Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(2), P. 155 - 155
Published: Jan. 25, 2021
Nanotechnology
platforms,
such
as
nanoparticles,
liposomes,
dendrimers,
and
micelles
have
been
studied
extensively
for
various
drug
deliveries,
to
treat
or
prevent
diseases
by
modulating
physiological
pathological
processes.
The
delivery
molecules
range
from
traditional
small
recently
developed
biologics,
proteins,
peptides,
nucleic
acids.
Among
them,
proteins
shown
a
series
of
advantages
potential
in
therapeutic
applications,
introducing
due
genetic
defects,
used
nanocarriers
anticancer
agents
decelerate
tumor
growth
control
metastasis.
This
review
discusses
the
existing
nanoparticle
systems,
design
strategies,
using
each
system,
possible
limitations.
Moreover,
we
will
examine
intracellular
different
protein
therapeutics,
antibodies,
antigens,
gene
editing
into
host
cells
achieve
effects
cancer
vaccines.
Finally,
explore
current
applications
treatments.
Drug Delivery,
Journal Year:
2023,
Volume and Issue:
30(1)
Published: Feb. 28, 2023
Resveratrol
is
a
polyphenol
with
diverse
pharmacological
activities,
but
its
clinical
efficacy
limited
due
to
low
solubility/permeability,
light-induced
isomerization,
auto-oxidation,
and
rapid
metabolism.
Nanodelivery
systems,
such
as
liposomes,
polymeric
nanoparticles,
lipid
nanocarriers,
micelles,
nanocrystals,
inorganic
nanoemulsions,
protein-based
exosomes,
macrophages,
red
blood
cells
(RBCs)
have
shown
great
potential
for
improving
the
solubility,
biocompatibility,
therapeutic
of
resveratrol.
This
review
comprehensively
summarizes
recent
advances
in
resveratrol
nanoencapsulation
describes
strategies
improve
pharmacokinetics
existing
nanoformulations,
enhance
targeting,
reduce
toxicity,
increase
drug
release
encapsulation
efficiency.
The
article
also
suggests
that
order
avoid
safety
issues,
nanoformulations
must
be
tested
vivo
wide
range
diseases.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(15), P. 8825 - 9014
Published: July 25, 2024
Luminescence
imaging
is
a
powerful
and
versatile
technique
for
investigating
cell
physiology
pathology
in
living
systems,
making
significant
contributions
to
life
science
research
clinical
diagnosis.
In
recent
years,
luminescent
transition
metal
complexes
have
gained
attention
diagnostic
therapeutic
applications
due
their
unique
photophysical
photochemical
properties.
this
Review,
we
provide
comprehensive
overview
of
the
development
bioimaging
biosensing
applications,
with
focus
on
centers
d
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 571 - 608
Published: Jan. 1, 2024
Abstract:
With
the
development
of
nanotechnology,
nanoparticles
(NPs)
have
shown
broad
prospects
as
drug
delivery
vehicles.
However,
they
exhibit
certain
limitations,
including
low
biocompatibility,
poor
physiological
stability,
rapid
clearance
from
body,
and
nonspecific
targeting,
which
hampered
their
clinical
application.
Therefore,
novel
systems
with
improved
biocompatibility
high
target
specificity
remains
a
major
challenge.
In
recent
years,
biofilm
mediated
biomimetic
nano-drug
system
(BNDDS)
has
become
research
hotspot
focus
in
field
life
sciences.
This
new
platform
uses
bio-nanotechnology
to
encapsulate
synthetic
NPswithin
membrane,
organically
integrating
immunogenicity,
toxicity,
tumor
good
adjustability
versatility
nanocarrier,
shows
promising
applications
precision
therapy.
this
review,
we
systematically
summarize
progress
BNDDS
used
for
optimizing
delivery,
providing
theoretical
reference
designing
safe
efficient
treatment
strategies
improve
outcomes.
Keywords:
nanoparticles,
cell
targeted
therapy
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 3, 2024
This
study
examines
the
manufacturing,
characterization,
and
biological
evaluation
of
platinum
nanoparticles,
which
were
synthesized
by
Enterobacter
cloacae
coated
with
Bovine
Serum
Albumin
(BSA)
Resveratrol
(RSV).
The
formation
PtNPs
was
confirmed
change
color
from
dark
yellow
to
black,
due
bioreduction
chloride
E.
cloacae.
BSA
RSV
functionalization
enhanced
these
nanoparticles'
biocompatibility
therapeutic
potential.
TGA,
SEM,
XRD,
FTIR
employed
for
where
drug
conjugation-related
functional
groups
studied
FTIR.
XRD
crystalline
nature
Pt-BSA-RSV
NPs,
while
TGA
SEM
showed
thermal
stability
post-drug
coating
morphological
changes.
Designed
composite
also
found
be
biocompatible
in
hemolytic
testing,
indicating
their
potential
Biomedical
applications.
After
confirmation
based
nanocaompsite
synthesis,
they
examined
anti-bacterial,
anti-oxidant,
anti-inflammatory,
anti-cancer
properties.
NPs
higher
concentration-dependent
DPPH
scavenging
activity,
measured
antioxidant
capability.
Enzyme
inhibition
tests
demonstrated
considerable
anti-inflammatory
activity
against
COX-2
15-LOX
enzymes.
In
vitro
anticancer
studies,
effectively
killed
human
ovarian
cancer
cells.
phenomenon
facilitated
acidic
environment
cancer,
as
release
assay
NP
formulation
environment.
Finally,
Molecular
docking
that
has
strong
an
antibacterial,
agent.
Overall,
silico
investigations
current
good
medicinal
applications
designed
nanocomposites,
however,
further
in-vivo
experiments
must
conducted
validate
our
findings.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(16), P. 5052 - 5052
Published: Aug. 20, 2021
Biomimetic
nanoparticles
have
recently
emerged
as
a
novel
drug
delivery
platform
to
improve
biocompatibility
and
specificity
at
the
desired
disease
site,
especially
tumour
microenvironment.
Conventional
often
encounter
rapid
clearance
by
immune
system
poor
drug-targeting
effects.
The
development
of
nanotechnology
provides
an
opportunity
integrate
different
types
biomaterials
onto
surface
nanoparticles,
which
enables
them
mimic
natural
biological
features
functions
cells.
This
mimicry
strategy
favours
escape
biomimetic
from
reduces
potential
toxic
side
Despite
in
this
field,
not
much
has
progressed
clinical
stage.
Thus,
there
is
urgent
need
develop
biomimetic-based
nanomedicine
produce
highly
specific
effective
system,
for
malignant
tumours,
can
be
used
purposes.
Here,
recent
developments
various
are
discussed,
along
with
their
applications
cancer
imaging
treatments.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(14)
Published: Dec. 27, 2022
Artificial
enzymes
have
demonstrated
therapeutic
benefits
against
diverse
malignant
tumors,
yet
their
antitumor
potencies
are
still
severely
compromised
by
non-selective
catalysis,
low
atomic-utilization
efficiency,
and
undesired
off-target
toxicity.
Herein,
it
is
reported
that
peroxidase-like
biomineralized
copper
(II)
carbonate
hydroxide
nanocrystals
inside
single
albumin
nanocages
(CuCH-NCs)
act
as
a
pH-activatable
proenzyme
to
achieve
tumor-selective
synergistic
chemodynamic/chemo-immunotherapy
aggressive
triple-negative
breast
cancers
(TNBCs).
These
CuCH-NCs
show
pH-sensitive
Cu2+
release,
which
spontaneously
undergoes
glutathione
(GSH)-mediated
reduction
into
Cu+
species
for
catalyzing
the
evolution
of
H2
O2
hydroxyl
radicals
(·OH)
in
single-atom-like
manner
cause
chemodynamic
cell
injury,
simultaneously
activates
non-toxic
disulfiram
cytotoxic
complex
yielding
selective
chemotherapeutic
damage
via
blocking
proliferation
amplifying
apoptosis.
exhibit
considerable
tumor-targeting
capacity
with
deep
penetration
depth,
thus
affording
preferable
efficacy
orthotopic
tumors
through
chemodynamic/chemotherapy,
together
good
vivo
safety.
Moreover,
arouse
distinct
immunogenic
death
effect
upregulate
PD-L1
expression
upon
combination,
synergize
anti-PD-L1
antibody
activate
adaptive
innate
immunities,
relieving
immunosuppression,
finally
potent
both
primary
metastatic
TNBCs.
results
provide
insights
smart
high-performance
proenzymes
therapy
cancers.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(9), P. 14982 - 14999
Published: Aug. 26, 2022
Immunotherapeutic
efficacy
of
tumors
based
on
immune
checkpoint
blockade
(ICB)
therapy
is
frequently
limited
by
an
immunosuppressive
tumor
microenvironment
and
cross-reactivity
with
normal
tissues.
Herein,
we
develop
reactive
oxygen
species
(ROS)-responsive
nanocomplexes
the
function
ROS
production
for
delivery
triggered
release
anti-mouse
programmed
death
ligand
1
antibody
(αPDL1)
glucose
oxidase
(GOx).
GOx
αPDL1
were
complexed
oligomerized
(-)-epigallocatechin-3-O-gallate
(OEGCG),
which
was
followed
chelation
Fe3+
coverage
ROS-responsive
block
copolymer,
POEGMA-b-PTKDOPA,
consisting
poly(oligo(ethylene
glycol)methacrylate)
(POEGMA)
thioketal
bond-linked
dopamine
moieties
(PTKDOPA)
as
side
chains.
After
intravenous
injection,
show
prolonged
circulation
in
bloodstream
a
half-life
8.72
h
efficient
accumulation.
At
sites,
inside
can
produce
H2O2
via
oxidation
Fenton
reaction
to
generate
hydroxyl
radicals
(•OH)
further
trigger
protein
cargos
through
cleavage
bonds.
The
released
improves
efficiency
•OH
kill
cancer
cells
tumor-associated
antigens
chemodynamic
(CDT).
enhanced
immunogenic
cell
(ICD)
activate
improve
immunotherapy
effect
αPDL1,
significantly
suppresses
primary
metastatic
tumors.
Thus,
reaction-triggered
great
potentials
immunotherapeutic
ICB
combination
CDT.
