Sensors International, Journal Year: 2024, Volume and Issue: unknown, P. 100325 - 100325
Published: Dec. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 631, P. 122480 - 122480
Published: Dec. 9, 2022
Three-dimensional (3D) printing is an emerging technology with great potential in pharmaceutical applications, providing innovative solutions for both patients and industry. This offers precise construction of the structure dosage forms can benefit drug product design by versatile release modes to meet clinical needs facilitating patient-centric treatment, such as personalized dosing, accommodate treatment specific disease states or patient populations. Utilization 3D also facilitates digital development manufacturing. Development at early stages commercial scale manufacturing has substantially advanced recent years. In this review, we discuss how accelerates early-stage development, including pre-clinical research phase human studies, late-stage well patients. The advantages, current status, challenges employing large dosing are introduced respectively. considerations efforts regulatory agencies address discussed.
Language: Английский
Citations
89
Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(4), P. 324 - 342
Published: Dec. 21, 2023
Language: Английский
Citations
83
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180
Published: Aug. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Language: Английский
Citations
24
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This study explores the formulation and characterization of poly(vinyl alcohol) (PVA)-based composite hydrogels synthesized through solid-state crosslinking. Comprehensive assessments were conducted on their physicochemical properties, leachables, immunogenicity. Swelling experiments demonstrated that incorporation poly(vinylpyrrolidone) (PVP) enhanced water retention, while chitosan had a minimal effect swelling behavior. Qualitative analysis leachables identified water-soluble components, including dehydrated PVA PVP. Fourier-transform infrared (FTIR) spectroscopy confirmed formation ester bonds indicated increased hydrogen bonding post-crosslinking. Thermal stability was validated by differential scanning calorimetry (DSC) thermogravimetric (TGA), with decomposition observed at 320-330 °C. X-ray diffraction (XRD) revealed crystallinity following Solid-state nuclear magnetic resonance (NMR) further chemical changes consistent results from other techniques. In vitro assays using DC2.4 mouse dendritic cells showed hydrogel extracts inhibited cell proliferation without causing cytotoxicity or triggering significant immune responses. These findings highlight hydrogels' biocompatibility stability, supporting potential for biomedical applications.
Language: Английский
Citations
2
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 237 - 237
Published: Feb. 6, 2024
Microneedle (MN) technology is an optimal choice for the delivery of drugs via transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine and disease diagnostics. The biomedical device that offers many advantages including but not limited to painless experience, being time-effective, real-time sensing. This research implements additive manufacturing (AM) fabricate arrays advanced therapeutic applications. Stereolithography (SLA) was used six designs three aspect ratios. array included conical-shaped 100 needles (10 × 10 needle) in each array. microneedles were characterized using optical scanning electron microscopy evaluate dimensional accuracy. Further, mechanical insertion tests performed analyze strength skin penetration capabilities polymeric MN. MNs higher ratios had deformation characteristics suitable deeper levels beyond stratum corneum. both 0.3 mm 0.4 base diameters displayed consistent force–displacement behavior during skin-equivalent test. establishes guidelines fabricating high-accuracy low-cost 3D printing.
Language: Английский
Citations
15
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(10), P. 2618 - 2627
Published: Jan. 1, 2024
The MTX@HMSN/CS-loaded MN patch exhibited enhanced and sustained anti-inflammatory effects against psoriasis with a continuous release of MTX.
Language: Английский
Citations
13
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: Aug. 13, 2024
Abstract The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as blood-retinal barrier and corneal impermeability. Conventional administration methods often fail sustain therapeutic levels may compromise patient safety compliance. Polysaccharide-based microneedles (PSMNs) have emerged transformative solution for ophthalmic delivery. However, comprehensive review of PSMNs in ophthalmology has not been published date. In this review, we critically examine synergy between polysaccharide chemistry microneedle technology enhancing ocular We provide thorough analysis PSMNs, summarizing design principles, fabrication processes, addressed during fabrication, including improving comfort also describe recent advances performance various both research clinical scenarios. Finally, current regulatory frameworks market barriers that are relevant commercial advancement final perspective on area.
Language: Английский
Citations
10
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131650 - 131650
Published: April 16, 2024
Language: Английский
Citations
9
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101504 - 101504
Published: Jan. 19, 2025
Integrating advanced manufacturing techniques and nanotechnology with cutting-edge materials has driven significant progress in global healthcare. Microneedles, recognized for their minimally invasive approach to transdermal sensing drug delivery, achieve enhanced functionality when combined iontophoresis. Iontophoresis-assisted microneedles have emerged as an innovative solution, enabling real-time biosensing precise delivery within closed-loop systems. These integrated platforms represent a major advancement personalized medicine, allowing dynamic therapeutic adjustments based on continuous feedback. This review highlights the latest developments iontophoresis-assisted biosensing, applications. It delves into mechanisms of iontophoresis, assesses its advantages limitations, explores future directions these transformative technologies.
Language: Английский
Citations
2
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 390 - 390
Published: March 19, 2025
Three-dimensional printing technology is transforming pharmaceutical manufacturing by shifting from conventional mass production to additive manufacturing, with a strong emphasis on personalized medicine. The integration of bioinks and AI-driven optimization further enhancing this innovation, enabling drug precise dosages, tailored drug-release profiles, unique multi-drug combinations that respond individual patient needs. This advancement significantly impacting healthcare accelerating development, encouraging innovative designs, treatment efficacy. Traditional follows one-size-fits-all approach, which often fails meet the specific requirements patients medical conditions. In contrast, 3D printing, coupled bioink formulations, allows for on-demand production, reducing dependency large-scale storage. AI-powered design process refine dosage forms, printability, release mechanisms, ensuring precision efficiency in manufacturing. These advancements have potential lower overall costs while improving adherence medication regimens. review explores potential, challenges, environmental benefits positioning it as key driver next-generation
Language: Английский
Citations
2