Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(11), P. 109562 - 109562
Published: Jan. 26, 2024
Language: Английский
Cancers, Journal Year: 2023, Volume and Issue: 15(8), P. 2256 - 2256
Published: April 12, 2023
Cancer is one of the most prevalent diseases globally and second major cause death in United States. Despite continuous efforts to understand tumor mechanisms various approaches taken for treatment over decades, no significant improvements have been observed cancer therapy. Lack specificity, dose-related toxicity, low bioavailability, lack stability chemotherapeutics are hindrances treatment. Nanomedicine has drawn attention many researchers due its potential tumor-specific delivery while minimizing unwanted side effects. The application these nanoparticles not limited just therapeutic uses; some them shown extremely promising diagnostic potential. In this review, we describe compare types their role advancing We further highlight nanoformulations currently approved therapy as well under different phases clinical trials. Finally, discuss prospect nanomedicine management.
Language: Английский
Citations
65
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114392 - 114392
Published: Feb. 15, 2023
Prostate cancer is among most malignant tumors around the world and this urological tumor can be developed as result of genomic mutations their accumulation during progression towards advanced stage. Due to lack specific symptoms in early stages prostate cancer, patients are diagnosed that cells display low response chemotherapy. Furthermore, enhance aggressiveness cells. Docetaxel paclitaxel suggested well-known compounds for chemotherapy they possess a similar function therapy based on inhibiting depolymerization microtubules, impairing balance microtubules subsequent delay cell cycle progression. The aim current review highlight mechanisms docetaxel resistance cancer. When oncogenic factors such CD133 upregulation PTEN tumor-suppressor shows decrease expression, malignancy enhances induce drug resistance. phytochemicals anti-tumor have been utilized suppressing chemoresistance Naringenin lovastatin used enhancing sensitivity. Moreover, nanostructures polymeric micelles nanobubbles delivery decreasing risk development. These subjects highlighted provide new insight reversing
Language: Английский
Citations
59
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: July 24, 2023
Abstract The stimuli-responsive nanofibers prepared by electrospinning have become an ideal material due to their large specific surface area and porosity, which can respond extremely quickly external environmental incitement. As intelligent drug delivery platform, efficiently load drugs then be stimulated conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) achieve slow, on-demand targeted release, showing great potential in areas such as delivery, tumor therapy, wound dressing, tissue engineering. Therefore, this paper reviews the recent trends of electrospun platforms field biomedicine.
Language: Английский
Citations
58
Polymers, Journal Year: 2023, Volume and Issue: 15(3), P. 526 - 526
Published: Jan. 19, 2023
Public health, production and preservation of food, development environmentally friendly (cosmeto-)textiles plastics, synthesis processes using green technology, improvement water quality, among other domains, can be controlled with the help chitosan. It has been demonstrated that this biopolymer exhibits advantageous properties, such as biocompatibility, biodegradability, antimicrobial effect, mucoadhesive film-forming capacity, elicitor plant defenses, coagulant-flocculant ability, synergistic effect adjuvant along substances materials. In part, its versatility is attributed to presence ionizable reactive primary amino groups provide strong chemical interactions small inorganic organic substances, macromolecules, ions, cell membranes/walls. Hence, chitosan used either create new materials or modify properties conventional applied on an industrial scale. Considering relevance strategic topics around world, review integrates recent studies key background information constructed by different researchers designing chitosan-based potential applications in aforementioned concerns.
Language: Английский
Citations
52
European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 193, P. 106688 - 106688
Published: Jan. 1, 2024
The limitations of conventional cancer treatment are driving the emergence and development nanomedicines. Research in liposomal nanomedicine for therapy is rapidly increasing, opening up new horizons treatment. Liposomal nanomedicine, which focuses on targeted drug delivery to improve therapeutic effect while reducing damage normal tissues cells, has great potential field therapy. This review aims clarify advantages systems We describe recent understanding spatiotemporal fate liposomes organism after different routes administration. Meanwhile, various types liposome-based that exert their respective side effects were discussed. Moreover, combination agents with other therapies (such as photodynamic photothermal therapy) demonstrated enhanced tumor-targeting efficiency efficacy. Finally, opportunities challenges faced by liposome nanoformulations entering clinical highlighted.
Language: Английский
Citations
45
Aggregate, Journal Year: 2024, Volume and Issue: 5(4)
Published: March 10, 2024
Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.
Language: Английский
Citations
38
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132579 - 132579
Published: May 23, 2024
Language: Английский
Citations
35
Small, Journal Year: 2024, Volume and Issue: 20(30)
Published: March 7, 2024
Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials
Language: Английский
Citations
32
Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 37, P. 101103 - 101103
Published: Feb. 1, 2024
Language: Английский
Citations
24
International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100265 - 100265
Published: June 26, 2024
Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.
Language: Английский
Citations
18