Therapeutic application of manganese-based nanosystems in cancer radiotherapy

Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122321 - 122321

Published: Sept. 11, 2023

Language: Английский

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NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100566 - 100566

Published: Jan. 29, 2023

Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated stimulator interferon genes (STING) pathway induced innate antitumor immunity. Herein, a near infrared light (NIR)-responsive nanoenzyme (PB-Mn/OVA NE) was constructed by doping manganese into ovalbumin (OVA)-templated Prussian blue (PB) nanoparticles. The resultant PB-Mn/OVA NEs exhibited favorable catalase activity produce oxygen, which conducive alleviate tumor microenvironment. Under 808 ​nm NIR irradiation, with outstanding photothermal conversion efficiency 30% significantly destroyed cells inducing immunogenic cell death (ICD). Impressively, could activate cGAS-STING promote maturation antigen cross-presentation ability dendritic (DCs), further cytotoxic T lymphocytes memory lymphocytes. Overall, this work presents powerful formula integrate ablation reversal for triggering robust adaptive response.

Language: Английский

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A Manganese‐Based Nanodriver Coordinates Tumor Prevention and Suppression through STING Activation in Glioblastoma

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 5, 2024

Glioblastoma (GBM), the most prevalent and aggressive primary malignant brain tumor, exhibits profound immunosuppression demonstrates a low response rate to current immunotherapy strategies. Manganese cations (Mn

Language: Английский

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Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(48)

Published: Oct. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Language: Английский

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A homologous-targeting cGAS-STING agonist multimodally activates dendritic cells for enhanced cancer immunotherapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 400 - 413

Published: Feb. 8, 2024

Language: Английский

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