Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 25, 2023
Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.
Language: Английский
Citations
629
Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(6), P. 2659 - 2673
Published: March 31, 2022
Abstract The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange compounds between the blood and parenchyma. Moreover, BBB prevents unwanted toxins pathogens from entering brain. This barrier, however, breaks down with age further disruption a hallmark many age-related disorders. Several drugs have been explored, thus far, to protect or restore function. With recent connection gut microbiota, microbial-derived metabolites explored their capabilities physiology. review, will focus on components that make up BBB, dissect levels discuss current therapeutics maintain integrity discoveries effects
Language: Английский
Citations
391
Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(5), P. 3229 - 3237
Published: Jan. 26, 2023
Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout brain spinal cord. It regulates various actions consciousness linked to a variety of neurological diseases. A "hunting-shooting" strategy was proposed this work improve specificity response rate an NE fluorescent probe: 2-(cyclohex-2-en-1-ylidene)malononitrile derivatives were chosen as fluorophore. To create dual-site probe, aldehyde group added ortho ester (or benzene sulfonate). Because its excellent electrophilic activity, could rapidly "hunt" amino then form intramolecular five-membered ring via nucleophilic reaction with β-hydroxyl group. The -NH- "shoots" adjacent group, releasing fluorophore allowing for rapid specific detection. release reuptake ″emetic″-″swallow″ transient process captured visualized under action primary receptor drug. Furthermore, by introducing halogen into lengthen absorption wavelength, lipid solubility, adjust pKa appropriately, probe successfully penetrated blood-brain barrier (BBB). In situ synchronous imaging used detect level brains epileptic normal mice, abnormal expression discovered during epilepsy. Brain anatomy examine distribution changes regions before after This research provides useful tools theoretical foundation diagnosing treating central nervous system diseases early.
Language: Английский
Citations
85
Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 475 - 496
Published: Sept. 9, 2023
In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various functions. This comprehensive review delves into examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical biochemical properties ECMs. We discuss potential integration these ECM-mimics range physiological pathological vitro models, enhancing our understanding behavior organization. Lastly, we propose future research directions for context engineering organ-on-a-chip applications, offering advancements therapeutic approaches improved patient outcomes.
Language: Английский
Citations
60
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114816 - 114816
Published: March 30, 2023
The blood-brain barrier (BBB) prevents efficient drug delivery to the central nervous system. As a result, brain diseases remain one of greatest unmet medical needs. Understanding tridimensional structure BBB helps gain insight into pathology and contributes development novel therapies for diseases. Therefore, 3D models with an ever-growing sophisticated complexity are being developed closely mimic human neurovascular unit. Among these models, hydrogel-, spheroid- organoid-based static have been developed, so microfluidic-based BBB-on-a-chip models. different preclinical BBB, both in health disease, here reviewed, from their application permeability testing nanomedicines across discussing advantages disadvantages each model. validation data vivo is also discussed those cases where provided.
Language: Английский
Citations
51
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 612 - 612
Published: May 10, 2024
Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug delivery to brain. While BBB serves as crucial protective barrier, it poses challenges delivering therapeutic agents their intended targets within brain parenchyma. To enhance for treatment of neurological diseases, several technologies circumvent have been developed last few years. Among them, nanoparticles (NPs) are one most versatile and promising tools. Here, we summarize characteristics NPs that facilitate penetration, including size, shape, chemical composition, surface charge, importantly, conjugation with various biological or synthetic molecules such glucose, transferrin, insulin, polyethylene glycol, peptides, aptamers. Additionally, discuss coating surfactants. A comprehensive overview common vitro vivo models NP penetration studies is also provided. The discussion extends discussing impairment under pathological conditions leveraging alterations delivery. Emphasizing need future uncover inherent properties NPs, review advocates role beyond systems calls efforts translating clinic therapeutics. Overall, stand out highly strategy precise targeting disorders.
Language: Английский
Citations
23
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114494 - 114494
Published: Jan. 5, 2025
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12699 - 12699
Published: Aug. 11, 2023
The blood-brain barrier, which is formed by tightly interconnected microvascular endothelial cells, separates the brain from peripheral circulation. Together with other central nervous system-resident cell types, including pericytes and astrocytes, barrier forms neurovascular unit. Upon neuroinflammation, this becomes leaky, allowing molecules cells to enter potentially harm tissue of system. Despite significance animal models in research, they may not always adequately reflect human pathophysiology. Therefore, are needed. This review will provide an overview terms both health disease. It describe all key elements vitro explore how different compositions can be utilized effectively model a variety neuroinflammatory conditions. Furthermore, it existing types that used basic research study respective pathologies thus far.
Language: Английский
Citations
30
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(4), P. 797 - 797
Published: April 6, 2022
Drug nanocrystals, which are comprised of active pharmaceutical ingredients and only a small amount essential stabilizers, have the ability to improve solubility, dissolution bioavailability poorly water-soluble drugs; in turn, drug nanocrystal technology can be utilized develop novel formulations chemotherapeutic drugs. Compared with passive targeting strategy, tumor-targeted delivery, typically enabled by specific ligands or molecules modified onto surface nanomedicines, circumvents weak heterogeneous enhanced permeability retention (EPR) effect human tumors overcomes disadvantages nonspecific distribution, high administration dosage undesired side effects, thereby contributing improving efficacy safety conventional nanomedicines for chemotherapy. Continuous efforts been made development nanocrystals delivery systems recent years, most encouraging also enlightening further investigation clinical translation.
Language: Английский
Citations
37
Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 225, P. 115100 - 115100
Published: Jan. 25, 2023
Language: Английский
Citations
22