Fluorous‐Tagged Peptide Nanoparticles Ameliorate Acute Lung Injury via Lysosomal Stabilization and Inflammation Inhibition in Pulmonary Macrophages DOI
Kun Wang, Guangyu Rong, Yixuan Gao

et al.

Small, Journal Year: 2022, Volume and Issue: 18(40)

Published: Sept. 7, 2022

Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical that currently has no effective therapeutic interventions. Pulmonary macrophages play principal role in the initiation and progression of overwhelming inflammation ALI/ARDS. Here, type fluorous‐tagged bioactive peptide nanoparticle termed CFF13F developed, which can be efficiently internalized by suppress excessive expression cytokines overproduction reactive oxygen species (ROS) triggered lipopolysaccharide (LPS). The cytoprotective effect may attributed to lysosomal‐stabilization property regulation antioxidative system. Moreover, intratracheal pretreatment with effectively reduce local systematic inflammation, ameliorate pulmonary damage an LPS‐induced ALI murine model. efficacy affected administration routes, injection found optimal choice for treatment, preferred biodistribution profiles. present study provides solid evidence potent immunomodulatory bioactivity nanoparticles vitro vivo, sheds light on development novel efficient nanodrugs

Language: Английский

Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury DOI Creative Commons

Zihe Zhai,

Wei Ouyang,

Yuejun Yao

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 14, P. 430 - 442

Published: Feb. 11, 2022

Acute lung injury (ALI) is associated with excessive inflammatory response, leading to acute respiratory distress syndrome (ARDS) without timely treatment. A fewer effective drugs are available currently treat the ALI/ARDS. Herein, a therapeutic nanoplatform reactive oxygen species (ROS)-responsiveness was developed for regulation of inflammation. Dexamethasone acetate (Dex) encapsulated into poly(thioketal) polymers form polymeric nanoparticles (NPs) (PTKNPs@Dex). The NPs were composed poly(1,4-phenyleneacetonedimethylene thioketal) (PPADT) and polythioketal urethane (PTKU), in which thioketal bonds could be cleaved by high level ROS at ALI site. PTKNPs@Dex accumulate pulmonary sites release payloads rapidly, decreased level, less generation pro-inflammatory cytokines, reduced mortality mice. RNA sequencing (RNA-seq) analysis showed that efficacy modulation many immune inflammation-linked pathways. These findings provide newly efficient treatment

Language: Английский

Citations

82
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury DOI Creative Commons
Ruijing Zhao, Lina Wang, Tian Wang

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 214 - 230

Published: March 18, 2022

Mesenchymal stem cell-derived small extracellular vesicles (MSC-EVs) are promising nanotherapeutic agent for pneumonia (bacterial origin, COVID-19), but the optimal administration route and potential mechanisms of action remain poorly understood. This study compared MSC-EVs via inhalation tail vein injection treatment acute lung injury (ALI) determined host-derived that may contribute to therapeutic effects in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (macrophage cell line) animal models. Luminex liquid chip hematoxylin eosin (HE) staining revealed that, with vehicle control, inhaled outperformed those injected vein, by reducing expression pro-inflammatory cytokines, increasing anti-inflammatory cytokine, decreasing pathological scores ALI. MSC-EV promoted polarization macrophages towards a M2 phenotype vitro vivo (via inhalation). RNA sequencing immune redox mediators, including TLR4, Arg1, HO-1, were associated activity against ALI mice. Western blotting immunofluorescence correlative inflammatory oxidative mediators involved LPS-stimulated Moreover, variable Nrf2 was observed following models, knockdown attenuated antioxidant activities macrophages. Together, these data suggest as noninvasive strategy attenuation ALI, adaptive regulation their anti-oxidant

Language: Английский

Citations

71
A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century DOI
Jingyu Wang, Wenling Zhao, Zhao Zhang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 17, 2024

Abstract Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer chronic diseases promote growth nanomedicine. However, there are very few analytical descriptive studies regarding trajectory nanomedicine, key research powers, present landscape, focal investigative points, future outlooks. Herein, articles reviews published Science Citation Index Expanded Web Core Collection from first January 2000 to 18th July 2023 analyzed. a bibliometric visualization publication trends, countries/regions, institutions, journals, categories, themes, references, keywords is produced elaborated. Nanomedicine‐related academic output increasing since COVID‐19 pandemic, solidifying uneven global distribution performance. While China leads terms quantity has numerous highly productive USA advantages impact, commercialization, industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, which drug delivery nanoparticles remain points. Current focuses on integrating nanomedicine cell ferroptosis induction immunotherapy. The keyword “burst testing” identifies promising directions, including immunogenic death, chemodynamic therapy, tumor microenvironment, immunotherapy, extracellular vesicles. prospects, major challenges, barriers addressing these directions discussed.

Language: Английский

Citations

39
Translational medicine for acute lung injury DOI Creative Commons
Jianguo Zhang,

Yumeng Guo,

Michael Mak

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 5, 2024

Abstract Acute lung injury (ALI) is a complex disease with numerous causes. This review begins discussion of development from direct or indirect pulmonary insults, as well varied pathogenesis. The heterogeneous nature ALI then elaborated upon, including its epidemiology, clinical manifestations, potential biomarkers, and genetic contributions. Although no medication currently approved for this devastating illness, supportive care pharmacological intervention treatment are summarized, followed by an assessment the pathophysiological gap between human animal models. Lastly, current research progress on advanced nanomedicines therapeutics in preclinical settings reviewed, demonstrating new opportunities towards developing effective ALI.

Language: Английский

Citations

32
Engineered mitochondrial ROS scavenger nanocomplex to enhance lung biodistribution and reduce inflammation for the treatment of ARDS DOI

Huoli Hu,

Wenjia Zhang, Yundong Zhou

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(6)

Published: Oct. 23, 2024

Language: Английский

Citations

20
More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing DOI Creative Commons
Qianmin Ou, Shaohan Zhang, Chuanqiang Fu

et al.

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Aug. 11, 2021

During wound healing, the overproduction of reactive oxygen species (ROS) can break cellular oxidant/antioxidant balance, which prolongs healing. The dressings targeting mitigation ROS will be great advantages for puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant anti-inflammatory effects. Polydopamine (PDA) is made dopamine shows excellent function. Therefore, combination antioxidants into hydrogel dressing a promising therapy healing.Hydrogel have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) polyethylene glycol diacrylate (PEG-DA) hydrogel. This load drugs retain drug in gel network long period due to presence NPs. Under oxidative stress, this improve activity superoxide dismutase glutathione peroxidase reduce levels malondialdehyde, thus preventing damage cells, then promoting tissue regeneration, collagen accumulation.Overall, triple accelerates healing alleviating injury. Our study provides new way about co-delivery molecules skin regeneration.

Language: Английский

Citations

91
Potential Application of Exosomes in Vaccine Development and Delivery DOI Open Access
Md Nurul Huda, Md Nurunnabi

Pharmaceutical Research, Journal Year: 2022, Volume and Issue: 39(11), P. 2635 - 2671

Published: Jan. 13, 2022

Language: Английский

Citations

53
The Janus of Protein Corona on nanoparticles for tumor targeting, immunotherapy and diagnosis DOI
Xiaobo Wang, Wenli Zhang

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 832 - 850

Published: March 31, 2022

Language: Английский

Citations

48
Acute lung injury caused by sepsis: how does it happen? DOI Creative Commons
Baisheng Sun, M. Lei, Jiaqi Zhang

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 21, 2023

Sepsis is a systemic inflammatory disease caused by severe infections that involves multiple organs, among which the lung most susceptible, leaving patients highly vulnerable to acute injury (ALI). Refractory hypoxemia and respiratory distress are classic clinical symptoms of ALI sepsis, has mortality rate 40%. Despite extensive research on mechanisms exact pathological process not fully understood. This article reviews advances in pathogenesis sepsis focusing treatment regimens adopted practice for corresponding molecular mechanisms. review can only contribute theories but also recommend new strategies related injuries.

Language: Английский

Citations

39
Cigarette Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers DOI Creative Commons

Sang-Ryul Cha,

Jimin Jang, Sung‐Min Park

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1210 - 1210

Published: June 3, 2023

Cigarette smoke (CS) poses a significant risk factor for respiratory, vascular, and organ diseases owing to its high content of harmful chemicals reactive oxygen species (ROS). These substances are known induce oxidative stress, inflammation, apoptosis, senescence due their exposure environmental pollutants the presence enzymes. The lung is particularly susceptible stress. Persistent stress caused by chronic CS can lead respiratory such as obstructive pulmonary disease (COPD), fibrosis (PF), cancer. Avoiding pollutants, like cigarette air pollution, help mitigate A comprehensive understanding impact on lungs requires future research. This includes identifying strategies preventing treating well investigating underlying mechanisms behind Thus, this review aims investigate cellular processes induced CS, specifically senescence, associated biomarkers. Furthermore, will delve into alveolar response provoked emphasizing roles potential therapeutic target markers in inflammation

Language: Английский

Citations

38