Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

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Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems

Nature Reviews Drug Discovery, Journal Year: 2023, Volume and Issue: 22(5), P. 387 - 409

Published: March 27, 2023

Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education empowerment have proved to be prohibitively complex and/or ineffective. Formulating pharmaceutical drug delivery system (DDS) promising alternative that can directly mitigate many common impediments adherence, including frequent dosing, adverse effects delayed onset of action. Existing DDSs already positively influenced patient acceptability improved rates across various disease types. The next generation systems potential instate an even more radical paradigm shift by, for example, permitting oral biomacromolecules, allowing autonomous dose regulation enabling several doses mimicked single administration. Their success, however, contingent on their ability address problems made unsuccessful past. Improving recognized as one most impactful cost-effective improving general population. Here, Baryakova colleagues assess next-generation discuss impact had different

Language: Английский

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Paraptosis Inducer to Effectively Trigger Immunogenic Cell Death for Metastatic Tumor Immunotherapy with IDO Inhibition

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 9972 - 9986

Published: May 18, 2023

Paraptosis is characterized by the extensive vacuolization of endoplasmic reticulum (ER) and mitochondria, which will cause release damage-associated molecular patterns to promote immunogenic cell death (ICD). However, tumor can develop an immunosuppressive microenvironment affect ICD activation for purpose immune escape. Herein, a paraptosis inducer (CMN) constructed amplify effect efficient immunotherapy inhibiting activity indoleamine 2,3-dioxygenase (IDO). Initially, CMN prepared assembly copper ions (Cu2+), morusin (MR), IDO inhibitor (NLG919) through noncovalent interactions. Without need extra drug carriers, possesses very high contents exhibits favorable GSH responsiveness disassembly. Subsequently, released MR trigger ER contributing activating immunotherapy. Moreover, NLG919 would inhibit remodel cytotoxic T cells, leading intensive antitumor immunity. Abundant in vivo studies indicate that superior suppressing proliferations not only primary but also metastatic rechallenged tumors. Such GSH-responsive might provide promising strategy enhance

Language: Английский

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Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

Food Chemistry, Journal Year: 2023, Volume and Issue: 430, P. 137115 - 137115

Published: Aug. 7, 2023

Language: Английский

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Antimicrobial Peptides towards Clinical Application—A Long History to Be Concluded

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4870 - 4870

Published: April 29, 2024

Antimicrobial peptides (AMPs) are molecules with an amphipathic structure that enables them to interact bacterial membranes. This interaction can lead membrane crossing and disruption pore formation, culminating in cell death. They produced naturally various organisms, including humans, animals, plants microorganisms. In higher they part of the innate immune system, where counteract infection by bacteria, fungi, viruses parasites. AMPs also be designed de novo bioinformatic approaches or selected from combinatorial libraries, then chemical recombinant procedures. Since their discovery, have aroused interest as potential antibiotics, although few reached market due stability limits toxicity. Here, we describe development phase a number clinical trials antimicrobial peptides. We provide update on pharmaceutical industry overall view therapeutic market. Modifications peptide structures improve vivo bioavailability described.

Language: Английский

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MACHINE LEARNING IN DRUG DISCOVERY: A CRITICAL REVIEW OF APPLICATIONS AND CHALLENGES

Computer Science & IT Research Journal, Journal Year: 2024, Volume and Issue: 5(4), P. 892 - 902

Published: April 17, 2024

This review critically examines the integration of Machine Learning (ML) in drug discovery, highlighting its applications across target identification, hit lead optimization, and predictive toxicology. Despite ML's potential to revolutionize discovery through enhanced efficiency, accuracy, novel insights, significant challenges persist. These include issues related data quality, model interpretability, into existing workflows, regulatory ethical considerations. The advocates for advancements algorithmic approaches, interdisciplinary collaboration, improved data-sharing practices, evolving frameworks as solutions these challenges. By addressing hurdles leveraging capabilities ML, process can be significantly accelerated, paving way development new therapeutics. calls continued research, dialogue among stakeholders realize transformative ML fully. Keywords: Learning, Drug Discovery, Predictive Toxicology, Data Quality, Interdisciplinary Collaboration.

Language: Английский

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Skin Protection by Carotenoid Pigments

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1431 - 1431

Published: Jan. 24, 2024

Sunlight, despite its benefits, can pose a threat to the skin, which is natural protective barrier. Phototoxicity caused by overexposure, especially ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e., polyphenols, flavonoids, photosynthetic pigments, protect against effects radiation, acting not only as photoprotectors like filters but antioxidant anti-inflammatory remedies, alleviating photodamage skin. Plant-based formulations are gaining popularity an attractive alternative synthetic filters. Over past 20 years, large number studies have been published assess photoprotective products, primarily through their antioxidant, antimutagenic, anti-immunosuppressive activities. This review selects most important data on efficacy selected carotenoid representatives from vivo animal models humans, well vitro experiments performed fibroblast keratinocyte cell lines. Recent research carotenoids associated with lipid nanoparticles, nanoemulsions, liposomes, micelles reviewed. The focus was collecting those nanomaterials that serve improve bioavailability stability antioxidants activity.

Language: Английский

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Metal–organic frameworks in drug delivery: engineering versatile platforms for therapeutic applications

RSC Advances, Journal Year: 2024, Volume and Issue: 14(41), P. 30201 - 30229

Published: Jan. 1, 2024

Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design specific features such surface area pore size, encapsulation within not only improves their stability solubility but also allows controlled release kinetics, which therapeutic efficacy minimizes adverse effects. Furthermore, it discusses challenges potential advantages MOF-based delivery, MOF stability, biocompatibility, scale-up production. With further advancements in synthesis, functionalization techniques, understanding interactions using biological systems, can significant promise expanding medicine improving patient outcomes.

Language: Английский

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An Overview on the Role of Government Initiatives in Nanotechnology Innovation for Sustainable Economic Development and Research Progress

Sustainability, Journal Year: 2025, Volume and Issue: 17(3), P. 1250 - 1250

Published: Feb. 4, 2025

Nanoparticle technology has emerged as a fundamental component across various industries, including electronics, renewable energy, textiles, and medical biotechnology, particularly for targeted drug delivery applications. Commercialization profoundly impacted economic growth, especially in the pharmaceutical electronics industries. Moreover, it improved workforce education training, generating millions of employment prospects associated with nanotechnology development. By 2024, Organisation Economic Co-operation Development anticipates that global market products will attain value United States Dollar (USD) 1 trillion to USD 3 trillion, resulting creation over 2 million new employments globally. The swift progression nanoparticle from 2000 2024 is primarily propelled by substantial industrial investment research development, alongside collaborations academic institutions. National Nanotechnology Initiative (US) significantly contributed these developments, federal funding exceeding 30 billion since its establishment 2001. This catalyzed significant advancements both commercial applications nanotechnology. Patent data highlights this expansion, China establishing itself preeminent nation patents. From steadily raised proportion patents, accounting almost 40% total 2024. US, Japan, Germany, Republic Korea continued be contributors, together advancing frontiers innovation In timeframe, quantity nanotechnology-related patents increased more than 150%, demonstrating growth sector. regulation US managed Food Drug Administration, about healthcare biotechnology As scope uses expanded, there an increasing demand extensive regulations concerning potential long-term environmental health effects. future trajectory nanotechnology, worldwide, hinge on continuous invention, advancement, governmental policy. upholding robust regulatory framework promoting ongoing collaboration between academics industry, complete societal progress can actualized.

Language: Английский

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Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.

Language: Английский

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