ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 3469 - 3482
Published: April 23, 2024
Bacterial
invasion
hinders
the
healing
process
of
wound,
leading
to
formation
chronic
infected
wound;
meanwhile,
misuse
antibiotics
has
resulted
in
emergence
numerous
drug-resistant
bacteria.
The
application
conventional
antimicrobial
methods
and
wound
treatment
techniques
is
not
appropriate
for
dressings.
In
this
paper,
quaternized
poly(vinyl
alcohol)
(QPVA)
pomegranate-like
copper
uniformly
doped
polydopamine
nanoparticles
(PDA@Cu)
were
introduced
into
a
gelatin-oxidized
carboxymethyl
cellulose
system
form
multicomponent
synergistic
antibacterial
hydrogel
(GOQ
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2487 - 2506
Published: March 1, 2024
Background:
Delayed
wound
healing
in
skin
injuries
has
become
a
significant
problem
clinics,
seriously
affecting
and
even
threatening
life
health.
Recently,
research
interest
increased
developing
dressings
containing
bioactive
compounds
capable
of
improving
outcomes
for
complex
needs.
Methods:
In
this
study,
Puerarin
-loaded
nanoparticles
(Pue-NPs)
were
prepared
using
the
cell-penetrating
peptide-poly
(lactic-co-glycolic
acid)
(CPP-PLGA)
as
drug
carrier
by
emulsified
solvent
evaporation
method.
Then,
they
added
into
poly
(acrylic
to
obtain
self-assembled
nanocomposite
hydrogels
(SANHs)
delivery
system
co-polymerization
The
particle
size,
zeta
potential,
micromorphology
Pue-NPs
measured;
appearance,
mechanical
properties,
adhesive
strength,
biological
activity
SANHs
performed.
Finally,
potential
was
further
evaluated
streptozotocin-induced
diabetic
mice.
Results:
regularly
spherical,
with
an
average
size
134.57
±
1.42
nm
2.14
0.78
mV.
colorless
transparent
honeycomb-like
porous
structure
had
excellent
swelling
ratio
(917%),
water
vapor
transmission
rate
(3077
g·m
−
2
·day
1
),
properties
(Young's
modulus
18
kPa,
elongation
at
break
307%),
strength
(15.5
kPa).
exhibited
sustained
release
Pue
over
48h,
cumulative
55.60
6.01%.
vitro
tests
revealed
that
presented
92.22%
antibacterial
against
Escherichia
coli
after
4h,
61.91%
scavenging
1.1-diphenyl-2-trinitrophenylhydrazine
(DPPH)
radical.
vivo
experiments
showed
accelerated
repair
reducing
inflammatory
response
site,
promoting
angiogenesis,
facilitating
epidermal
regeneration
collagen
deposition.
Conclusion:
conclusion,
we
successfully
SANHs.
Our
results
show
have
performance
improves
mice
model,
indicating
it
can
be
used
develop
effective
strategy
treatment
wounds.
Keywords:
nanoparticles,
hydrogel,
delivery,
Journal of Polymer Science,
Journal Year:
2024,
Volume and Issue:
62(11), P. 2320 - 2339
Published: March 8, 2024
Abstract
Bacterial
infections
are
common
during
skin
wound
healing,
which
can
interrupt
the
healing
process,
delay
and
seriously
affect
quality
of
life.
Long‐term
antibiotic
treatment
may
lead
to
development
drug
resistance.
Traditional
bandages,
sponges,
films,
textiles
commonly
single‐functional,
usually
fail
satisfy
complicated
needs
process.
In
recent
years,
antibacterial
hydrogel
dressings
have
received
extensive
attention
for
infected
chronic
wounds,
serve
as
biocompatible,
multifunctional
platforms
both
promoting
tissue
regeneration
inhibiting
bacterial
infection.
Cationic
polymers
with
inherent
properties
been
used
backbone,
metal
ions
nanoparticles
be
loaded
in
hydrogels
enhance
effects.
Besides,
various
drugs
bioactive
factors
incorporated
provide
anti‐inflammatory
antioxidant
activities
environment
healing.
Additionally,
adhesion
advantages
fixing
at
sites
dressing‐tissue
interactions.
this
review,
we
focus
on
designing
strategies
tissue‐adhesive,
antibacterial,
naturally‐derived
polymer
treating
wounds.
The
typical
mechanisms
summarized.
Finally,
prospects
challenges
further
multi‐functional
treat
wounds
proposed.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 366 - 366
Published: March 13, 2025
Chronic
wounds
pose
a
significant
healthcare
challenge,
impacting
millions
of
patients
worldwide
and
burdening
systems
substantially.
These
often
occur
as
comorbidities
are
prone
to
infections.
Such
infections
hinder
the
healing
process,
complicating
clinical
management
proving
recalcitrant
therapy.
The
environment
within
wound
itself
poses
challenges
such
lack
oxygen,
restricted
blood
flow,
oxidative
stress,
ongoing
inflammation,
bacterial
presence.
Traditional
systemic
treatment
for
chronic
peripheral
may
not
be
effective
due
inadequate
supply,
resulting
in
unintended
side
effects.
Furthermore,
topical
applications
impervious
persistent
biofilm
A
growing
concern
is
therapeutic
modalities
treating
wounds.
Additionally,
chemically
harsh
microenvironment
can
reduce
effectiveness
treatments,
highlighting
need
drug
delivery
that
deliver
therapies
precisely
where
needed
with
optimal
dosages.
Compared
cell-based
therapies,
exosome-based
offer
distinct
advantages
cell-free
approach
treatment.
Exosomes
endosomal
origin
enable
cell-to-cell
communications,
they
possess
benefits,
including
biocompatibility
decreased
immunogenicity,
making
them
ideal
vehicles
efficient
targeting
minimizing
off-target
damage.
However,
exosomes
rapidly
cleared
from
body,
it
difficult
maintain
concentrations
at
sites.
hydrogel-based
development
biocompatible
scaffolds
beneficial
sustained
release
prolong
presence
these
Engineered
have
been
shown
stability
promoting
compared
their
unmodified
counterparts.
Significant
progress
has
made
this
field,
but
further
research
essential
unlock
potential.
This
review
seeks
explore
benefits
opportunities
wounds,
ensuring
efficacy
precise
despite
obstacles
posed
by
environment.
