Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123238 - 123238
Published: March 6, 2025
Language: Английский
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 5, 2025
ABSTRACT To improve the long‐term therapeutic efficacy of colorectal cancer, we propose a synergistic treatment strategy involving dual‐pathway, multistep induction hyperimmunity combined with photothermal‐chemotherapy. implement this strategy, infinite coordination polymer nanoparticles (SN38‐Mn(II)‐EGCG ICP NPs) were prepared by coordinating SN38, EGCG, and Mn 2+ . These then coated polydopamine (PDA) grafted folate‐PEG‐thiol (FA‐PEG‐SH) onto their surfaces, producing tumor‐targeting folate‐modified PDA nanocomposites (ICP@FA‐PDA nanocomposites). exhibit particle size 94.9 ± 1.6 nm high drug loading capacity (83.3% 1.5%), release under acidic conditions while maintaining stability in physiological environments. Furthermore, each component within serves multiple functions. Notably, incorporation components triggers powerful antitumor immune effect establishes enduring memory through dual‐pathway approach, which is produced activation cGAS‐STING pathway immunogenic cell death (ICD) four‐component process. Under low‐dose regimen, approach induces generates ultra‐long immunological memory, marked ninefold increase CD8 + T infiltration, fourfold CD4 lymphocytes, reduction Treg cells, fivefold cells. The remarkable therapy achieved combination SN38 EGCG chemotherapy photothermal therapy. In vivo studies demonstrated that mice treated ICP@FA‐PDA complete eradication cancer 21 days, no recurrence observed 60 days. hold significant promise potential for future clinical translation.
Language: Английский
Citations
3
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.
Language: Английский
Citations
3
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 914 - 927
Published: Feb. 9, 2024
Language: Английский
Citations
13
Biomaterials, Journal Year: 2024, Volume and Issue: 310, P. 122628 - 122628
Published: May 28, 2024
Language: Английский
Citations
12
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)
Published: July 17, 2024
Meticulously engineered nanomaterials achieve significant advances in the diagnosis and therapy of solid tumors by improving tumor delivery efficiency; thereby, enhancing imaging therapeutic efficacy. Currently, polydopamine (PDA) attracts widespread attention because its biocompatibility, simplicity preparation, abundant surface groups, high photothermal conversion efficiency, which can be applied drug delivery, therapy, theranostics, other nanomedicine fields. Inspired PDA structures that are rich catechol amino functional groups coordinate with various metal ions, have charming qualities characteristics, metal-coordinated exploited for but not thoroughly summarized. Herein, this review summarizes recent progress fabrication their availabilities further in-depth discussion challenges future perspectives structures, aim systematic promote interdisciplinary intersections provide inspiration growth clinical translation materials.
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131359 - 131359
Published: April 4, 2024
Language: Английский
Citations
9
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 273 - 287
Published: June 1, 2024
Language: Английский
Citations
9
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The resection of bone tumors results in large defects with some residual tumor cells, and the treatment this type defect area often faces a dilemma, namely, trade-off between repair antitumor after tumors. In order to promote local repair, at same time inhibit recurrence by continuous controlled drug administration, we developed multifunctional NIR-responsive scaffold, whose main components are polylactic acid MXene, loaded PLGA/DOX microspheres, hope that scaffold can take into account both bidirectional modulation effect NIR. showed 1% MXene content had relatively good performance photothermal therapy (PT) other aspects, it could be smoothly increased 50 °C within 2 min under NIR illumination, release microspheres was 10% illumination compared body temperature. vivo experiments animals effectively limited situ cells lung metastasis able osteogenic differentiation irradiation. Therefore, not only control drugs but also enhance through PT formation, which provides application solution for integrated surgery.
Language: Английский
Citations
1
ACS Applied Engineering Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Breast cancer is one of the most common cancers in world. Surgery preferred treatment for this cancer, but risk local recurrence and metastasis remaining cells after surgery still a significant concern. A coculture 3D model based on dopamine-grafted alginate (Alg-DA) containing different polydopamine nanoparticles (PDA NPs) presented work breast cell therapy. The PDA NPs were grown situ hydrogels to fabricate ADHG-PDAN-x hydrogels, which x indicates NP content. human line MDA-MB-231 primary foreskin fibroblast (HFF) cocultured closely resemble vivo tumor microenvironment. hydrogel models treated by applying an anticancer drug, docetaxel (chemotherapy), near-infrared (NIR) irradiation using laser with 808 nm wavelength power 1 W/cm2 (photothermal therapy), combination both methods (chemo-photothermal therapy). results unveiled increased effect chemo-photothermal therapy 67.4% eradication cancerous cells, while only chemotherapy photothermal showed 48.4% 57.8% rates, respectively. This therapeutic method can potentially prevent growth be used eliminate residual cells.
Language: Английский
Citations
1
Composites Part B Engineering, Journal Year: 2025, Volume and Issue: 297, P. 112252 - 112252
Published: Feb. 18, 2025
Language: Английский
Citations
1