Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12567 - 12603

Published: Aug. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Language: Английский

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Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 11, 2021

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC only cured by surgical resection in its early stage, but there remains relatively high possibility of recurrence. The development closely associated with the tumor microenvironment. Tumor-associated macrophages (TAMs) are one most abundant immune cell populations pancreatic stroma. TAMs inclined to M2 deviation microenvironment, which promotes and supports behaviors, including tumorigenesis, escape, metastasis, chemotherapeutic resistance. Herein, we comprehensively reviewed latest researches on origin, polarization, functions, reprogramming PDAC.

Language: Английский

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Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

Bone Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Feb. 27, 2023

Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding efforts of researchers, its five-year rate has only shown limited improvement, suggesting that existing therapeutic strategies are insufficient to meet clinical needs. Notably, immunotherapy certain advantages over traditional tumor treatments inhibiting metastasis. Therefore, managing immune microenvironment osteosarcoma can provide novel and valuable insight into multifaceted mechanisms underlying heterogeneity progression disease. Additionally, given advances nanomedicine, there exist many advanced nanoplatforms for enhanced satisfactory physiochemical characteristics. Here, we review classification, characteristics, functions key components osteosarcoma. This also emphasizes application, progress, prospects discusses several nanomedicine-based options enhance efficiency treatment. Furthermore, examine disadvantages standard present future perspectives immunotherapy.

Language: Английский

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Concepts and Approaches to Reduce or Avoid Protein Corona Formation on Nanoparticles: Challenges and Opportunities

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

This review describes the formation of a protein corona (or its absence) on different classes nanoparticles, basic principles, and consequences for nanomedicine. For this purpose, it general concepts to control (guide/minimize) interaction between artificial nanoparticles plasma proteins reduce formation. Thereafter, methods qualitative or quantitative determination are presented, as well properties nanoparticle surfaces, which relevant prevention formation). Thereby especially role grafting density hydrophilic polymers surface is discussed prevent corona. In context also potential detergents (surfactants) temporary modification grafting-to grafting-from approaches permanent discussed. The concludes by highlighting several promising avenues. includes (i) use without active targeting, (ii) synthetic address immune system, (iii) recollection with defined after in vivo application sample blood proteome (iv) further

Language: Английский

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Bioinspired and Biomimetic Nanotherapies for the Treatment of Infectious Diseases

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: July 5, 2019

There are still great challenges for the effective treatment of infectious diseases, although considerable achievement has been made by using antiviral and antimicrobial agents varying from small-molecule drugs, peptides/proteins, to nucleic acids. The nanomedicine approach is emerging as a new strategy capable overcoming disadvantages molecular therapeutics amplifying their anti-infective activities, localized delivery infection sites, reducing off-target effects, and/or attenuating resistance development. Nanotechnology, in combination with bioinspired biomimetic approaches, affords additional functions nanoparticles derived synthetic materials. Herein, we aim provide state-of-the-art review on recent progress bioengineered nanotherapies disease. Different nanoparticles, viruses, bacteria, mammalian cells, first described, respect construction biophysicochemical properties. Then, applications diverse therapy introduced, either intrinsic activity or loading site-specifically delivering various drugs. Bioinspired nanovaccines prevention diseases also highlighted. At end, major translation issues future directions this field discussed.

Language: Английский

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Hybrid Membrane-Coated Biomimetic Nanoparticles (HM@BNPs): A Multifunctional Nanomaterial for Biomedical Applications

Biomacromolecules, Journal Year: 2021, Volume and Issue: 22(8), P. 3149 - 3167

Published: July 6, 2021

The application of nanoparticles in the diagnosis and treatment diseases has undergone different developmental stages, but phagocytosis nonspecific distribution have been main factors restricting transformation nanobased drugs into clinical practice. In past decade, design membrane-coated gained increasing attention. It is hoped that combination cell membrane's natural biological properties functional integration synthetic nanoparticle systems can compensate for shortage traditional nanoparticles. membrane coating gives unique functions such as immune evasion targeting capability. However, when encapsulation monotypic membranes does not meet diverse demands biomedicine, may offer more possibilities. this review, composition, preparation, advantages biomimetic coated with hybrid are summarized, applications (HM@BNPs) drug delivery, phototherapy, liquid biopsy, tumor vaccines, therapy, detoxification reviewed. Finally, current challenges opportunities regard to HM@BNPs discussed.

Language: Английский

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Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4426 - 4443

Published: Feb. 1, 2022

The generation of specific humoral and cellular immune responses plays a pivotal role in the development effective vaccines against tumors. Especially presence antigen-specific, cytotoxic T cells influences outcome therapeutic cancer vaccinations. Different strategies, ranging from delivering antigen-encoding mRNAs to peptides or full antigens, are accessible but often suffer insufficient immunogenicity require immune-boosting adjuvants as well carrier platforms ensure stability adequate retention. Here, we introduce pH-responsive nanogel platform two-component antitumor vaccine that is safe for intravenous application elicits robust vitro vivo. underlying chemical design allows straightforward covalent attachment model antigen (ovalbumin) an adjuvant (imidazoquinoline-type TLR7/8 agonist) onto same nanocarrier system. In addition eliciting antigen-specific B cell outperform mixtures individual components, our nanovaccine leads prophylactic studies growth reduction different tumors expressing ovalbumin intracellularly on their surface. Regarding versatile opportunities functionalization, nanogels promising highly customized potent nanovaccines.

Language: Английский

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Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 9826 - 9849

Published: May 19, 2023

The development of nanovaccines that employ polymeric delivery carriers has garnered substantial interest in therapeutic treatment cancer and a variety infectious diseases due to their superior biocompatibility, lower toxicity reduced immunogenicity. Particularly, stimuli-responsive nanocarriers show great promise for delivering antigens adjuvants targeted immune cells, preventing antigen degradation clearance, increasing the uptake specific antigen-presenting thereby sustaining adaptive responses improving immunotherapy certain diseases. In this review, most recent advances utilization stimulus-responsive polymer-based immunotherapeutic applications are presented. These sophisticated with diverse functions, aimed at administration disease prevention immunotherapy, further classified into several active domains, including pH, temperature, redox, light ultrasound-sensitive intelligent nanodelivery systems. Finally, potential strategies future design multifunctional next-generation by integrating materials science biological interface proposed.

Language: Английский

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Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 773 - 800

Published: Dec. 14, 2023

Language: Английский

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Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(43), P. 15390 - 15395

Published: Aug. 9, 2019

Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes small-molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage inherent serum-protein-binding property lipid motifs their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid-polymer conjugates that suppress inflammation but provoke potent lymph-node activation. This work provides a rational basis amphiphiles optimized targeting.

Language: Английский

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