Polymer‐ and Lipid‐Based Nanostructures Serving Wound Healing Applications: A Review DOI
Fatma Nalan Cetin, Arn Mignon, Sandra Van Vlierberghe

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract Management of hard‐to‐heal wounds often requires specialized care that surpasses the capabilities conventional treatments. Even most advanced commercial products lack functionality to meet needs wounds, especially those complicated by active infection, extreme bleeding, and chronic inflammation. The review explores how supramolecular nanovesicles nanoparticles—such as dendrimers, micelles, polymersomes, lipid‐based nanocarriers—can be key introducing wound healing monitoring properties address complex wounds. Their potential enable functions essential for next‐generation products—such hemostatic functions, transdermal penetration, macrophage polarization, targeted delivery, controlled release pharmaceutical ingredients (antibiotics, gaseous products, anti‐inflammatory drugs, growth factors)—is discussed via an extensive overview recent reports. These studies highlight integration systems in is crucial advancing toward a new generation addressing significant gaps current management practices. Current strategies improvements regarding personalized therapies, promising critically evaluated but underexplored polymer‐based nanovesicles, including polymersomes proteinosomes, healing.

Language: Английский

Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings DOI Creative Commons

A. S. Alberts,

Dana-Ionela Tudorache,

Adelina-Gabriela Niculescu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

Citations

4
Naturally derived hydrogels for wound healing DOI
Duy Toàn Phạm, Nguyễn Thị Thủy, Nguyễn Thị Phương Thảo

et al.

Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 27, 2025

Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity excellent biocompatibility create an ideal moist environment for healing, thereby enhancing cell proliferation tissue regeneration. For this reason, naturally derived formulated from biomaterials such as chitosan, alginate, gelatin, fibroin are highly promising biodegradability low immunogenic responses. Recent integrated approaches utilizing new technologies with bioactive agents significantly improved the mechanical properties of controlled release delivery active compounds, efficiency treatment processes. Herein, review highlights advantages challenges focusing on strength, degradation rates, safety validation, potential incorporating advanced engineering gene therapy utilization personalized medicine.

Language: Английский

Citations

1
A Breakthrough Straightforward Multifunctional Hydrogel Platform Releasing Therapeutic Gas for Advanced Wound Healing DOI Open Access
Dieu Linh Tran,

Quoc-Cuong Tran,

Huyen Thanh Anh Nguyen

et al.

Journal of Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

ABSTRACT The advancement of therapeutic gas treatment has significantly impacted on the biomaterial field, with nitric oxide (NO) gaining attention for its safety, multifunctionality, and role in regulating biological processes. Thus, this study introduces a novel biocatalytic NO‐generating situ forming hydrogel (GTA/Cu) to address wound‐related issues, fabricated through simple, one‐step process by incorporating copper ions (Cu 2+ ) into tannic acid‐conjugated gelatin (GTA). Herein, Cu functions simultaneously as crosslinking agent, catalyst, antibacterial while galloyl groups GTA enable effective tissue adhesion diverse interactions. hydrogels' mechanical properties are controlled varying concentrations (25, 50, 100 mg/mL), higher concentration accelerating gelation enhancing strength. At mg/mL , releases NO up 12 days, reaching cumulative around 200 μM. It also demonstrated robust antioxidant activity, high (~20 kPa), comparable effects Cu‐only samples. Interestingly, released facilitates endothelial cell proliferation, accelerates scratch closure within 36 h, stimulates new tube formation Matrigel, showing VEGF. Additionally, it clearly promotes blood vessel vivo following subcutaneous injection, further highlighting potential practical wound healing applications.

Language: Английский

Citations

0
Thermosensitive-based synergistic antibacterial effects of novel LL37@ZPF-2 loaded poloxamer hydrogel for infected skin wound healing DOI
Zixuan Wang, Yingxiao Sun,

Peijie Dong

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125210 - 125210

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review DOI
Dahlang Tahir,

Syarifuddin Syarifuddin,

E Noor

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

Citations

0
Innovative approaches in bioadhesive design: A comprehensive review of crosslinking methods and mechanical performance DOI

Aftab Yusuf Raj,

Sabrina Sharmin,

Safrin Jannat

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 173, P. 214287 - 214287

Published: March 15, 2025

Language: Английский

Citations

0
Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing DOI Open Access
Tudor Bibire, Alina Diana Panainte, Catalina Natalia Cheaburu-Yılmaz

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3051 - 3051

Published: March 26, 2025

All acute and chronic wound management strategies have limitations. Therefore, there is an urgent need to develop new treatment options for healing. Hydrogels based on natural polymers offer advantages in because they can reduce patients' pain, fight infection, carry targeted drugs speed up the healing process. In this study, we aimed investigate alginate-grafted N-vinylcaprolactam-based matrix a modified release of dexketoprofen (DEX), which potentially useful Free radical polymerization grafted techniques were used prepare thermo-responsive hydrogels. The obtained hydrogels, unloaded hydrogel (HY) dexketoprofen-loaded (DEXHY), characterized analyzed. concentration DEX encapsulated polymer was 4 mg/mL. IC50 values found samples tested by us 607.4 µg/mL HY, 950.4 DEXHY, 2239 DEX. average value cell viability (%) after exposure cells DEXHY 75.4%. exhibited very good vitro closure rate, given its ability modify kinetics. developed study has shown considerable potential facilitate even accelerate healing, including surgical wounds, inhibiting overexpressed inflammation

Language: Английский

Citations

0
Plant Polyphenol‐Based Injectable Hydrogels: Advances and Biomedical Applications DOI Open Access

Renkai Zhang,

Qiuyue Ma,

Nannan Zheng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Plant polyphenol-based hydrogels, known for their biocompatibility and adhesive properties, have emerged as promising materials in biomedical applications. These hydrogels leverage the catechol group's ability to form stable bonds moist environments, similar mussel proteins. This review provides a comprehensive overview of synthesis, adhesion mechanisms, applications, particularly wound healing, tissue regeneration, drug delivery. However, challenges related vivo stability long-term remain critical barriers clinical translation. Future research should focus on enhancing bioactivity, biocompatibility, scalability these while addressing concerns toxicity, immune responses, large-scale manufacturing. Advances artificial intelligence-assisted screening 3D/4D bioprinting are expected accelerate development Furthermore, integration biomimetic designs responsive functionalities, such pH or temperature sensitivity, holds promise further improving therapeutic efficacy. In conclusion, multifunctional plant represents frontier advancing personalized medicine minimally invasive treatments.

Language: Английский

Citations

0
Integration of two-dimensional MXene into polymeric-based nanocomposite hydrogels for various biomedical applications: Recent Advances and Future Prospects DOI Creative Commons
Khurram Shahzad, Muhammad Asim Raza, Abrar Hussain

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113512 - 113512

Published: Oct. 1, 2024

Language: Английский

Citations

3
Composite Polysaccharide Hydrogel Loaded with Scutellaria baicalensis Extract for Diabetic Wound Treatment DOI Creative Commons
Yumeng Zhu,

Fangyan Li,

Shuo Wang

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 605 - 605

Published: Sept. 23, 2024

Diabetic wounds present significant burdens to both patients and the healthcare system due their prolonged inflammatory phase adverse microenvironment. Traditional Chinese medicine (TCM), particularly Scutellaria baicalensis extract (SE), has shown promise in wound healing. Herein, sesbania gum (SG) was oxidized formed hydrogel with carboxymethyl chitosan (CMCS) through imine bond. Then, SE loaded into as a dressing (CMCS−OSG@SE hydrogel). In vitro experiments demonstrated mechanical properties ROS scavenging efficiency of hydrogel, well release its biocompatibility. an vivo study, diabetic mice S. aureus infection were used, CMCS−-OSG@SE accelerated healing by promoting epidermal regeneration collagen deposition. This composite polysaccharide shows great potential for treatment.

Language: Английский

Citations

1