4D Printing for Biomedical Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 5, 2024

Abstract 4D (bio‐)printing endows 3D printed (bio‐)materials with multiple functionalities and dynamic properties. materials have been recently used in biomedical engineering for the design fabrication of devices, such as stents, occluders, microneedles, smart 3D‐cell engineered microenvironments, drug delivery systems, wound closures, implantable medical devices. However, success printing relies on rational objects, selection materials, availability appropriate types external (multi‐)stimuli. Here, this work first highlights different stimuli, strategies (bio‐)printing. Then, it presents a critical review applications discusses future directions research exciting area, including vivo tissue regeneration studies, implementation reversible shape memory behaviors, creation fast shape‐transformation responses, ability to operate at microscale, untethered activation control, application (machine learning‐based) modeling approaches predict structure–property design–shape transformation relationships (bio)printed constructs.

Language: Английский

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Atomic Engineering of Single‐Atom Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 7, 2024

Single-atom nanozymes (SAzymes) showcase not only uniformly dispersed active sites but also meticulously engineered coordination structures. These intricate architectures bestow upon them an exceptional catalytic prowess, thereby captivating numerous minds and heralding a new era of possibilities in the biomedical landscape. Tuning microstructure SAzymes on atomic scale is key factor designing targeted with desirable functions. This review first discusses summarizes three strategies for their impact reactivity biocatalysis. The effects choices carrier, different synthesis methods, modulation first/second shell, type number metal centers enzyme-like activity are unraveled. Next, attempt made to summarize biological applications tumor therapy, biosensing, antimicrobial, anti-inflammatory, other from mechanisms. Finally, how designed regulated further realization diverse reviewed prospected. It envisaged that comprehensive presented within this exegesis will furnish novel perspectives profound revelations regarding SAzymes.

Language: Английский

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Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis

Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122472 - 122472

Published: Jan. 23, 2024

Language: Английский

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Biomimetic Diselenide‐Sonosensitizer Nanoplatform for Enhanced Sonodynamic Therapy and In Situ Remodeling Immunosuppressive Microenvironment via Activating Innate and Adaptive Immunotherapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Sonodynamic therapy (SDT), which is non-invasive and controllable has the potential to treat triple-negative breast cancer (TNBC). However, hypoxia immunosuppressive tumor microenvironment (TME) often block production of reactive oxygen species induction SDT-activated immunogenic cell death, thus limiting activation adaptive immune responses. To alleviate these challenges, we proposed development a multifunctional biomimetic nanoplatform (mTSeIR), was designed with diselenide-conjugated sonosensitizers tirapazamine (TPZ), encapsulated within M1 macrophage membrane. This utilized hypoxia-induced chemotherapy improve efficacy SDT, further enhance immunotherapy by activating innate immunity remodeling TME. Firstly, prodrug TPZ activated due increased consumption associated SDT. Subsequently, mTSeIR enhanced repolarization M2 macrophages phenotype. The diselenide component in effectively natural killer cell-mediated antitumor response. Ultimately, vivo studies indicated that mTSeIR+US good biosafety achieved over 98% inhibition immunotherapy. research presents an efficient approach addressed limitations SDT achieves simultaneous both immunotherapy, resulting significant anti-metastatic TNBC.

Language: Английский

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Hypoxia Reversion and STING Pathway Activation through Large Mesoporous Nanozyme for Near-Infrared-II Light Amplified Tumor Polymetallic-Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 22153 - 22171

Published: Aug. 9, 2024

cGAS/STING pathway, which is highly related to tumor hypoxia, considered as a potential target for remodeling the immunosuppressive microenvironment of solid tumors. Metal ions, such Mn2+, activate but their efficacy in cancer therapy limited by insufficient effect on immunogenic cell death single ion. Here, we evaluate association between hypoxia and inhibition report polymetallic-immunotherapy strategy based large mesoporous trimetal-based nanozyme (AuPdRh) coordinated with Mn2+ (Mn2+@AuPdRh) signaling robust adaptive antitumor immunity. Specifically, inherent CAT-like activity this polymetallic Mn2+@AuPdRh decomposes endogenous H2O2 into O2 relieve induced suppression signaling. Moreover, displays potent near-infrared-II photothermal strong POD-mimic activity; generated hyperthermia •OH radicals synergistically trigger tumors, releasing abundant dsDNA, while delivered augments sensitivity cGAS dsDNA activates cGAS-STING thereby triggering downstream immunostimulatory signals kill primary distant metastatic Our study demonstrates metal-based STING-mediated may inspire development more effective strategies immunotherapy.

Language: Английский

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Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101018 - 101018

Published: March 11, 2024

The cGAS-STING pathway holds tremendous potential as a regulator of immune responses, offering means to reshape the tumor microenvironment and enhance immunotherapy. Despite emergence STING agonists, their clinical viability is hampered by stability delivery challenges, well variations in expression within tumors. In this study, we present Mn-phenolic networks novel carrier for ADU-S100, hydrophilic agonist, aimed at bolstering These nanoparticles, termed TMA NMs, are synthesized through coordination tannic acid manganese ions, with surface modification involving bovine serum albumin colloidal stability. NMs exhibit pH/GSH-responsive disintegration properties, enabling precise drug release. This effectively addresses issues facilitates efficient intracellular delivery. Importantly, synergistically effects ADU-S100 concurrent release Mn2+, which serves sensitizer pathway, resulting significant activation. Upon systemic administration, these nanoparticles efficiently accumulate activation pathways not only induces immunogenic cell death (ICD) cells but also orchestrates remodeling immunosuppressive microenvironment. includes promotion cytokine release, dendritic maturation, T infiltration, leading pronounced suppression growth. Combining excellent biocompatibility biodegradability, Mn-based nanocarrier represents promising strategy enhancing immunotherapy pathway.

Language: Английский

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Outer membrane vesicle-wrapped manganese nanoreactor for augmenting cancer metalloimmunotherapy through hypoxia attenuation and immune stimulation

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 402 - 414

Published: May 9, 2024

Language: Английский

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Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 181 - 198

Published: July 5, 2023

Summary Immunogenic cell death (ICD) is a special pattern of tumor death, enabling to elicit tumor‐specific immune response via the release damage‐associated molecular patterns and tumor‐associated antigens in microenvironment. ICD‐induced immunotherapy holds promise for completely eliminating tumors long‐term protective antitumor response. Increasing ICD inducers have been discovered boosting immunity evoking ICD. Nonetheless, utilization remains insufficient owing serious toxic reactions, low localization efficiency within microenvironmental niche, etc. For overcoming such limitations, stimuli‐responsive multifunctional nanoparticles or nanocomposites with developed improving immunotherapeutic lowering toxicity, which represent prospective scheme fostering immunotherapy. This review outlines advances near‐infrared (NIR)‐, pH‐, redox‐, pH‐ NIR‐ microenvironment‐responsive nanodelivery systems induction. Furthermore, we discuss their clinical translational potential. The progress settings depends upon development biologically safer drugs tailored patient needs. Moreover, an in‐depth comprehending biomarkers, immunosuppressive microenvironment, may accelerate advance smarter further amplify

Language: Английский

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Diagnosing Orthotopic Lung Tumor Using a NTR-Activatable Near-Infrared Fluorescent Probe by Tracheal Inhalation

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(38), P. 14402 - 14412

Published: Sept. 12, 2023

Nitroreductase (NTR) is an enzyme that upregulated under tumor-depleted oxygen conditions. The majority of studies have been conducted on NTR, but many existing fluorescent imaging tools for monitoring NTR inevitably suffer from weak targeting, low sensitivity, and simple tumor models. Research diagnosing lung tumors has very popular in recent years, targeting assays orthotopic still great research value, as such models better mimic the reality cancer organism. Here, we developed a novel near-infrared (NIR) probe IR-ABS jointly targets carbonic anhydrase IX (CAIX). excellent sensitivity selectivity shows exceptional response spectroscopic tests. measurements ensured this good biosafety both cells mice. A was found hypoxic at cellular level, distinguishing normal cells. In vivo experiments demonstrated achieves zebrafish level enables rapid accurate margin distinguishment different mouse More importantly, successfully applied detection models, further combined with tracheal inhalation drug delivery to improve targeting. To best our knowledge, present first time method cancerous situ via delivery, contrast reported literature. This NIR fluorescence diagnostic strategy holds exciting potential clinical aid diagnosis.

Language: Английский

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Nanoparticle targeting cGAS-STING signaling in disease therapy

Nano Research, Journal Year: 2024, Volume and Issue: 17(8), P. 7315 - 7336

Published: June 15, 2024

Language: Английский

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