Structural and Property Characterizations of Dual‐Responsive Core–Shell Tecto Dendrimers for Tumor Penetration and Gene Delivery Applications DOI
Junjie Liu, Xiaoyu Wang, Xiaolei Li

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(17)

Published: May 30, 2024

Core-shell tecto dendrimers (CSTDs) with excellent physicochemical properties and good tumor penetration gene transfection efficiency have been demonstrated to the potential replace high-generation in biomedical applications. However, their characterization related biological of CSTDs for enhanced delivery still lack in-depth investigation. Herein, three types dual-responsive are designed thorough investigation efficiency. Three prepared through phenylborate ester bonds phenylboronic acid (PBA)-decorated generation 5 (G5) poly(amidoamine) (PAMAM) as cores monose (galactose, glucose, or mannose)-conjugated G3 PAMAM shells thoroughly characterized via NMR other techniques. It is shown that produced display strong correlation signals between PBA protons, similar hydrodynamic diameters, dual reactive oxygen species- pH-responsivenesses. The proven structure-dependent property terms small interference RNA silencing plasmid DNA editing, thus revealing a great different

Language: Английский

Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy DOI

DaWon Kim,

Kaila Javius-Jones,

Narsimha Mamidi

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(21), P. 10208 - 10220

Published: Jan. 1, 2024

Dendrimers and dendritic NPs are emerging as potential nanoplatforms for cancer immunotherapy. This minireview provides an updated overview of dendrimer conjugates, hybrids, dendron-based copolymers targeted therapy.

Language: Английский

Citations

3
Dendrimers as drug delivery systems for oncotherapy: Current status of promising applications DOI

S. SUEYOSHI,

João Vitor Silva, Felipe Guizze

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 663, P. 124573 - 124573

Published: Aug. 10, 2024

Language: Английский

Citations

3
A polymer nanogel-based therapeutic nanovaccine for prophylaxis and direct treatment of tumors via a full-cycle immunomodulation DOI Creative Commons
Yunqi Guo, Zhiqiang Wang, Gaoming Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 129 - 144

Published: Sept. 23, 2024

Language: Английский

Citations

3
PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding DOI Creative Commons
Olga A. Mostovaya, Igor Shiabiev, Daniil Ovchinnikov

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1379 - 1379

Published: Oct. 27, 2024

Background/Objectives: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, list nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design synthetic building blocks creating universal delivery systems genetic material an unsolved problem. In this work, we propose PAMAM dendrimers with rigid thiacalixarene core in various conformations, i.e., PAMAM-calix-dendrimers, as a platform supramolecular constructor nanomedicine. Results: Third generation macrocyclic three conformations (cone, partial cone, 1,3-alternate) were synthesized first time. obtained capable binding compacting calf thymus DNA, whereby efficiency improved increasing generation, while influence was reduced. A dramatic effect conformation hemolytic activity PAMAM-calix-dendrimers observed. Specifically, notable reduction hemotoxicity associated decrease compound amphiphilicity. Conclusions: We hope results will help reduce financial labor costs developing new drug dendrimers.

Language: Английский

Citations

3
Anti-Tumor Strategies of Photothermal Therapy Combined with Other Therapies Using Nanoplatforms DOI Creative Commons

Rubing Xu,

Shengmei Wang,

Qiuyan Guo

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 306 - 306

Published: Feb. 26, 2025

Conventional cancer treatments often have complications and serious side effects, with limited improvements in 5-year survival quality of life. Photothermal therapy (PTT) employs materials that convert light to heat when exposed near-infrared raise the temperature tumor site directly ablate cells, induce immunogenic cell death, improve microenvironment. This has several benefits, including minimal invasiveness, high efficacy, reduced robust targeting capabilities. Beyond just photothermal conversion materials, nanoplatforms significantly contribute PTT by supplying effective bolstering amplify anti-tumor effects. However, effects alone are ultimately need be combined other therapies. narrative review describes recent progress chemotherapy, radiotherapy, photodynamic therapy, immunotherapy, gene gas chemodynamic photoacoustic imaging, starvation multimodal therapy. Studies shown combining can reduce overcome drug resistance. Despite encouraging results, challenges such as optimizing treatment protocols, addressing heterogeneity, overcoming biological barriers remain. paper highlights potential for personalized, approaches outcomes.

Language: Английский

Citations

0
Hematoporphyrin-Modified Dendrimers Combined Immunoadjuvants for Enhanced Photoimmunotherapy of Colorectal Cancer DOI
Hao Zhong, Jing Liang,

Ximo Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Photoimmunotherapy has emerged as a promising strategy for cancer therapy due to its increased therapeutic effect, ability reverse drug resistance, and enhanced immune activation. But there is still lack of effective nanomaterial-based photothermal (PTT) or photodynamic (PDT) agents in photoimmunotherapy. In this study, photosensitizer hematoporphyrin-modified G5 PAMAM (G5-HP) nanomaterials are synthesized, which exhibit excellent conversion capability effects under 660 nm irradiation, effectively inducing tumor cell ablation immunogenic death (ICD). Besides, ICD induced by G5-HP can generate tumor-associated antigens, thereby enhancing dendritic (DC) maturation subsequent T addition, polymers bind Toll-like receptor (TLR) agonists CpG-ODN through electrostatic interaction, forming stable G5-HP/CpG nanoparticles. The incorporation an immunoadjuvant further amplified DC maturation, synergizing with phototherapy strengthen antitumor immunity. Notably, vivo studies confirmed that nanoparticles significantly suppressed colorectal growth laser while maintaining biocompatibility. Taken together, the synthesized perform PTT PDT efficacy, formed integrate DC-mediated immunotherapy. This study offers treatment, leveraging synergistic immunotherapy achieve superior outcomes.

Language: Английский

Citations

0
Hyperbranched Polymer‐Based Vaccines for Cancer Immunotherapy DOI
Zhiqiang Wang, Yunqi Guo, Mingwu Shen

et al.

Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 23(11)

Published: June 10, 2023

Recently, several immunotherapeutic strategies are extensively studied and entered clinical investigation, suggesting their potential to lead a new generation of cancer therapy. Particularly, vaccine that combines tumor-associated antigens immune adjuvants with nanocarrier holds huge promise for inducing specific antitumor responses. Hyperbranched polymers, such as dendrimers branched polyethylenimine (PEI) possessing abundant positively charged amine groups inherent proton sponge effect ideal carriers antigens. Much effort is devoted design dendrimer/branched PEI-based vaccines. Herein, the recent advances in vaccines immunotherapy reviewed. The future perspectives regard development also briefly discussed.

Language: Английский

Citations

8
Current status and future directions of nanovaccine for cancer: a bibliometric analysis during 2004-2023 DOI Creative Commons

Yuhui Hou,

Yue Li,

Youao Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 29, 2024

Nanovaccine treatment is an exciting area of research in immunology and personalized medicine, holding great promise for enhancing immune responses targeting specific diseases. Their small size allows efficient uptake by cells, leading to robust activation. They can incorporate immune-stimulating molecules boost vaccine efficacy. Therefore, nanovaccine be target tumor-specific antigens, activating the system against cancer cells. Currently, there have been ample evidence showing effectiveness potential as a cancer. However, was rare bibliometric analysis Here we performed visual published studies related cancer, providing trend future development nanovaccine.

Language: Английский

Citations

2
Polydopamine Nanoformulations Induced ICD and M1 Phenotype Macrophage Polarization for Enhanced TNBC Synergistic Photothermal Immunotherapy DOI

Siqi Geng,

Baoru Fang,

Ke Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 59814 - 59832

Published: Oct. 25, 2024

Photothermal therapy (PTT) is a promising technology that can achieve the thermal ablation of tumors and induce immunogenic cell death (ICD). However, relying solely on antitumor immune responses caused by PTT-induced ICD insufficient to suppress tumor metastasis recurrence effectively. Fortunately, multifunctional nanoformulation-based synergistic photothermal immunotherapy eliminate primary metastatic inhibit for long time. Herein, we select polydopamine (PDA) nanoparticles serve as carrier our nanomedicine well potent agent modulator macrophage polarization. PDA are loaded with insoluble adjuvant Imiquimod (R837) construct PDA(R837) nanoformulations. These straightforward yet highly effective nanoformulations demonstrate excellent performance, allowing successful triple-negative breast cancer (TNBC) treatment through immunotherapy. Moreover, experimental results showed implementation PTT in while causing releasing R837, further promoting dendritic (DC) maturation activating systemic response. Furthermore, M1 phenotype polarization, achieving long-term efficacy. Therefore, structurally simple provide have clinical translational application prospects.

Language: Английский

Citations

2
Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy DOI Creative Commons

Sai‐Nan Zhang,

Qibo Huang,

Tuo Ji

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 31, 2024

Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis critical human health, its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities metal ion regulation interact with fate. This review insights into the complex mechanisms metabolism, molecular basis cuproptosis, association cancer development. We assess role cuproptosis-related genes (CRGs) associated tumorigenesis, their importance prognostic indicators targets, impact on tumor microenvironment (TME) immune response. Ultimately, this highlights interplay between copper, immunotherapy.

Language: Английский

Citations

2