Nanocarrier based Strategies to Deliver Plant- Derived Bioactive Phytoconstituents for Cancer Treatment: A Comprehensive Review

Published: April 30, 2025

This comprehensive review highlights the recent advances in nanocarrier-mediated delivery of plant-derived phytoconstituents for cancer treatment. Various nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanostructured carriers, dendrimers, nanoemulsions, and metallic nanoparticles are discussed terms their design, functionalization, role improving pharmacokinetics, stability, tumor targeting, controlled release phytoconstituents. The synergistic potential co-delivery systems, surface modification strategies (e.g., PEGylation, ligand conjugation), stimuli-responsive also elaborated. Furthermore, explores vitro vivo studies demonstrating enhanced anticancer efficacy, reduced systemic toxicity, improved therapeutic index via nano delivery. Key challenges clinical translation large-scale manufacturing, regulatory approval, safety profiling addressed along with future directions. Overall, nanocarrier-based represent a promising frontier integrating phytomedicine into mainstream oncology, enabling targeted, safe, effective therapy. aims to provide researchers, formulators, clinicians foundational understanding nanotechnological advancements driving next generation plant-based therapeutics.

Language: Английский

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Nanotechnology-mediated precision drug delivery strategies for breast cancer treatment

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 188, P. 118224 - 118224

Published: June 1, 2025

Language: Английский

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Construction of WS2/Au-lipid drug delivery system for multiple combined therapy of tumor

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 76, P. 103747 - 103747

Published: Aug. 28, 2022

Language: Английский

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Nanocrystals: An Approachable Delivery System for Anticancer Therapeutics

Current Drug Metabolism, Journal Year: 2022, Volume and Issue: 23(8), P. 603 - 615

Published: June 15, 2022

Cancer accounts for the high mortality rate and limits life expectancy of an individual. As per WHO report 2020, cancer >10 million deaths globally. Scientists are continuously pitching toward development novel techniques to combat this menace enhance efficacy prevailing molecules. In early phases drug process, >40% promising new therapeutic molecules hydrophobic. Low aqueous solubility results in compromised bioavailability on administration. This limitation is a major drawback use anticancer drugs. Drug nanocrystals (NCs) have sparked lot interest delivery. might be due their excellent physicochemical characteristics like tailored dissolution, loading efficiency, extended circulation period, structural stability. There 'n' number that make formulation treatment cancer. last few years, many hydrophobic or lipophilic drugs camptothecin, paclitaxel, cyclosporin, busulfan, thymectacin been formulated as against therapeutics. Various technologies developed conjunction with nanocrystal development. includes top-down approaches, bottom-up well combination technology. article, we will focus various manufacturing processes, biological fate applications NCs, future perspectives management

Language: Английский

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Fisetin nanoparticles based on cells cycle and apoptosis intervention for the treatment of lymphoma and leukemia

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 654, P. 123971 - 123971

Published: March 6, 2024

Language: Английский

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