ACS Applied Materials & Interfaces,
Journal Year:
2017,
Volume and Issue:
9(4), P. 3487 - 3496
Published: Jan. 9, 2017
In
recent
years,
in
situ
chemotherapy
mediated
by
biodegradable
polymer
platforms
has
attracted
increased
attention.
Herein,
an
advanced
drug
delivery
system,
combretastatin
A-4
(CA4)
and
docetaxel
(DTX)-loaded
microsphere
embedded
injectable
thermosensitive
polypeptide
hydrogel
(i.e.,
hydrogel-microsphere
(Gel-MP)
construct),
was
reported
for
sequential
release
of
drugs
with
different
mechanisms
to
treat
osteosarcoma
synergistically.
The
Gel-MP
construct
showed
biodegradability
excellent
biocompatibility.
CA4
preferentially
released
from
faster
degradation
disturb
the
vascular
structure
tumor
reduce
exchange
nutrients
between
surrounding
tissues,
which
created
interstitial
space
tissue
DTX
penetration
inhibit
cell
proliferation.
vivo
treatment
Gel/CA4-MP/DTX
efficiently
suppressed
growth
mouse
K7
compared
other
formulations.
More
importantly,
systematical
study
histopathology
immunohistochemistry,
can
significantly
upregulate
antiproliferation
effect
toxicity
drugs.
Therefore,
this
locally
system
a
bright
prospect
clinical
application
synergistic
chemotherapy.
ACS Applied Materials & Interfaces,
Journal Year:
2018,
Volume and Issue:
10(24), P. 20897 - 20909
Published: June 4, 2018
Integrating
multifunctionality
such
as
adhesiveness,
stretchability,
and
self-healing
ability
on
a
single
hydrogel
has
been
challenge
is
highly
desired
development
for
various
applications
including
electronic
skin,
wound
dressings,
wearable
devices.
In
this
study,
novel
was
synthesized
by
incorporating
polydopamine-coated
talc
(PDA-talc)
nanoflakes
into
polyacrylamide
(PAM)
inspired
the
natural
mussel
adhesive
mechanism.
Dopamine
molecules
were
intercalated
oxidized,
which
enhanced
dispersion
of
preserved
catechol
groups
in
hydrogel.
The
resulting
dopamine-talc-PAM
(DTPAM)
showed
remarkable
with
over
1000%
extension
recovery
rate
99%.
It
also
displayed
strong
adhesiveness
to
substrates,
human
adhesion
strength
surpassed
that
commercial
double-sided
tape
glue
sticks,
even
dehydrated
time.
Moreover,
DTPAM
could
rapidly
self-heal
regain
its
mechanical
properties
without
needing
any
external
stimuli.
excellent
biocompatibility
improved
cell
affinity
fibroblasts
compared
PAM
When
used
strain
sensor,
high
sensitivity,
gauge
factor
0.693
at
strain,
capable
monitoring
motions
bending
finger,
knee,
or
elbow
taking
deep
breath.
Therefore,
displays
favorable
attributes
suitable
use
human-friendly
biological
Theranostics,
Journal Year:
2020,
Volume and Issue:
10(3), P. 1355 - 1372
Published: Jan. 1, 2020
The
current
achievements
in
treating
glioblastoma
(GBM)
patients
are
not
sufficient
because
many
challenges
exist,
such
as
tumor
heterogeneity,
the
blood
brain
barrier,
glioma
stem
cells,
drug
efflux
pumps
and
DNA
damage
repair
mechanisms.Drug
combination
therapies
have
shown
increasing
benefits
against
those
challenges.With
help
of
nanocarriers,
enhancement
efficacy
safety
could
be
gained
using
synergistic
combinations
different
therapeutic
agents.In
this
review,
we
will
discuss
major
issues
for
GBM
treatment,
rationales
with
or
without
nanocarriers
principle
enhanced
permeability
retention
effect
involved
nanomedicine-based
targeting
promising
nanodiagnostics
-therapeutics.We
also
summarize
recent
progress
clinical
perspectives
nanocarrier-based
therapies.The
goal
article
was
to
provide
better
understanding
key
considerations
develop
new
nanomedicine
nanotheranostics
options
fight
GBM.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(31)
Published: May 13, 2018
Abstract
In
spite
of
remarkable
improvements
in
cancer
treatments
and
survivorship,
still
remains
as
one
the
major
causes
death
worldwide.
Although
current
standards
care
provide
encouraging
results,
they
cause
severe
systemic
toxicity
also
fail
preventing
recurrence
disease.
order
to
address
these
issues,
biomaterial‐based
implantable
drug
delivery
systems
(DDSs)
have
emerged
promising
therapeutic
platforms,
which
allow
local
administration
drugs
directly
tumor
site.
Owing
unique
properties
biopolymers,
been
used
a
variety
ways
institute
biodegradable
DDSs
that
exert
precise
spatiotemporal
control
over
release
drug.
Here,
most
recent
advances
biopolymer‐based
for
suppressing
growth
are
reviewed.
Novel
emerging
biopolymers
well
cutting‐edge
polymeric
microdevices
deployed
antitumor
discussed.
Finally,
review
new
modality
within
field,
is
based
on
biopolymeric
DDSs,
given.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(51)
Published: Oct. 16, 2018
Glioblastoma
multiforme
(GBM)
is
a
fatal
central
nervous
system
tumor
without
effective
treatment.
Chemotherapeutic
agents
are
mainstays
in
the
treatment
of
glioblastoma.
However,
effectiveness
these
seriously
hindered
by
poor
blood-brain-barrier
(BBB)
penetrance
and
targeting,
together
with
short
biological
half-life.
Improved
chemotherapy
thus
urgently
needed
for
GBM.
Multifunctional
nanoparticle
delivery
systems
offer
much
promise
overcoming
current
limitations.
Accordingly,
multifunctional
biomimetic
nanomedicine
developed
functionalizing
surface
red
blood
cell
membranes
(RBCms)
angiopep-2
loading
pH-sensitive
nanoparticles
(polymer,
doxorubicin
(Dox),
lexiscan
(Lex))
using
functionalized
membrane
to
generate
novel
nanomedicine,
Ang-RBCm@NM-(Dox/Lex).
The
studies
toward
orthotopic
U87MG
human
glioblastoma
tumor-bearing
nude
mice
show
that
Ang-RBCm@NM-(Dox/Lex)
has
improved
circulation
time,
superb
BBB
penetration,
superior
accumulation
retention.
Moreover,
suppression
growth
significantly
medium
survival
time
also
observed
after
results
this
nanoplatform
can
serve
as
flexible
powerful
GBM
which
be
readily
adapted
other
(CNS)
disorders.
Advanced Healthcare Materials,
Journal Year:
2018,
Volume and Issue:
7(9)
Published: Feb. 1, 2018
In
spite
of
significant
advancement
in
hydrogel
technology,
low
mechanical
strength
and
lack
electrical
conductivity
have
limited
their
next-level
biomedical
applications
for
skeletal
muscles,
cardiac
neural
cells.
Host-guest
chemistry
based
hybrid
nanocomposites
systems
gained
attention
as
they
completely
overcome
these
pitfalls
generate
bioscaffolds
with
tunable
characteristics.
recent
years,
carbon
nanotube
(CNT)-based
hydrogels
emerged
innovative
candidates
diverse
regenerative
medicines,
tissue
engineering,
drug
delivery
devices,
implantable
biosensing,
biorobotics.
This
article
is
an
attempt
to
recapitulate
the
synthesis
characterization
provide
deep
insights
toward
functioning
success
devices.
The
improved
comparative
performance
biocompatibility
CNT-hydrogels
hybrids
developed
targeted
are
addressed
here.
Recent
updates
limitations
CNT
review.
will
a
holistic
approach
understanding
CNT-based
nanotheranostics.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(25)
Published: May 11, 2020
Abstract
For
breast
cancer
patients
who
have
undergone
breast‐conserving
surgery,
effective
treatments
to
prevent
local
recurrences
and
metastases
is
very
essential.
Here,
a
injectable
therapeutic
platform
based
on
thermosensitive
PLEL
hydrogel
with
near‐infrared
(NIR)‐stimulated
drug
release
developed
achieve
synergistic
photothermal
immunotherapy
for
prevention
of
postoperative
relapse.
Self‐assembled
multifunctional
nanoparticles
(RIC
NPs)
are
composed
three
components
including
indocyanine
green,
agent;
resiquimod
(R848),
TLR‐7/8
agonist;
CPG
ODNs,
TLR‐9
agonist.
RIC
NPs
physically
incorporated
into
the
hydrogel.
The
encapsulated
NPs@PLEL)
then
locally
injected
tumor
resection
cavity
therapy
ablate
residue
tissues
produce
tumor‐associated
antigens.
At
same
time,
NIR
also
triggers
immune
ODNs
R848
from
thermoresponsive
hydrogels
PLEL.
released
components,
together
antigens,
work
as
an
in
situ
vaccine
postsurgical
by
inducing
sustained
antitumor
effect.
Overall,
this
suggests
that
delivery
system
has
great
potential
promising
tool
management
metastases.
