Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1313 - 1313

Published: April 21, 2023

Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as material of promise for drug delivery biomedical applications. Different chitin chitosan extraction techniques can produce materials with unique properties, which be further modified to enhance their bioactivities. Chitosan-based systems have been developed various routes administration, including oral, ophthalmic, transdermal, nasal, vaginal, allowing targeted sustained release drugs. Additionally, used in numerous applications, such bone regeneration, cartilage tissue cardiac corneal periodontal wound healing. Moreover, also utilized gene delivery, bioimaging, vaccination, cosmeceutical Modified derivatives improve biocompatibility resulting innovative promising potentials This article summarizes the recent findings on its application science.

Language: Английский

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Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 656 - 656

Published: Feb. 15, 2023

Skin delivery is an exciting and challenging field. It a promising approach for effective drug due to its ease of administration, handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, many other advantages. The main associated challenge, however, low skin permeability. healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in (both topical transdermal) depend on overcoming challenges with molecule permeation irritation. These limitations can be overcome by employing new approaches such lipid nanosystems. Due their advantages (such easy scaling, cost, remarkable stability) these systems have attracted interest from scientific community. However, successful formulation, several factors including particle size, surface charge, components, etc. understood controlled. This review provided brief overview structure well different pathways nanoparticle penetration. In addition, influencing penetration nanoparticles been highlighted. Applications nanosystems dermal transdermal delivery, regulatory aspects, were critically discussed.

Language: Английский

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Franz diffusion cell and its implication in skin permeation studies

Journal of Dispersion Science and Technology, Journal Year: 2023, Volume and Issue: 45(5), P. 943 - 956

Published: March 29, 2023

Franz diffusion cell was primarily used to evaluate the permeability and stability of formulations such as topical (gels creams) transdermal (lipid nanoparticle formulations). Diffusion is a straightforward assay that can reliably measure in-vitro ex-vivo drug release from preparations creams, ointments, liposomes formulations, gels. It offered crucial critical perspectives on skin, drug, formulation relationships. In addition, it also employed for toxicity testing quality control. Currently, many medications are available in market, administered through routes. To treat various skin conditions, medical professionals use wide range methods aimed at increasing skin's absorption. The biggest challenge with delivery system determining amount medication penetrating skin. Today, there lot research into creating new dermal dosage forms pharmaceuticals. this review, authors discuss evaluation determine With their strengths weaknesses, these models assessment provide valuable framework investigating dermato-pharmacokinetics different formulations. techniques aid assessing molecules cause irritation by shedding light molecular mechanisms which they penetrate These tools novel strategy medicinal infection disorders. present review explores application, its implication pharmaceutical research, regulation related pharmacopeia.

Language: Английский

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Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4417 - 4441

Published: May 26, 2023

Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use limited by suboptimal bioavailability, serious adverse effects, nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks improve patient compliance, making them promising option (RA). Of course, TDDSs also face unique challenges, as physiological barrier skin makes somewhat limited. To overcome this maximize efficiency, evolved in terms principle facilitation technology, different generations derived, which significantly improved efficiency even achieved individualized controlled delivery. review, we summarize systems, corresponding strategies, applications RA.

Language: Английский

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Smart Skin‐Adhesive Patches: From Design to Biomedical Applications

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(14)

Published: Jan. 22, 2023

Abstract With the advancement of medical and digital technologies, smart skin adhesive patches have emerged as a key player for complex purposes. In particular, with integrated electronics created an excellent platform monitoring health conditions intelligent medication. However, efficient design is still challenging it requires strong combination network structure, adhesion, physical properties, biocompatibility. To assimilated device, one must deep knowledge various patches. This article provides comprehensive review recent advances in skin‐adhesive patches, including hydrogel‐based transdermal electronic (E‐skin) biomedical applications such wound healing, drug delivery, biosensing, monitoring. Furthermore, challenges, implementable strategies, future designs that can potentially provide researchers designing innovative multipurpose are discussed. These advanced approaches promising managing fitness patients who require regular care.

Language: Английский

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E-Tattoos: Toward Functional but Imperceptible Interfacing with Human Skin

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(6), P. 3220 - 3283

Published: March 11, 2024

The human body continuously emits physiological and psychological information from head to toe. Wearable electronics capable of noninvasively accurately digitizing this without compromising user comfort or mobility have the potential revolutionize telemedicine, mobile health, both human–machine human–metaverse interactions. However, state-of-the-art wearable face limitations regarding wearability functionality due mechanical incompatibility between conventional rigid, planar soft, curvy skin surfaces. E-Tattoos, a unique type electronics, are defined by their ultrathin skin-soft characteristics, which enable noninvasive comfortable lamination on surfaces causing obstruction even perception. This review article offers an exhaustive exploration e-tattoos, accounting for materials, structures, manufacturing processes, properties, functionalities, applications, remaining challenges. We begin summarizing properties effects signal transmission across e-tattoo-skin interface. Following is discussion structural designs, manufacturing, attachment processes e-tattoos. classify e-tattoo functionalities into electrical, mechanical, optical, thermal, chemical sensing, as well wound healing other treatments. After discussing energy harvesting storage capabilities, we outline strategies system integration wireless In end, offer personal perspectives challenges future opportunities in field.

Language: Английский

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Transdermal Drug Delivery System: Current Status and Clinical Application of Microneedles

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 801 - 821

Published: Feb. 2, 2024

As a new type of transdermal drug delivery system (TDDS), microneedles have garnered significant attention for their noninvasiveness, portability, controllable administration, and wide-ranging loading capacity. While initially designed administration via the stratum corneum minimizing adverse reactions associated with systemic enhancing patient compliance, recently found applications in multitude medical contexts. Hence, potential transcends mere delivery. Recent reviews on extensively covered various aspects, including needle types, materials, manufacturing methods, as well treating skin diseases. This review aims to provide comprehensive overview diverse designs from different perspectives, which encompass traditional integrated more intelligent structurally optimized ones nowadays. Additionally, this offers analysis material properties utilized applications, nondegradable materials degradable materials. Furthermore, presents these scenarios such regeneration repair, disease treatment, monitoring, prevention. Moreover, discussion article highlights future clinical necessary efforts required achieve widespread adoption. serves valuable reference bridging gap between laboratory setting practice terms using scenarios.

Language: Английский

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Nanotherapeutic approaches for transdermal drug delivery systems and their biomedical applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 207, P. 112819 - 112819

Published: Feb. 6, 2024

Language: Английский

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Dandelion-derived vesicles-laden hydrogel dressings capable of neutralizing Staphylococcus aureus exotoxins for the care of invasive wounds

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 355 - 371

Published: March 6, 2024

Language: Английский

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Advancements in Transdermal Drug Delivery Systems: Harnessing the Potential of Macromolecular Assisted Permeation Enhancement and Novel Techniques

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 9, 2025

Language: Английский

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