Curcumin nanocrystals-in-nanofibres as a promising platform for the management of periodontal disease

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 648, P. 123585 - 123585

Published: Nov. 10, 2023

It is estimated that nearly a half of the world's population over 30 years old suffer from some kind periodontal disease (PD). Although preventable, PD can pose significant health burden to patients, causing pain and discomfort disfigurement death. The management often requires surgical procedures accompanied systemic antibiotic anti-inflammatory treatments. Curcumin (CUR), potent antimicrobial active, has shown great promise in PD; however, its effects are limited by low bioavailability. In this work, we report development electrospun nanofibres (NFs) loaded with CUR nanocrystals (NCs) for PD. NCs 100 nm were obtained media milling into dissolving polyvinyl alcohol NFs using electrospinning. resultant NCs-in-NFs dissolved water spontaneously, releasing particle size ∼120 nm. physiochemical characterisation systems indicated absence chemical interactions between drug polymer, an amorphous nature. vitro release profiles demonstrated had significantly higher dissolution rate (∼100 % at day 40) than control group (approximately 6 40), which consisted containing physical mixture stabiliser. Finally, mucosal deposition studies 10-fold capacity novel system deposit ex vivo excised neonatal porcine tissue, when compared group.

Language: Английский

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“Nano in Nano”—Incorporation of ZnO Nanoparticles into Cellulose Acetate–Poly(Ethylene Oxide) Composite Nanofibers Using Solution Blow Spinning

Polymers, Journal Year: 2024, Volume and Issue: 16(3), P. 341 - 341

Published: Jan. 26, 2024

In this work, the preparation and characterization of composites from cellulose acetate (CA)–poly(ethylene oxide) (PEO) nanofibers (NFs) with incorporated zinc oxide nanoparticles (ZnO-NPs) using solution blow spinning (SBS) is reported. CA–PEO were produced by that contained a higher CA-to-PEO ratio lower (equal) ratio. Nanoparticles added to comprise 2.5% 5% solution, calculated on weight polymers. To have better control SBS processing conditions, suspensions carried out, which reveals decrease in viscosity (two- eightfold) upon addition NPs. It observed variation does not significantly affect mean diameters nanofibers, but mode nanofibers’ size distribution, whereby provides thinner fibers. FESEM–EDS confirms ZnO NP encapsulation into specifically CA component based UV-vis studies, since release detected for up 5 days deionized water, despite significant swelling material accompanied dissolution water-soluble PEO. Upon acetone, immediate detected, both visually spectrometer. ATR–FTIR studies reveal interaction composite nanofibers. As are known their bioactivity, it can be concluded these CA–PEO–ZnO good candidates used filtration membranes, no loss NPs or an environment.

Language: Английский

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Janus silk fibroin/polycaprolactone-based scaffold with directionally aligned fibers and porous structure for bone regeneration

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129927 - 129927

Published: Feb. 3, 2024

Language: Английский

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Fixation of nanoparticles on fabric: Applications in general health management

Materials Today Communications, Journal Year: 2024, Volume and Issue: 41, P. 110577 - 110577

Published: Oct. 4, 2024

Language: Английский

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Fabrication and Adsorption Characteristics of Cuprammonium Cellulose-Based Membranes for Removing Anionic and Cationic Dyes

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 705, P. 135692 - 135692

Published: Nov. 2, 2024

Language: Английский

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