Published: Jan. 1, 2024
Language: Английский
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 677, P. 816 - 826
Published: Aug. 16, 2024
Language: Английский
Citations
19
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 206 - 206
Published: March 15, 2025
Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 791 - 791
Published: June 16, 2024
This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs medical treatment monitoring. Innovations hydrogel-integrated MN arrays facilitate controlled release, thereby expanding options for chronic diseases conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, manufacturing processes, well achievements advanced manufacturing, biocompatibility, versatile applications. Nonetheless, limitations physiological responsiveness long-term stability remain, necessitating further research material innovation integration with digital technologies. Future directions focus on biomedical applications, advancements, regulatory considerations widespread clinical adoption.
Language: Английский
Citations
4
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(7), P. 1053 - 1068
Published: July 2, 2024
Introduction Microneedles (MNs) are miniaturized, painless, and minimally invasive platforms that have attracted significant attention over recent decades across multiple fields, such as drug delivery, disease monitoring, diagnosis, cosmetics. Several manufacturing methods been employed to create MNs; however, these approaches come with drawbacks related complicated, costly, time-consuming fabrication processes. In this context, employing additive (AM) technology for MN allows the quick production of intricate prototypes exceptional precision, providing flexibility customize MNs according desired shape dimensions. Furthermore, AM demonstrates promise in sophisticated transdermal delivery systems medical devices through integration various technologies.
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995
Published: Nov. 1, 2024
Language: Английский
Citations
4
Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)
Published: Dec. 1, 2024
ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.
Language: Английский
Citations
4
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 684, P. 201 - 212
Published: Jan. 7, 2025
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106748 - 106748
Published: Feb. 22, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161043 - 161043
Published: Feb. 1, 2025
Language: Английский
Citations
0
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103470 - 103470
Published: March 7, 2025
Language: Английский
Citations
0