International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2441 - 2467
Published: March 1, 2024
Abstract:
New
nanotechnology
strategies
for
enhancing
drug
delivery
in
brain
disorders
have
recently
received
increasing
attention
from
designers.
The
treatment
of
neurological
conditions,
including
tumors,
stroke,
Parkinson's
Disease
(PD),
and
Alzheimer's
disease
(AD),
may
be
greatly
influenced
by
nanotechnology.
Numerous
studies
on
neurodegeneration
demonstrated
the
effective
application
nanomaterials
illnesses.
Nanocarriers
(NCs)
made
it
easier
to
deliver
drugs
precisely
where
they
are
needed.
Thus,
most
use
is
various
diseases,
as
this
amplifies
overall
impact
medication
emphasizes
significance
nanotherapeutics
through
gene
therapy,
enzyme
replacement
blood-barrier
mechanisms.
Recent
advances
led
development
multifunctional
nanotherapeutic
agents,
a
promising
disorders.
This
novel
method
reduces
side
effects
improves
outcomes.
review
critically
assesses
efficient
nano-based
systems
light
obstacles
outstanding
achievements.
that
transfer
medications
across
blood-brain
barrier
nano-assisted
therapies,
nano-immunotherapy,
nano-gene
nano
scaffolds,
3D
6D
printing,
been
widely
explored
study
aimed
evaluate
existing
literature
regarding
can
penetrate
(BBB)
therapeutic
agents
treat
Keywords:
delivery,
nanomedicine,
nano-therapeutics,
nanocarriers,
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
13, P. 100208 - 100208
Published: Jan. 1, 2022
Nanotechnology
in
medical
applications,
especially
oncology
as
drug
delivery
systems,
has
recently
shown
promising
results.
However,
although
these
advances
have
been
the
pre-clinical
stages,
clinical
translation
of
this
technology
is
challenging.
To
create
systems
with
increased
treatment
efficacy
for
translation,
physicochemical
characteristics
nanoparticles
such
size,
shape,
elasticity
(flexibility/rigidity),
surface
chemistry,
and
charge
can
be
specified
to
optimize
efficiency
a
given
application.
Consequently,
interdisciplinary
researchers
focused
on
producing
biocompatible
materials,
production
technologies,
or
new
formulations
efficient
loading,
high
stability.
The
effects
design
parameters
studied
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(27)
Published: April 11, 2022
An
approach
of
decorating
bacteria
with
triple
immune
nanoactivators
is
reported
to
develop
tumor-resident
living
immunotherapeutics.
Under
cytocompatible
conditions,
tumor-specific
antigens
and
checkpoint
blocking
antibodies
are
simultaneously
conjugated
onto
bacterial
surface
then
polydopamine
nanoparticles
formed
via
in
situ
dopamine
polymerization.
In
addition
serving
as
a
linker,
its
photothermal
effect
can
repolarize
tumor-associated
macrophages
pro-inflammatory
phenotype.
The
linked
promote
the
maturation
dendritic
cells
generate
responses,
while
anchored
block
checkpoints
activate
cytotoxic
T
lymphocytes.
Decorated
show
spatiotemporal
tumor
retention
proliferation-dependent
drug
release,
achieving
potent
antitumor
effects
two
antigen-overexpressing
models.
This
work
provides
versatile
platform
prepare
multimodal
long-acting
therapeutics
for
cancer
immunotherapy.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(12), P. 2868 - 2868
Published: June 10, 2022
The
enhanced
permeability
and
retention
(EPR)
effect
in
cancer
treatment
is
one
of
the
key
mechanisms
that
enables
drug
accumulation
at
tumor
site.
However,
despite
a
plethora
virus/inorganic/organic-based
nanocarriers
designed
to
rely
on
EPR
effectively
target
tumors,
most
have
failed
clinic.
It
seems
non-compliance
research
activities
with
clinical
trials,
goals
unrelated
effect,
lack
awareness
impact
solid
structure
interactions
performance
intensified
this
dissatisfaction.
As
such,
asymmetric
growth
structural
complexity
physicochemical
properties
nanocarriers,
analytical
combination
tools,
description
should
be
considered
improve
EPR-based
therapeutics.
This
review
provides
valuable
insights
into
limitations
therapeutic
efficacy
reports
crucial
perspectives
how
can
modulated
effects
nanomedicine.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 16, 2024
Abstract
The
intratumoral
injection
of
therapeutic
agents
responsive
to
external
stimuli
has
gained
considerable
interest
in
treating
accessible
tumors
due
its
biocompatibility
and
capacity
reduce
side
effects.
For
the
first
time,
a
novel
approach
is
explored
investigate
feasibility
utilizing
low-intensity
ultrasound
combination
with
drug-loaded
magnetic
nanoparticles
(MNPs)
thermal
necrosis
chemotherapy
objective
maximizing
tumor
damage
while
avoiding
harm
surrounding
healthy
tissue.
In
this
study,
mathematical
framework
proposed
based
on
multi-compartment
model
evaluate
effects
transducer’s
specifications,
MNPs
size
distribution,
drug
release
response
microenvironment
characteristics.
results
indicate
that
higher
rate
may
increase
interstitial
fluid
pressure,
it
also
simultaneously
enhances
concentration
agent.
Moreover,
by
increasing
power
frequency
transducer,
acoustic
pressure
intensity
can
be
enhanced.
This,
turn,
increases
impact
accumulated
MNPs,
resulting
rise
temperature
localized
heat
generation.
Results
have
demonstrated
smaller
lower
generate
compared
larger
primarily
sound
waves
them.
It
worth
noting
been
observed
enhanced
diffusion,
allowing
them
effectively
spread
within
tumor.
However,
their
leads
rapid
elimination
from
extracellular
space
into
bloodstream.
To
summarize,
study
local
carrying
drugs
not
only
enables
but
effectiveness
inducing
tissue
necrosis.
findings
serve
as
valuable
reliable
resource
for
future
research
field
contribute
development
personalized
medicine.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: July 11, 2024
Cancer,
being
one
of
the
deadliest
diseases,
poses
significant
challenges
despite
existence
traditional
treatment
approaches.
This
has
led
to
a
growing
demand
for
innovative
pharmaceutical
agents
that
specifically
target
cancer
cells
effective
treatment.
In
recent
years,
use
metal
nanoparticles
(NPs)
as
promising
alternative
conventional
therapies
gained
prominence
in
research.
Metal
NPs
exhibit
unique
properties
hold
tremendous
potential
various
applications
Studies
have
demonstrated
certain
metals
possess
inherent
or
acquired
anticancer
capabilities
through
their
surfaces.
These
make
an
attractive
focus
therapeutic
development.
this
review,
we
will
investigate
applicability
several
distinct
classes
tumor
targeting
may
include
gold,
silver,
iron
oxide,
and
other
with
can
be
exploited
purposes.
Additionally,
provide
comprehensive
summary
risk
factors
associated
application
NPs.
Understanding
addressing
these
crucial
successful
clinical
translation
mitigate
any
failures
NP-based
therapies.
By
exploring
identifying
factors,
review
aims
contribute
advancement
strategies.
The
anticipated
outcome
is
valuable
insights
pave
way
targeted
utilizing
patients.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(3), P. 495 - 511
Published: Feb. 24, 2024
Breast
cancer
is
a
global
health
concern
that
demands
attention.
In
our
contribution
to
addressing
this
disease,
study
focuses
on
investigating
wireless
micro-device
for
intratumoral
drug
delivery,
utilizing
electrochemical
actuation.
Microdevices
have
emerged
as
promising
approach
in
field
due
their
ability
enable
controlled
injections
various
applications.
