In Situ Formation of Fibronectin‐Enriched Protein Corona on Epigenetic Nanocarrier for Enhanced Synthetic Lethal Therapy DOI Creative Commons
Zhangyi Luo, Zhuoya Wan, Pengfei Ren

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(19)

Published: March 14, 2024

Abstract PARP inhibitors (PARPi)‐based synthetic lethal therapy demonstrates limited efficacy for most cancer types that are homologous recombination (HR) proficient. To potentiate the PARPi application, a nanocarrier based on 5‐azacytidine (AZA)‐conjugated polymer (PAZA) codelivery of AZA and inhibitor, BMN673 (BMN) is developed. conjugation significantly decreased nanoparticle (NP) size increased BMN loading. Molecular dynamics simulation experimental validations shed mechanistic insights into self‐assembly effective NPs. The small PAZA NPs demonstrated higher efficiency tumor targeting penetration than larger NPs, which mediated by new mechanism active involves recruitment fibronectin from serum proteins following systemic administration Furthermore, it found carrier sensitize HR‐proficient nonsmall cell lung (NSCLC) to BMN, combination more at lower AZA/BMN dosage. investigate underlying mechanism, immune microenvironment various gene expressions RNAseq explored. Moreover, BMN/PAZA immunogenicity synergized with PD‐1 antibody in improving overall therapeutic effect an orthotopic model (LLC).

Language: Английский

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance DOI
Mingze Xu,

Yuming Qi,

G.H. Liu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

Citations

199
Stimuli-activatable nanomedicine meets cancer theranostics DOI Creative Commons
Haonan Li, Feng Yue, Qiang Luo

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

Citations

147
Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy DOI

Qimeng Wu,

Yang Hu, Bing Yu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 19 - 43

Published: Aug. 24, 2023

Language: Английский

Citations

53
Nanomedomics DOI

Ganghao Liang,

Wanqing Cao, Dongsheng Tang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

Citations

30
Nanotechnology development in surgical applications: recent trends and developments DOI Creative Commons
Farzad Abaszadeh, Muhammad Hossein Ashoub,

Ghazal Khajouie

et al.

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Nov. 24, 2023

Abstract This paper gives a detailed analysis of nanotechnology's rising involvement in numerous surgical fields. We investigate the use nanotechnology orthopedic surgery, neurosurgery, plastic oncology, heart vascular ophthalmic thoracic and minimally invasive surgery. The details how helps with arthroplasty, chondrogenesis, tissue regeneration, wound healing, more. It also discusses employment nanomaterials implant surfaces, bone grafting, breast implants, among other things. article explores various uses, including stem cell-incorporated nano scaffolds, nano-surgery, hemostasis, nerve nanorobots, diagnostic applications. ethical safety implications using surgery are addressed. future possibilities investigated, pointing to possible route for improved patient outcomes. essay finishes comment on transformational influence applications its promise breakthroughs. Graphical

Language: Английский

Citations

38
Nanomaterial‐Enabled Photothermal Heating and Its Use for Cancer Therapy via Localized Hyperthermia DOI Open Access
Song Shen, Jichuan Qiu, Da Huo

et al.

Small, Journal Year: 2023, Volume and Issue: 20(7)

Published: Oct. 6, 2023

Abstract Photothermal therapy (PTT), which employs nanoscale transducers delivered into a tumor to locally generate heat upon irradiation with near‐infrared light, shows great potential in killing cancer cells through hyperthermia. The efficacy of such treatment is determined by number factors, including the amount, distribution, and dissipation generated heat, as well type cell involved. amount largely controlled accumulated inside tumor, absorption coefficient photothermal conversion efficiency transducer, irradiance light. depends on distribution penetration depth vascularity tissue thermal conduction both affect thereby temperature. successful implementation PTT clinic setting critically techniques for real‐time monitoring management

Language: Английский

Citations

27
Engineering Ultra‐Small Cerium‐Based Metal–Organic Frameworks Nanozymes for Efficient Antioxidative Treatment of Dry Eye Disease DOI
Zhongxing Chen, Zheng Li, Nana Tang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(6)

Published: Dec. 6, 2023

Abstract Dry eye disease (DED) is a widespread ophthalmic illness that inflicts massive economic and medical burdens on society. Although oxidative stress closely associated with the onset of DED, barely any quantities antioxidants are clinically available owing to low efficiency, toxicity, poor bioavailability. Cerium‐based nanozymes possess promising enzyme‐mimetic activities in scavenging reactive oxygen species (ROS). Moreover, ultra‐small metal–organic frameworks (MOFs) have potential for more efficient drug delivery, ROS elimination, therapeutic efficacy. However, development cerium‐based MOFs (Ce‐MOFs) limited small minority due challenges synthetic process stability. By simply adjusting raw ingredients concentrations, three types Ce‐MOFs distinct particle sizes synthesized: Ce‐MOF 1 (213 nm), 2 (36 3 (2 nm). In comparison, obtained exhibited superior antioxidant capacity, decreased cytotoxicity, excellent ocular penetration. Therapeutically, demonstrated be highly alleviating DED by suppressing inflammation, boosting corneal epithelial repair, facilitating tear secretion recovery. The novel may serve as alternative treatment other ROS‐related disorders when combined biocompatibility.

Language: Английский

Citations

24
Zinc‐Based ROS Amplifiers Trigger Cancer Chemodynamic/Ion Interference Therapy Through Self‐Cascade Catalysis DOI
Yun Sun, Liting Qin, Yuhan Yang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract Nanozyme‐mediated chemodynamic therapy has emerged as a promising strategy due to its tumor specificity and controlled catalytic activity. However, the poor efficacy caused by low hydrogen peroxide (H 2 O ) levels in microenvironment (TME) poses challenges. Herein, an H self‐supplying nanozyme is constructed through loading peroxide‐like active platinum nanoparticles (Pt NPs) on zinc (ZnO (denoted ZnO @Pt). releases response acidic TME. Pt NPs catalyze hydroxyl radical generation from while reducing mitigation of oxidative stress glutathione, serving reactive oxygen (ROS) amplifier self‐cascade catalysis. In addition, Zn 2+ released interferes with cell energy supply metabolism, enabling ion interference synergize therapy. vitro studies demonstrate that @Pt induces cellular injury enhanced ROS release, downregulating ATP NAD + levels. vivo assessment anticancer effects showed could generate at sites induce apoptosis downregulate pathways associated glycolysis, resulting 89.7% reduction growth. This study presents TME‐responsive capable self‐supply therapy, providing paradigm for tumor‐specific design.

Language: Английский

Citations

12
Lenvatinib in hepatocellular carcinoma: Resistance mechanisms and strategies for improved efficacy DOI
Y. Qin, Shisong Han, Yahan Yu

et al.

Liver International, Journal Year: 2024, Volume and Issue: 44(8), P. 1808 - 1831

Published: May 3, 2024

Hepatocellular carcinoma (HCC), one of the most prevalent and destructive causes cancer-related deaths worldwide, approximately 70% patients with HCC exhibit advanced disease at diagnosis, limiting potential for radical treatment. For such patients, lenvatinib, a long-awaited alternative to sorafenib first-line targeted therapy, has become key Unfortunately, despite some progress, prognosis remains poor because drug resistance development. However, molecular mechanisms underlying lenvatinib ways relief in are largely unknown lack systematic summary; thus, this review not only aims explore factors contributing HCC, but more importantly, summary methods conquer or mitigate resistance. The results suggest that abnormal activation pathways, transport, epigenetics, tumour microenvironment, cancer stem cells, regulated cell death, epithelial-mesenchymal transition, other involved development subsequent progression. To improve therapeutic outcomes inhibiting acquired resistance, combined therapies, nano-delivery carriers may be possible approaches.

Language: Английский

Citations

11
Hyaluronic acid-functionalized graphene-based nanohybrids for targeted breast cancer chemo-photothermal therapy DOI Creative Commons
Rita Lima‐Sousa, Bruna L. Melo, António Mendonça

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 651, P. 123763 - 123763

Published: Jan. 2, 2024

Nanomaterials' application in cancer therapy has been driven by their ability to encapsulate chemotherapeutic drugs as well reach the tumor site. Nevertheless, nanomedicines' translation limited due lack of specificity towards cells. Although nanomaterials' surface can be coated with targeting ligands, such mostly achieved through non-covalent functionalization strategies that are prone premature detachment. Notwithstanding, cells often establish resistance mechanisms impair effect loaded drugs. This bottleneck may addressed using near-infrared (NIR)-light responsive nanomaterials. The NIR-light triggered hyperthermic generated these nanomaterials cause irreversible damage or sensitize them chemotherapeutics' action. Herein, a novel covalently functionalized targeted NIR-absorbing nanomaterial for chemo-photothermal was developed. For such, dopamine-reduced graphene oxide were bonded hyaluronic acid, and then doxorubicin (DOX/HA-DOPA-rGO). produced showed suitable physicochemical properties, high encapsulation efficiency, photothermal capacity. vitro studies revealed cytocompatible display an improved uptake CD44-overexpressing breast Importantly, combination DOX/HA-DOPA-rGO NIR light reduced cells' viability just 23 %, showcasing potential therapy.

Language: Английский

Citations

9