Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

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Nanoarchitectonics: the method for everything in materials science

Bulletin of the Chemical Society of Japan, Journal Year: 2023, Volume and Issue: 97(1)

Published: Dec. 1, 2023

Abstract Nanotechnology has revealed the science of nanoscale. The global challenge that will follow is to build functional materials with knowledge nanoscale phenomena. This task carried out by nanoarchitectonics as a postnanotechnology concept. goal material systems architecting atoms, molecules, and nanomaterials building blocks. Fundamentally, all are made atoms molecules. Therefore, nanoarchitectonics, which architects from can be universal way create materials. It may said method for everything in science. From basic units, living cells, complex systems, components nanoarchitectonics. paper presents recent examples research at various size levels, atomic cellular level, specifically, (i) atomistic (ii) molecular (iii) supramolecular (iv) inorganic (v) biomolecular (vi) cell-mimic (vii) cell-based possibility science, an integrative then explored.

Language: Английский

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Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning electrospraying, are facile in manipulate products' shapes. In this review, generated using EHDA for modifying drug release profiles reviewed. These linear nanofibers, round micro‐/nano‐particles, beads‐on‐a‐string hybrids. They can be further divided into different kinds sub‐shapes, explored providing desired pulsatile release, sustained biphasic delayed pH‐sensitive release. Additionally, resulted from organizations electrospun nanofibers discussed delivery, inner structures considered together developing novel delivery systems. future, related shape–performance relationships at nanoscale, besides size, structure structure–performance relationships, would play important roles promoting developments field. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Language: Английский

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Phase-separating Pt(IV)-graft-glycopeptides sequentially sensing pH and redox for deep tumor penetration and targeting chemotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 743 - 756

Published: Jan. 25, 2025

Language: Английский

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Materials Nanoarchitectonics at Dynamic Interfaces: Structure Formation and Functional Manipulation

Materials, Journal Year: 2024, Volume and Issue: 17(1), P. 271 - 271

Published: Jan. 4, 2024

The next step in nanotechnology is to establish a methodology assemble new functional materials based on the knowledge of nanotechnology. This task undertaken by nanoarchitectonics. In nanoarchitectonics, we architect material systems from nanounits such as atoms, molecules, and nanomaterials. terms hierarchy structure harmonization function, created nanoarchitectonics has similar characteristics organization biosystems. Looking at actual biofunctional systems, dynamic properties interfacial environments are key. other words, interfaces important for production bio-like highly systems. this review paper, will be discussed, looking recent typical examples. particular, basic topics “molecular manipulation, arrangement, assembly” “material production” discussed first two sections. Then, following section, “fullerene assembly: zero-dimensional unit advanced materials”, discuss how various structures can very nanounit, fullerene. above examples demonstrate versatile possibilities architectonics interfaces. last these tendencies summarized, future directions discussed.

Language: Английский

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Porphyrin and doxorubicin mediated nanoarchitectonics of copper clusters: a bimodal theranostics for cancer diagnosis and treatment in vitro

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(3), P. 720 - 729

Published: Dec. 24, 2023

Nanoarchitectonics, an emerging strategy, presents a promising alternative for developing highly efficient next-generation functional materials. Multifunctional materials developed using nanoarchitectonics help to mimic biological molecules. Porphyrin-based molecules can be effectively utilized design such assemblies. Metal nanocluster is one of the that shed more insight into nanoarchitectonic Herein, inherently near-infrared (NIR) fluorescing copper (CuC)-mediated structural assembly

Language: Английский

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Materials Nanoarchitectonics: Collaboration between Chem, Nano and Mat

ChemNanoMat, Journal Year: 2023, Volume and Issue: 9(7)

Published: April 4, 2023

Abstract Nanoarchitectonics is the methodology for production of functional materials from nano‐units. In nanoarchitectonics, conversion molecules (chemistry, Chem), control nanostructures (nanotechnology, Nano), and (materials science, Mat) are essential elements. order to explain contribution Chem, Nano, Mat this review article described according two major sections, Chem & Nano Mat. section, integration chemistry nanotechnology overviewed, next Mat, illustrates how nanomaterials architecturally transformed into materials. These include supramolecular polymers metal‐organic frameworks, which have attracted widespread attention, as well emerging areas such organic reactions by nanotechnology, chemical synthesis in nanospace, material creation dynamic motions at interfaces. It emphasized that Chem+Nano+Mat nanoarchitectonics.

Language: Английский

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Bionic nanotheranostic for multimodal imaging-guided NIR-II-photothermal cancer therapy

Nanoscale, Journal Year: 2024, Volume and Issue: 16(12), P. 6095 - 6108

Published: Jan. 1, 2024

In this study, a novel diagnostic-therapeutic integrated nanoplatform (named AMP) was developed for multimodal imaging-guided near-infrared (NIR-II) second window photothermal therapy cancer.

Language: Английский

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Composite Nanoarchitectonics Towards Method for Everything in Materials Science

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(7), P. 2926 - 2947

Published: April 16, 2024

Abstract The characteristic feature of a biofunctional system is that components with various functions work together. These multi-components are not simply mixed together, but rationally arranged. fundamental technologies to do this in an artificial include the synthetic chemistry substances make component unit, science and techniques for assembling them, technology analyzing their nanoostructures. A new concept, nanoarchitectonics, can play role. Nanoarchitectonics post-nanotechnology concept involves building functional materials reflect nanostructures. In particular, approach combining multiple types create composite area where nanoarchitectonics be powerful tool. This review summarizes such examples related studies. presented areas catalyst & photocatalyst, energy, sensing environment, bio medical, other applications illustrate potential wide range applications. order show stages development, only state-of-the-art, also those successful developments existing research. Finally, summary brief discussion future challenges will given. applicable all aims establish ultimate methodology science.

Language: Английский

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Improving Tumor Targeting and Penetration for Nanoparticle‐Mediated Cancer Therapy

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Recent advances in the development of tumor-targeting nanoparticles (NPs) significantly enhance cancer therapies by effectively increasing therapeutic window drugs, improving response tumor cells, and augmenting anti-tumor immunity. However, understanding process remains elusive because complex vivo behavior nanoparticles. Various factors are reported to alter this process; however, systematic studies on mechanisms remain limited. In review, an overview current strategies for targeting their applications chemotherapy immunotherapy, with a focus advancement various barriers effective penetration is provided.

Language: Английский

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