Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis DOI Creative Commons

Florina Veider,

Eva Sanchez Armengol, Andreas Bernkop‐Schnürch

et al.

Small, Journal Year: 2023, Volume and Issue: 20(3)

Published: Sept. 7, 2023

Abstract The past two decades have witnessed a rapid progress in the development of surface charge‐reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able to elegantly address polycation dilemma. Converting their charge from negative/neutral positive at target site, they can substantially improve drugs diagnostic agents. By specific stimuli like shift pH redox potential, enzymes, or exogenous such as light heat, reversal NP be achieved site. activated enhances adhesion cells facilitates cellular uptake, endosomal escape, mitochondrial targeting. Because these properties, efficacy incorporated well sensitivity agents essentially enhanced. Furthermore, shown overcome biofilm formed by pathogenic bacteria shuttle antibiotics directly cell membrane microorganisms. In this review, up‐to‐date design emerging applications diagnosis highlighted.

Language: Английский

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration DOI
Xu Zhao, Yujing Liu, Rui Ma

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(12), P. 14059 - 14071

Published: March 17, 2022

Diabetic foot ulcer is a serious complication in diabetes patients, imposing physical and economic burden to patients the healthcare system as whole. Oxidative stress thought be key driver of pathogenesis such ulcers. However, no antioxidant drugs have received clinical approval date, underscoring need for further development medications. Hydrogels can applied directly wound site, wherein they function prevent infection maintain local moisture concentrations, addition serving reservoir delivery range therapeutic compounds with potential expedite healing synergistic manner. Herein, we synthesized Prussian blue nanoparticles (PBNPs) capable efficiently scavenging reactive oxygen species (ROS) owing their ability mimic activity catalase (CAT), peroxidase (POD), superoxide dismutase (SOD). In context vitro oxidative stress, these PBNPs were able protect against cytotoxicity, mitochondria from stress-related damage, restore nuclear factor erythroid 2-related 2 (NRF2)/heme oxygenase-1 (HO-1) pathway activity. To expand on results an vivo context, prepared thermosensitive poly (d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA) hydrogel (PLEL)-based dressing which had been homogenously incorporated, then used this platform controlled PBNP release. The resultant PBNPs@PLEL was improve diabetic healing, decrease ROS production, promote angiogenesis, reduce pro-inflammatory interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) levels within wounds. Overall, our suggest that holds great promise treatment

Language: Английский

Citations

142
Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design DOI Creative Commons
Zimu Li, Zhidong Chen, Hongzhong Chen

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 49 - 70

Published: Feb. 1, 2022

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment motor system injury, digestive disease, oculopathy, bioelectronics. In this review, starting with the classification common hydrogels, pyramid evolution process from structures derived then applications is elaborated, well efficient reverse design considerations hydrogel systems are proposed. Finally, existing problems development prospects these materials discussed. It hoped that perspective review can promote further innovation breakthroughs future.

Language: Английский

Citations

127
Heterojunction engineered bioactive chlorella for cascade promoted cancer therapy DOI

Meitong Ou,

Chuchu Lin,

Ying Wang

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 755 - 769

Published: April 2, 2022

Language: Английский

Citations

120
Tumor-Generated Reactive Oxygen Species Storm for High-Performance Ferroptosis Therapy DOI
Lin Huang,

Jiaoyang Zhu,

Wei Xiong

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11492 - 11506

Published: June 7, 2023

Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the tumor environment (TME), which are unfavorable for reactive oxygen species (ROS) generation based on or Fenton-like reactions. The glutathione (GSH) overexpression TME can scavenge ROS abate FT performance. In this study, strategy storm specifically initiated by our developed nanoplatforms (TAF-HMON-CuP@PPDG) is proposed high-performance tumors. GSH initiates HMON degradation, resulting tamoxifen (TAF) copper (CuP) release TAF3-HMON-CuP3@PPDG. released TAF leads to enhanced acidification within cells, reacts with CuP producing Cu2+ H2O2. reaction between H2O2 generates Cu+, that Cu+ Cu2+, forming cyclic catalysis effect. generate GSSG. increased accelerate consumption decreases peroxidase 4 (GPX4) expression. All above reactions cells FT, demonstrated cancer tumor-bearing mice.

Language: Английский

Citations

118
Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy DOI Creative Commons

ZhangPing Li,

Shengye You, Ruiting Mao

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 15, P. 100264 - 100264

Published: April 20, 2022

Polydopamine nanoparticles (PDA NPs) are an appealing biomimetic photothermal agent for antibacterial treatment because of their long-term safety, excellent photostability, accessible manufacturing, and good biodegradability. However, the low conversion efficiency (PCE) PDA NPs requires high-power near-infrared light irradiation, which severely restricts practical application. In this work, PDA@Cu were fabricated by growing Cu in situ on surface then introduced into a polyelectrolyte hydrogel precursor (cationic polyethyleneimine/anionic pectin, named as CPAP). The formulated platform possessed high PCE (55.4%), almost twice much pure (30.8%). Moreover, designed CPAP/PDA@Cu captured killed some bacteria electrostatic adsorption, helped enhance performance. As expected, formed that combined advantageous features (high PCE) CPAP matrix (inherent activity preventing aggregation) can efficiently kill both vitro vivo under help laser irradiation. Taken together, study offers promising strategy constructing facile safe PDA-based therapy.

Language: Английский

Citations

94
Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications DOI Creative Commons
Ranjith Kumar Kankala,

Yahui Han,

Hong‐Ying Xia

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: March 12, 2022

Despite exceptional morphological and physicochemical attributes, mesoporous silica nanoparticles (MSNs) are often employed as carriers or vectors. Moreover, these conventional MSNs suffer from various limitations in biomedicine, such reduced drug encapsulation efficacy, deprived compatibility, poor degradability, resulting therapeutic outcomes. To address limitations, several modifications have been corroborated to fabricating hierarchically-engineered terms of tuning the pore sizes, modifying surfaces, engineering siliceous networks. Interestingly, further advancements engineered lead generation highly complex nature-mimicking structures, Janus-type, multi-podal, flower-like architectures, well streamlined tadpole-like nanomotors. In this review, we present explicit discussions relevant advanced hierarchical architectures different fields including delivery, bioimaging, tissue engineering, miscellaneous applications, photoluminescence, artificial enzymes, peptide enrichment, DNA detection, biosensing, among others. Initially, give a brief overview diverse, innovative stimuli-responsive (pH, light, ultrasound, thermos)- targeted delivery strategies, along with on recent cancer immune therapy applicability other ailments related cardiac, vascular, nervous systems, diabetes. Then, provide initiatives taken so far clinical translation silica-based materials their scope towards translation. Finally, summarize review interesting perspectives lessons learned exploring biomedical applications requirements be explored.

Language: Английский

Citations

86
Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives DOI
Hongwei Xu, Ying Zhang, Haotian Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 488, P. 215153 - 215153

Published: April 27, 2023

Language: Английский

Citations

85
New opportunities and old challenges in the clinical translation of nanotheranostics DOI
Peter J. Gawne, Miguel Ferreira,

Marisa Papaluca

et al.

Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(12), P. 783 - 798

Published: July 26, 2023

Language: Английский

Citations

81
Multifunctional Mesoporous Polydopamine‐Based Systematic Delivery of STING Agonist for Enhanced Synergistic Photothermal‐Immunotherapy DOI
Wenfeng Zeng, Zimu Li, Qili Huang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(1)

Published: Sept. 15, 2023

Abstract The therapeutic application of STING agonists in various malignancies has been limited by factors such as the inability systemic administration and immunosuppressive tumor microenvironment. Herein, this work reports a mesoporous polydopamine‐based multifunctional nanoplatform loaded with agonist MSA‐2 chelated Mn 2+ for synergistic photothermal activation‐based immunotherapy. effectively delivers to site intelligently releases its contents through acid degradation, facilitated effect. Additionally, thermal ablation tissue can induce immunogenic cell death, which helps alleviate microenvironment, thereby enhancing efficacy MSA‐2. Furthermore, works dual‐acting sensitizer MRI contrast agent not only boosts immune response but also allows real‐time tracking nanoplatform. This strategy is proved highly efficacious both impeding primary/metastatic eliciting robust tumor‐specific response. Collectively, an effective delivery synergized therapy pathway activation‐mediated immunotherapy highlighted here provide new ideas strategies optimizing combination cancer treatment.

Language: Английский

Citations

64
Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy DOI
Ping Huang, Yao Yang, Wenyan Wang

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 299, P. 122157 - 122157

Published: May 9, 2023

Language: Английский

Citations

59