 4333 - 4342

Published: Aug. 21, 2024

The off-target side effects and low catalytic efficiency substantially hindered the biomedical application of chemodynamic therapy (CDT). Here, we report a novel pH/GSH cascade activated core–shell nanocatalyst (MDC) to enhance cancer targeting for synergistic CDT. CaCO3 shell protects internal MnSiO3 from degradation by GSH during blood transport. In an acidic tumor microenvironment, rapid biodegradation induces CO2 production, pH increase, Ca2+ overload. Subsequently, exposed core serves as drug delivery platform with responsive Mn2+ dihydroartemisinin (DHA) release function. generated optimizes conditions, DHA acting substrate catalysis, both which promote Mn2+-mediated ROS generation. synergy overload, they collectively accelerate storm ROS, activating Caspase-1/gasdermin D mediated pyroptosis achieved remarkable inhibition. Such multicascade nanoplatform is highly instructive further metal nanocatalysts therapies.

Language: Английский

Citations

0
Advances in Photothermal and Photodynamic Nanotheranostics for Precision Cancer Treatment DOI Creative Commons
Hossein Omidian, Sumana Dey Chowdhury

Journal of Nanotheranostics, Journal Year: 2024, Volume and Issue: 5(4), P. 228 - 252

Published: Dec. 13, 2024

Nanotheranostics, combining photothermal therapy (PTT) and photodynamic (PDT), can transform precision cancer treatment by integrating diagnosis into a single platform. This review highlights recent advances in nanomaterials, drug delivery systems, stimuli-responsive mechanisms for effective PTT PDT. Multifunctional nanoparticles enable targeted delivery, multimodal imaging, controlled release, overcoming the challenges posed tumor microenvironments. Emerging approaches such as hybrid therapies immune activation further enhance therapeutic efficacy. paper discusses limitations of nanotheranostics, including synthesis complexity limited tissue penetration, explores future directions toward biocompatible, scalable, clinically translatable solutions.

Language: Английский

Citations

0