Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
14, P. 100223 - 100223
Published: Feb. 21, 2022
Inflammatory
arthritis
is
a
major
cause
of
disability
in
the
elderly.
This
condition
causes
joint
pain,
loss
function,
and
deterioration
quality
life,
mainly
due
to
osteoarthritis
(OA)
rheumatoid
(RA).
Currently,
available
treatment
options
for
inflammatory
include
anti-inflammatory
medications
administered
via
oral,
topical,
or
intra-articular
routes,
surgery,
physical
rehabilitation.
Novel
alternative
approaches
managing
arthritis,
so
far,
remain
grand
challenge
owing
catastrophic
financial
burden
insignificant
therapeutic
benefit.
In
view
non-targeted
systemic
cytotoxicity
limited
bioavailability
drug
therapies,
concern
establish
stimuli-responsive
delivery
systems
using
nanomaterials
with
on-off
switching
potential
biomedical
applications.
review
summarizes
advanced
applications
triggerable
dependent
on
various
internal
stimuli
(including
reduction-oxidation
(redox),
pH,
enzymes)
external
temperature,
ultrasound
(US),
magnetic,
photo,
voltage,
mechanical
friction).
The
also
explores
progress
challenges
use
manage
based
pathological
changes,
including
cartilage
degeneration,
synovitis,
subchondral
bone
destruction.
Exposure
appropriate
induced
by
such
histopathological
alterations
can
trigger
release
medications,
imperative
joint-targeted
arthritis.
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
11(10), P. 3060 - 3091
Published: May 7, 2021
Acute
respiratory
distress
syndrome
(ARDS)
is
characterized
by
the
severe
inflammation
and
destruction
of
lung
air-blood
barrier,
leading
to
irreversible
substantial
function
damage.
Patients
with
coronavirus
disease
2019
(COVID-19)
have
been
encountered
a
high
risk
ARDS,
underscoring
urgency
for
exploiting
effective
therapy.
However,
proper
medications
ARDS
are
still
lacking
due
poor
pharmacokinetics,
non-specific
side
effects,
inability
surmount
pulmonary
inadequate
management
heterogeneity.
The
increased
permeability
in
pathological
environment
may
contribute
nanoparticle-mediated
passive
targeting
delivery.
Nanomedicine
has
demonstrated
unique
advantages
solving
dilemma
drug
therapy,
which
can
address
shortcomings
limitations
traditional
anti-inflammatory
or
antioxidant
treatment.
Through
passive,
active,
physicochemical
targeting,
nanocarriers
interact
epithelium/endothelium
inflammatory
cells
reverse
abnormal
changes
restore
homeostasis
environment,
thereby
showing
good
therapeutic
activity
reduced
toxicity.
This
article
reviews
latest
applications
nanomedicine
pre-clinical
highlights
strategies
targeted
treatment
inflammation,
presents
innovative
delivery
systems,
provides
inspiration
strengthening
effect
nanomedicine-based
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(10), P. 16076 - 16094
Published: Oct. 4, 2021
Stroke
is
a
primary
cause
of
death
and
disability
worldwide,
while
effective
safe
drugs
remain
to
be
developed
for
its
clinical
treatment.
Herein,
we
report
bioactive
nanoparticle-derived
multifunctional
nanotherapies
ischemic
stroke,
which
are
engineered
from
pharmacologically
active
oligosaccharide
material
(termed
as
TPCD)
prepared
by
covalently
conjugating
radical-scavenging
compound
(Tempol)
hydrogen-peroxide-eliminating
moiety
phenylboronic
acid
pinacol
ester
(PBAP)
on
β-cyclodextrin.
Of
note,
combined
functional
moieties
Tempol
PBAP
β-cyclodextrin
contribute
antioxidative
anti-inflammatory
activities
TPCD.
Cellularly,
TPCD
nanoparticles
(i.e.,
NPs)
reduced
oxygen-glucose
deprivation-induced
overproduction
oxidative
mediators,
increased
antioxidant
enzyme
expression,
suppressed
microglial-mediated
inflammation,
thereby
inhibiting
neuronal
apoptosis.
After
intravenous
(i.v.)
delivery,
NPs
could
efficiently
accumulate
at
the
cerebral
injury
site
mice
with
middle
artery
occlusion
(MCAO),
showing
considerable
distribution
in
cells
relevant
pathogenesis
stroke.
Therapeutically,
significantly
decreased
infarct
volume
accelerated
recovery
neurological
function
MCAO
mice.
Mechanistically,
efficacy
achieved
antioxidative,
anti-inflammatory,
antiapoptotic
effects.
Furthermore,
can
reactive
oxygen
species
labile
nanovehicle
load
triggerably
release
an
inflammation-resolving
peptide
Ac2-26,
giving
rise
nanotherapy
ATPCD
NP).
Compared
NP,
NP
demonstrated
notably
enhanced
vivo
efficacies,
largely
resulting
additional
activity.
Consequently,
NP-derived
nanomedicines
further
promising
targeted
therapies
stroke
other
inflammation-associated
cerebrovascular
diseases.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(16)
Published: Feb. 23, 2022
Functional
hydrogels
responsive
to
physiological
and
pathological
signals
have
extensive
biomedical
applications
owing
their
multiple
advanced
attributes.
Herein,
engineering
of
functional
is
reported
via
transformable
nanoparticles
in
response
the
physiologically
pathologically
acidic
microenvironment.
These
are
assembled
by
a
multivalent
hydrophobic,
pH-responsive
cyclodextrin
host
material
hydrophilic
guest
macromolecule.
Driven
protons,
host-guest
can
be
transformed
into
hydrogel,
resulting
from
proton-triggered
hydrolysis
material,
generation
compound,
simultaneously
enhanced
inclusion
interactions
between
molecules.
By
situ
forming
hydrogel
barrier,
orally
delivered
protect
mice
ethanol-
or
drug-induced
gastric
injury.
In
addition,
this
type
serve
as
nanovehicles
for
therapeutic
agents
achieve
triggerable
sustained
drug
delivery,
thereby
effectively
treating
typical
inflammatory
diseases,
including
periodontitis
arthritis
rats.
With
combined
advantages
hydrogels,
together
with
good
vivo
safety,
engineered
hold
great
promise
tissue
injury
protection
site-specific/local
delivery
molecular
cellular
agents.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(4), P. 778 - 778
Published: April 2, 2022
Liposomes
are
highly
advantageous
platforms
for
drug
delivery.
To
improve
the
colloidal
stability
and
avoid
rapid
uptake
by
mononuclear
phagocytic
system
of
conventional
liposomes
while
controlling
release
encapsulated
agents,
modification
with
well-designed
polymers
to
modulate
physiological,
particularly
interfacial
properties
carriers,
has
been
intensively
investigated.
Briefly,
incorporated
into
mainly
using
"grafting"
or
"coating",
defined
according
configuration
at
surface.
Polymer-modified
preserve
advantages
as
drug-delivery
carriers
possess
specific
functionality
from
polymers,
such
long
circulation,
precise
targeting,
stimulus-responsiveness,
thereby
resulting
in
improved
pharmacokinetics,
biodistribution,
toxicity,
therapeutic
efficacy.
In
this
review,
we
summarize
progress
polymer-modified
delivery,
focusing
on
change
physiological
factors
influencing
overall
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(10)
Published: Jan. 4, 2023
Abstract
Articular
cartilage
defects
bring
about
disability
and
worldwide
socioeconomic
loss,
therefore,
articular
repair
regeneration
is
recognized
as
a
global
issue.
However,
due
to
its
avascular
nearly
acellular
characteristic,
tissue
ability
limited
some
extent.
Despite
the
availability
of
various
treatment
methods,
including
palliative
drugs
surgical
regenerative
therapy,
still
face
major
challenges
lack
appropriate
methods
materials.
Smart
biomaterials
can
regulate
cell
behavior
provide
excellent
microenvironment,
thus
inducing
regeneration.
This
process
adjusted
by
controlling
drug/bioactive
factors
release
via
responding
exogenous/endogenous
stimuli,
tailoring
materials’
structure
function
similar
native
or
providing
physiochemical
physical
signaling
factors.
Herein,
smart
biomaterials,
recently
applied
in
regeneration,
are
elaborated
from
two
aspects:
drug
system
scaffolds.
Furthermore,
advanced
manufacturing
techniques
discussed
brief.
Finally,
perspectives
for
used
presented
clinical
translation
emphasized.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100597 - 100597
Published: Feb. 26, 2023
Osteoarthritis
(OA)
and
rheumatoid
arthritis
(RA)
are
chronic
progressive
inflammatory
joint
diseases
that
affect
a
large
population
worldwide.
Intra-articular
administration
of
various
therapeutics
is
applied
to
alleviate
pain,
prevent
further
progression,
promote
cartilage
regeneration
bone
remodeling
in
both
OA
RA.
However,
the
effectiveness
intra-articular
injection
with
traditional
drugs
uncertain
controversial
due
issues
such
as
rapid
drug
clearance
barrier
afforded
by
dense
structure
cartilage.
Nanoparticles
can
improve
efficacy
facilitating
controlled
release,
prolonged
retention
time,
enhanced
penetration
into
tissue.
This
review
systematically
summarizes
nanoparticle-based
therapies
for
RA
management.
Firstly,
we
explore
interaction
between
nanoparticles
joints,
including
articular
fluids
cells.
followed
comprehensive
analysis
current
designed
OA/RA,
divided
two
categories
based
on
therapeutic
mechanisms:
direct
nanoparticles-based
delivery
systems.
We
highlight
nanoparticle
design
tissue/cell
targeting
release
before
discussing
challenges
efficient
treatment
their
future
clinical
translation.
anticipate
rationally
local
will
be
more
effective,
convenient,
safer
than
approach.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(9), P. 4434 - 4483
Published: Jan. 1, 2024
Metal-organic
frameworks
have
become
promising
stimuli-responsive
agents
to
release
the
loaded
therapeutic
in
target
site
achieve
more
precise
drug
delivery
due
their
high
loading,
excellent
biocompatibility,
and
stimuli-responsiveness.
