mRNA Cancer Vaccines: Construction and Boosting Strategies DOI
Xiaoqing Liu, Pei Huang, Rusen Yang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 19550 - 19580

Published: Oct. 11, 2023

In late 2020, the U.S. Food and Drug Administration (FDA) approved a lipid-based mRNA vaccine for prevention of COVID-19, which has pushed this field to be more closely studied motivated researchers delve deeper into therapeutics. To date, research on cancer vaccines been developed rapidly, substantial hopeful therapeutic results have achieved against various solid tumors in clinical trials. review, we first introduce three main components vaccines, including antigens, adjuvants, delivery vectors. Engineering these can optimize effects vaccines. For instance, appropriate modification structure alleviate poor stability innate immunogenicity mRNA, use vectors address issues low efficiency vivo. Second, emphatically discuss some strategies further improve efficacy namely modulating immunosuppressive tumor environment, optimizing administration routes, achieving targeting intended tissues or organs, employing combination therapy. These strengthen inhibitory ability increase possibility elimination. Finally, point out challenges practice offer our perspectives future developments rapidly evolving field. It is anticipated that will therapy near future.

Language: Английский

Multifunctional nanoparticle-mediated combining therapy for human diseases DOI Creative Commons
Xiaotong Li,

Xiuju Peng,

Makhloufi Zoulikha

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Language: Английский

Citations

125
Stimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironments DOI
Tao Sun, Chen Jiang

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114773 - 114773

Published: March 9, 2023

Language: Английский

Citations

75
Agriculture and environmental management through nanotechnology: Eco-friendly nanomaterial synthesis for soil-plant systems, food safety, and sustainability DOI
Abdul Wahab, Murad Muhammad, Shahid Ullah

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171862 - 171862

Published: March 23, 2024

Language: Английский

Citations

64
Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke DOI Creative Commons
Hongyuan Zhang, Zhiqiang Zhao, Shengnan Sun

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 17, 2023

Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death worldwide. However, current drug therapeutics compromised by narrow therapeutic windows, unsatisfactory thrombolysis effects, severe bleeding events, high recurrence rates. In this study, we exploit a self-propelling nano-penetrator with fuel loading controllable motion features, which is molecularly co-assembled using photothermal photosensitizer (DiR) photothermal-activable NO donor (BNN6). The precisely engineered BNN6-DiR pair shows distinct advantages in terms productivity autonomous under laser irradiation. animal models artery/vein thrombosis acute ischemic stroke, self-fueled enables self-navigated thrombus-homing accumulation, self-propelled clot deep penetration, fluorescence image-guided photothermal/mechanical thrombolysis, NO-mediated prevention stroke salvage. As expected, displayed favorable outcomes without risk compared to clinically available thrombolytic drug. This study offers facile, safe, effective nonpharmaceutical modality towards clinical treatment stroke.

Language: Английский

Citations

62
Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer DOI Creative Commons
Shu Huang, Jun Yuan, Yong Xie

et al.

Cancer Nanotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 25, 2023

Abstract Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows new hopes for bone metastatic PCa patients, while efficacy still unsatisfactory and limited by unique immunosuppressive microenvironment site. Here, we developed a bone-targeted nano-delivery system as nano-regulator to enhance immunotherapy PCa. The nanosystem was assembled via coordination between phytic acid (PA) Fe 3+ form nano-sized metal–organic framework (MOF), through which mitoxantrone (MTO) encapsulated. At cellular level, showed selective cytotoxicity towards RM-1 cells over immune cells, could induce tumor immunogenic cell (ICD) improve immunogenicity tumor. Moreover, able ubiquitination TGFβ receptor (TβR) on promote its degradation, thus serving block functions TGF-β, an abundant cytokine that has systematically effect microenvironment. Upon intravenous injection, nanoparticle pro-longed blood circulation targeting accumulation into site, imposed robust anti-tumor combination αCTLA-4. In addition, destruction significantly alleviated after reduce skeletal-related events. Overall, this work provides biocompatible nanomedicine restore sensitivity enhanced blocking TGF-β signaling pathway.

Language: Английский

Citations

62
Neutrophil Camouflaged Stealth Nanovehicle for Photothermal‐Induced Tumor Immunotherapy by Triggering Pyroptosis DOI Creative Commons

Xuya Yu,

Guozheng Xing,

Shupei Sheng

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(15)

Published: March 26, 2023

Abstract The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing recurrence and metastasis. Inspired by the stealth strategy, stealthy nanovehicle based on neutrophil camouflage developed to achieve immunotherapy triggering pyroptosis. comprises anti‐CD11b‐ IR820‐conjugated bovine serum albumin nanoparticles loaded with decitabine. Camouflaged neutrophils, nanovehicles efficient hitchhiking owing biotropism neutrophils tumors. fluorescent signal molecule, IR820, acts as navigation monitor track nanovehicle. released decitabine upregulates gasdermin E, laser irradiation activates caspase‐3, thereby resulting in pyroptosis, which improves system's adaptive immune response. In triple‐negative breast cancer animal model, it regulates microenvironment effective induces long‐lasting strong memory prevent lung

Language: Английский

Citations

57
Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges DOI Creative Commons

Iman Salahshoori,

Mahdi Golriz,

Marcos A.L. Nobre

et al.

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 395, P. 123888 - 123888

Published: Dec. 27, 2023

Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals' targeted and effective administration. However, the intricate interplay between formulations poses challenges their design optimization. Simulations have emerged as indispensable tools for comprehending these interactions enhancing DDS performance to address this complexity. This comprehensive review explores latest advancements simulation techniques provides detailed analysis. The encompasses various methodologies, including molecular dynamics (MD), Monte Carlo (MC), finite element analysis (FEA), computational fluid (CFD), density functional theory (DFT), machine learning (ML), dissipative particle (DPD). These are critically examined context of research. article presents illustrative case studies involving liposomal, polymer-based, nano-particulate, implantable DDSs, demonstrating influential simulations optimizing systems. Furthermore, addresses advantages limitations It also identifies future directions research development, such integrating multiple techniques, refining validating models greater accuracy, overcoming limitations, exploring applications personalized medicine innovative DDSs. employing like MD, MC, FEA, CFD, DFT, ML, DPD offer crucial insights into behaviour, aiding Despite advantages, rapid cost-effective screening, require validation addressing limitations. Future should focus on models, enhance outcomes. paper underscores contribution emphasizing providing valuable facilitating development optimization ultimately patient As we continue explore impact advancing discovery improving DDSs is expected be profound.

Language: Английский

Citations

52
Nanomaterial surface modification toolkit: Principles, components, recipes, and applications DOI Creative Commons

Sümeyra Vural Kaymaz,

Hediyeh Malekzadsani Nobar,

Hasan Sarıgül

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 322, P. 103035 - 103035

Published: Nov. 3, 2023

Surface-functionalized nanostructures are at the forefront of biotechnology, providing new opportunities for biosensors, drug delivery, therapy, and bioimaging applications. The modification significantly impacts performance success various applications by enabling selective precise targeting. This review elucidates widely practiced surface strategies, including click chemistry, cross-coupling, silanization, aldehyde linkers, active ester maleimide epoxy other protein DNA-based methodologies. We also delve into application-focused landscape nano-bio interface, emphasizing four key domains: therapeutics, biosensing, environmental monitoring, point-of-care technologies, highlighting prominent studies. insights presented herein pave way further innovations intersection nanotechnology a useful handbook beginners professionals. draws on sources, latest research articles (2018-2023), to provide comprehensive overview field.

Language: Английский

Citations

44
Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases DOI

Qianqian Huang,

Yongke Chen,

Weiwei Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 519 - 534

Published: Jan. 11, 2024

Language: Английский

Citations

44
Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease DOI Creative Commons

Qianqian Huang,

Chaoqing Jiang,

Xue Xia

et al.

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical hallmarks of Alzheimer’s disease (AD). The intricate pathogenesis causes severe impairment neurons, which, turn, exacerbates Aβ aggregation facilitates AD progression. Herein, multifunctional melanin-like ion chelators neuroinflammation regulators (named PDA@K) were constructed for targeted treatment AD. In this platform, intrinsically bioactive material polydopamine nanoparticles (PDA) potent chelating ROS scavenging effects decorated the KLVFF peptide, endowing system capacity enhanced pathological blood–brain barrier (BBB) crossing lesion site accumulation via hitchhiking. vitro vivo experiment revealed that PDA@K had high affinity toward able to hitch a ride on achieve increased BBB crossing. engineered effectively mitigated aggregate alleviated neuroinflammation. modulated inflammatory microenvironment by promoted microglial polarization M2-like phenotype, which restored their functions neuron care plaque removal. After 3-week PDA@K, spatial learning memory deficit as well neurologic changes FAD 4T transgenic mice largely rescued. Transcriptomics analysis further therapeutic mechanism PDA@K. Our study provided an appealing paradigm directly utilizing intrinsic properties nanomaterials therapeutics instead just using them nanocarriers, widen application therapy.

Language: Английский

Citations

42