Synthetic Metals, Journal Year: 2024, Volume and Issue: 309, P. 117775 - 117775
Published: Nov. 4, 2024
Language: Английский
Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Composite nanozymes are composed of enzymes with similar or different catalytic capabilities and have higher activity than a single enzyme. In recent years, composite emerged as novel nanomaterial platforms for multiple applications in various research fields, where they used to produce oxygen, consume glutathione, toxic reactive oxygen species (ROS) cancer therapy. The therapeutic approach using is known chemo-dynamic therapy (CDT). Some also show special photothermal conversion effects, enabling them be combined pioneering treatments, such photodynamic (PDT), (PTT) sonodynamic (SDT), enhance the anti-cancer effects. this study, classification performances reviewed, along their advantages synthesis methods. Furthermore, treatment cancers emphasized, prospective challenges future discussed.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 709 - 709
Published: Jan. 15, 2025
Nanozymes, a kind of nanoparticles with enzyme-mimicking activities, have attracted considerable attention due to their robust catalytic properties, ease preparation, and resistance harsh conditions. By combining nanozymes surface-enhanced Raman spectroscopy (SERS) technology, highly sensitive selective sensors been developed. These are capable detecting wide range analytes, such as foodborne toxins, environmental pollutants, biomedical markers. This review provides an overview recent advancements in the synthesis surface modification nanozymes, highlighting ability mimic multiple enzymes enhance performance. In addition, we explore development applications nanozyme-based SERS food contaminants, The concludes perspectives challenges facing field, involving need for deeper understanding nanozyme principles mechanisms, standardized systems characterization, engineering tailored properties specific applications. Finally, discuss potential integrating various techniques create multi-modal detection platforms, paving way next generation analytical tools fields safety, monitoring, diagnostics.
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5460 - 5467
Published: Feb. 8, 2025
Photothermal therapy (PTT) presents unique advantages, including high temporal and spatial controllability relatively few toxic side effects. Active targeting modifications of photothermal agents can deliver nanoprobes to tumors more efficiently, reducing effects while improving efficacy. In this work, the polyphenols, gallic acid, folic acid (FA), hyaluronic (HA), Fe(III) were selected prepare a self-photothermal nanoplatform Ga/Fe/HA/FA based on polyphenol-metal self-assembly. The self-assembly process synchronously integrated molecules, layer by in network, thus realizing "layer-by-layer targeting" effect. Compared with traditional modification, multitargeting modification strategy effectively avoided complicated experimental steps modification. Meanwhile, it mitigated off-target risk during blood circulation improved tumor-targeting efficiency, ultimately augmenting effectiveness therapy.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161091 - 161091
Published: Feb. 1, 2025
Language: Английский
Citations
0
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Recently, green gas therapy based on nitric oxide (NO) has gained considerable attention in cancer treatment. The supplementation of exogenous NO and its controlled release represent promising strategies for adjuvant tumor therapy. In this study, we developed a novel ultrasound (US)-triggered generation nanoplatform that integrates therapy, sonodynamic photothermal (PTT) into collaborative therapeutic modality. An environmentally friendly biomacromolecule, polydopamine, was employed to coload chlorin e6 (Ce6) donor (BNN6), resulting the nanocomposite PDA-Ce6/BNN6 (PCB). A single US stimulus simultaneously activated Ce6 produce reactive oxygen species (ROS) promoted BNN6 NO. dual effects ultrasonic mechanical action physiological modulation by substantially improved local vascular function enhanced cell permeability, thereby increasing targeted accumulation PCB within tumors. Reactive nitrogen (RNS) derived from ROS further exacerbated oxidative damage sensitivity cells hyperthermia. Both vitro vivo experiments demonstrated stimulation NO/ROS/RNS combined with PTT effectively inhibited growth proliferation. findings suggest extracorporeal can significantly amplify efficacy offer new insights developing other aimed at physically regulating deep
Language: Английский
Citations
0
Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 28, 2025
ABSTRACT Due to the heterogeneity of tumor, it is difficult achieve complete ablation tumor by single photothermal treatment. Moreover, their broader use constrained intrinsic high uptake in reticuloendothelial system (RES) organs, resulting slow elimination from body and potential toxicity. In this study, we report a single‐step synthetic approach fabricate versatile FeCP‐NPs, leveraging coordination bonds formed between bioactive polyphenolic compounds (curcumin), Fe III ions, polyvinyl pyrrolidone (PVP). The FeCP‐NPs possess following favorable characteristics: (1) components originate natural products, an endogenous element, FDA‐approved polymer, guaranteeing good biosafety. (2) exhibit excellent properties. (3) After treatment completed, dynamic disassembly strategy triggered deferoxamine mesylate (DFO) can induce dissociation nanoparticles rapid clearance vivo. (4) Curcumin released during be combined with therapy ablation. A comprehensive analysis safety, biodistribution, patterns conducted vitro or This work provides nanoparticle great clinical translational new solution for inhibiting growth.
Language: Английский
Citations
0
Synthetic Metals, Journal Year: 2024, Volume and Issue: 309, P. 117775 - 117775
Published: Nov. 4, 2024
Language: Английский
Citations
0