Carbohydrate Polymer Technologies and Applications,
Journal Year:
2023,
Volume and Issue:
7, P. 100406 - 100406
Published: Dec. 10, 2023
The
extract
of
Citrus
aurantifolia
peel
has
been
encapsulated
into
alginate-gelatin-based
microbeads
using
an
external
ionotropic
gelation
method
to
apply
antibacterial
wound
dressings.
Such
variables,
like
the
alginate-gelatin
ratio,
quantity,
and
CaCl2
cross-linkers,
were
optimized
produce
a
good
yield,
well-distributed
size,
encapsulation
efficiency.
Antibacterial
efficacy
was
tested
against
both
S.
aureus
E.
coli.
Optimal
microbead
characteristics
obtained
at
alginate:gelatin
concentration
ratio
1.75%:0.25%
(w/v),
with
15
mg
2%
cross-linker.
These
conditions
resulted
in
82.94
±
1.056%
particle
sizes
between
1.080-1.244
µm,
efficiency
79.127
0.186%.
exhibited
almost
spherical
morphology
slightly
rough
surface.
release
mechanism
out
governed
by
diffusion
erosion
shells
following
Korsmeyer-Peppas
kinetic
model
(k=1.014
0.007/min).
Upon
immobilizing
on
gauze,
add-on
percentage
73.98%
observed.
Moreover,
gauze-immobilized
inhibited
coli
growth
inhibition
zones
11±1.48
12.56±4.89
mm,
respectively.
In
conclusion,
have
demonstrated
optimal
effective
coli,
showcasing
their
potential
as
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100823 - 100823
Published: Oct. 1, 2023
Wound
care
and
treatment
can
be
critical
from
a
clinical
standpoint.
While
different
strategies
for
the
management
of
skin
wounds
have
been
developed,
limitations
inherent
in
current
approaches
necessitate
development
more
effective
alternative
strategies.
Advances
tissue
engineering
resulted
novel
promising
accelerating
wound
healing.
The
use
various
biomaterials
capable
regeneration
damaged
is
engineering.
In
this
regard,
cerium
oxide
nanoparticles
(CeO
Biomimetics,
Journal Year:
2023,
Volume and Issue:
8(5), P. 442 - 442
Published: Sept. 20, 2023
The
field
of
regenerative
medicine
is
constantly
advancing
and
aims
to
repair,
regenerate,
or
substitute
impaired
unhealthy
tissues
organs
using
cutting-edge
approaches
such
as
stem
cell-based
therapies,
gene
therapy,
tissue
engineering.
Nevertheless,
incorporating
artificial
intelligence
(AI)
technologies
has
opened
new
doors
for
research
in
this
field.
AI
refers
the
ability
machines
perform
tasks
that
typically
require
human
ways
learning
patterns
data
applying
without
being
explicitly
programmed.
potential
improve
accelerate
various
aspects
development,
particularly,
although
not
exclusively,
when
complex
are
involved.
This
review
paper
provides
an
overview
context
medicine,
discusses
its
applications
with
a
focus
on
personalized
highlights
challenges
opportunities
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 965 - 992
Published: Jan. 1, 2024
Abstract:
Diabetic
wounds
pose
a
significant
challenge
to
public
health,
primarily
due
insufficient
blood
vessel
supply,
bacterial
infection,
excessive
oxidative
stress,
and
impaired
antioxidant
defenses.
The
aforementioned
condition
not
only
places
physical
burden
on
patients'
prognosis,
but
also
amplifies
the
economic
strain
medical
system
in
treating
diabetic
wounds.
Currently,
effectiveness
of
available
treatments
for
is
limited.
However,
there
hope
potential
metal
nanoparticles
(MNPs)
address
these
issues.
MNPs
exhibit
excellent
anti-inflammatory,
antioxidant,
antibacterial
pro-angiogenic
properties,
making
them
promising
solution
In
addition,
stimulate
expression
proteins
that
promote
wound
healing
serve
as
drug
delivery
systems
small-molecule
drugs.
By
combining
with
other
biomaterials
such
hydrogels
chitosan,
novel
dressings
can
be
developed
revolutionize
treatment
present
article
provides
comprehensive
overview
research
progress
utilization
Building
upon
this
foundation,
we
summarize
underlying
mechanisms
involved
discuss
application
delivery.
Furthermore,
provide
an
extensive
analysis
discussion
clinical
implementation
dressings,
while
highlighting
future
prospects
utilizing
management.
conclusion,
represent
strategy
healing.
Future
directions
include
biological
nanomaterials
synthesize
new
or
physicochemical
properties
Synthetic
contain
play
role
all
stages
healing,
stable
physiological
environment
wound-healing
process.
Keywords:
nanoparticles,
wound,
delivery,
activity
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(3), P. 300 - 300
Published: Feb. 21, 2024
Wounds,
which
are
becoming
more
common
as
a
result
of
traumas,
surgery,
burns,
and
chronic
illnesses
like
diabetes,
remain
critical
medical
problem.
Infectious
bacteria
impact
the
healing
process,
particularly
if
its
biofilm
(biological
films)
leads
to
prolonged
effect.
Nanomaterials
have
emerged
promising
candidates
in
field
wound
due
their
unique
properties
versatile
applications.
New
insights
into
interactions
between
nanomaterials
microenvironments
shed
light
on
mechanisms
underlying
therapeutic
effects.
However,
significantly
minimal
amount
research
has
been
carried
out
see
these
promote
process.
In
this
review,
we
provided
an
outline
various
types
that
studied
for
wounds
infection
prevention.
Overall,
utilization
holds
great
promise
continues
evolve,
providing
new
opportunities
development
effective
efficient
care
therapies.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(3), P. 327 - 327
Published: Feb. 26, 2024
Bacterial
infections
are
major
problems
in
wound
care
due
to
their
impact
on
the
retarded
process
of
healing,
leading
chronic
wounds.
Most
presently
utilized
dressing
products
exhibit
poor
antimicrobial
properties.
Wound
dressings
formulated
from
chitosan
have
been
reported
be
effective
for
treating
infected
wounds,
resulting
antibacterial
properties
chitosan.
The
chitosan-based
can
further
enhanced
by
incorporating
metallic
nanoparticles
into
them,
such
as
silver,
zinc,
titanium,
etc.
incorporation
silver
has
widely
explored
design
dressings.
promotes
accelerated
wound-healing
processes
activity.
healing
these
metal-based
is
via
regulation
re-epithelialization
and
inflammation
without
affecting
viability
normal
cells.
However,
there
few
reports
that
evaluate
infectious
animal
models
prove
efficacy.
vivo
toxicity
still
needs
addressed,
revealing
need
preclinical
clinical
trials.
fabrication
incorporated
with
not
fully
explored,
especially
wounds
requiring
immediate
treatment.
possible
interactions
between
scaffolds
result
synergistic
effects
understood
studied.
This
review
provides
a
comprehensive
report
outcomes
materials
loaded
managing
Advanced Industrial and Engineering Polymer Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Bio-based
polymers
have
garnered
significant
interest
across
the
manufacturing
industry,
global
economy,
and
various
engineering
disciplines
such
as
packaging,
tissue
engineering,
controlled
drug
delivery,
wound
dressing,
textiles.
In
current
era,
bio-based
polymers,
notably
polysaccharides,
offer
a
promising
platform
for
constructing
intricate
versatile
structures
in
biomedical
sector.
These
encompass
applications
regenerative
medicine
(TERM),
delivery
devices,
coatings
wearable
sensors,
thanks
to
their
distinctive
features
inherent
biocompatibility,
flexibility,
stretchability,
mechanical
strength,
renewability,
physiological
activity,
favorable
biological
environment.
this
review,
we
concise
overview
of
diverse
types
polysaccharide-based
composites,
properties,
interactions
with
specific
cells
tissues.
The
review
encompasses
recent
progress
scaffolds
designed
cartilage,
skin,
neural,
vascular,
cardiac,
bone
regeneration,
employing
both
conventional
modern
techniques.
Additionally,
it
delves
into
development
other
biodegradable
including
systems
(DDSs),
antibacterial
on
medical
electronic
devices
healthcare
Furthermore,
also
elucidates
research
directions
future
perspectives
while
emphasizing
importance
regulatory
approvals
commitment
environmental
sustainability.
This
well-organized
critical
is
expected
assist
practitioners
researchers
gaining
deeper
understanding
trends,
challenges,
potential
solutions,
thereby
harnessing
immense
biomaterials
system.
utilization
polysaccharides
sector
aligns
principles
nature,
contributing
reduction
carbon
dioxide
emissions
supporting
Sustainable
Development
Goals
United
Nations.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Abstract
Effective
wound
management
and
treatment
are
crucial
in
clinical
practice,
yet
existing
strategies
often
fall
short
fully
addressing
the
complexities
of
skin
healing.
Recent
advancements
tissue
engineering
have
introduced
innovative
approaches,
particularly
through
use
nanobiomaterials,
to
enhance
healing
process.
In
this
context,
titanium
dioxide
nanoparticles
(TiO2
NPs)
garnered
attention
due
their
excellent
biological
properties,
including
antioxidant,
anti-inflammatory,
antimicrobial
properties.
Furthermore,
these
can
be
modified
therapeutic
benefits.
Scaffolds
dressings
containing
TiO2
NPs
demonstrated
promising
outcomes
accelerating
enhancing
regeneration.
This
review
paper
covers
process,
properties
that
make
them
suitable
for
promoting
healing,
methods
synthesizing
NPs,
scaffolds
application
potential
toxicity
NPs.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 27, 2024
Abstract
The
development
of
innovative
wound
dressing
materials
is
crucial
for
effective
care.
It’s
an
active
area
research
driven
by
a
better
understanding
chronic
pathogenesis.
Addressing
care
properly
clinical
challenge,
but
there
growing
demand
advancements
in
this
field.
synergy
medicinal
plants
and
nanotechnology
offers
promising
approach
to
expedite
the
healing
process
both
acute
wounds
facilitating
appropriate
progression
through
various
phases.
Metal
nanoparticles
play
increasingly
pivotal
role
promoting
efficient
preventing
secondary
bacterial
infections.
Their
small
size
high
surface
facilitate
enhanced
biological
interaction
penetration
at
site.
Specifically
designed
topical
drug
delivery,
these
enable
sustained
release
therapeutic
molecules,
such
as
growth
factors
antibiotics.
This
targeted
ensures
optimal
cell-to-cell
interactions,
proliferation,
vascularization,
fostering
controlled
healing.
Nanoscale
scaffolds
have
significant
attention
due
their
attractive
properties,
including
delivery
capacity,
porosity
area.
They
mimic
Extracellular
matrix
(ECM)
hence
biocompatible.
In
response
alarming
rise
antibiotic-resistant,
biohybrid
nanofibrous
dressings
are
gradually
replacing
conventional
antibiotic
systems.
emerging
class
comprises
biopolymeric
nanofibers
with
inherent
antibacterial
nature-derived
compounds,
biofunctional
agents.
Nanotechnology,
diminutive
nanomaterials,
nanoscaffolds,
nanofibers,
biomaterials
harnessed
aimed
review
article
discusses
effects
loaded
on
healing,
(in
vivo
vitro)
mechanical
outcomes.
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