Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 656 - 656

Published: Feb. 15, 2023

Skin delivery is an exciting and challenging field. It a promising approach for effective drug due to its ease of administration, handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, many other advantages. The main associated challenge, however, low skin permeability. healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in (both topical transdermal) depend on overcoming challenges with molecule permeation irritation. These limitations can be overcome by employing new approaches such lipid nanosystems. Due their advantages (such easy scaling, cost, remarkable stability) these systems have attracted interest from scientific community. However, successful formulation, several factors including particle size, surface charge, components, etc. understood controlled. This review provided brief overview structure well different pathways nanoparticle penetration. In addition, influencing penetration nanoparticles been highlighted. Applications nanosystems dermal transdermal delivery, regulatory aspects, were critically discussed.

Language: Английский

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Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 638, P. 616 - 628

Published: Jan. 31, 2023

Language: Английский

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Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 24, 2023

Abstract The stimuli-responsive nanofibers prepared by electrospinning have become an ideal material due to their large specific surface area and porosity, which can respond extremely quickly external environmental incitement. As intelligent drug delivery platform, efficiently load drugs then be stimulated conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) achieve slow, on-demand targeted release, showing great potential in areas such as delivery, tumor therapy, wound dressing, tissue engineering. Therefore, this paper reviews the recent trends of electrospun platforms field biomedicine.

Language: Английский

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Delivery of antibacterial agents for wound healing applications using polysaccharide-based scaffolds

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 84, P. 104516 - 104516

Published: April 26, 2023

Language: Английский

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Electrospun fibers with blank surface and inner drug gradient for improving sustained release

Biomaterials Advances, Journal Year: 2023, Volume and Issue: 150, P. 213404 - 213404

Published: March 31, 2023

Language: Английский

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QbD Manoeuvred Niclosamide Laden Polylactic-co-Glycolic Acid Nanoparticles-Impregnated Gelatin Nanofibers for the Management of Oral Carcinoma

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 5, 2025

Language: Английский

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Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106681 - 106681

Published: Feb. 7, 2025

Language: Английский

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Electrospun Core–Sheath Nanofibers with a Cellulose Acetate Coating for the Synergistic Release of Zinc Ion and Drugs

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 21(1), P. 173 - 182

Published: Nov. 22, 2023

Precisely modulating the synergistic release behavior of multiple bioactive substances has emerged as a formidable challenge in recent years. In this work, we successfully prepared core–sheath nanofibers, where thin cellulose acetate (CA) coating enrobed core. Curcumin (Cur) was encapsulated core layer model drug, while zinc oxide (ZnO) nanoparticles were loaded on sheath layer. The fiber exhibited straight cylindrical morphology containing nanoparticles, and distinct nanostructure demonstrated through transmission electron microscopy (TEM). X-ray diffraction (XRD) Fourier transform infrared (FTIR) conducted to study physical state compatibility among CA, Cur, ZnO. Drug data indicated that nanofibers able decelerate rate drug release, thickness increased presence ZnO particles. Most remarkably, these remarkable ability sustain drugs ion (Zn2+), two-day synergistically leading significant increase cell proliferation. This material preparation strategy for controlled two is instructive exploration innovative versatile delivery systems.

Language: Английский

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Preparation of pH-responsive magnetic nanocomposite hydrogels based on k-carrageenan/chitosan/silver nanoparticles: Antibacterial carrier for potential targeted anticancer drug delivery

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 246, P. 125546 - 125546

Published: June 23, 2023

Language: Английский

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Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

Micromachines, Journal Year: 2023, Volume and Issue: 14(1), P. 208 - 208

Published: Jan. 14, 2023

Nanomedicine is a new discipline resulting from the combination of nanotechnology and biomedicine. has contributed to development improved treatments, diagnoses, therapies. In this field, nanoparticles have notable importance due their unique properties characteristics, which are useful in different applications, including tissue engineering, biomarkers, drug delivery systems. Electrospinning versatile technique used produce fibrous mats. The high surface area electrospun mats makes them suitable for applications fields using nanoparticles. Electrospun wound dressing, water-treatment filters, biosensors, nanocomposites, medical implants, protective clothing materials, cosmetics, with nanofibers creates hybrid systems that acquire differ components’ characteristics. By utilizing composed dissimilar polymers, two synergize improve overall performance electrospinning This review summarizes polymeric nanofibers, critically analyzing how improves materials contributes reduction some disadvantages found nanometric devices

Language: Английский

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