Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(12), P. 3208 - 3216
Published: Dec. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.
Language: Английский
Citations
3
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(21), P. 27187 - 27201
Published: May 15, 2024
Development of theranostic nanomedicines to tackle glioma remains be challenging. Here, we present an advanced blood–brain barrier (BBB)-crossing nanovaccine based on cancer cell membrane-camouflaged poly(N-vinylcaprolactam) (PVCL) nanogels (NGs) incorporated with MnO2 and doxorubicin (DOX). We show that the disulfide bond-cross-linked redox-responsive PVCL NGs can functionalized dermorphin imiquimod R837 through membrane functionalization. The formed having a size 220 nm are stable, deplete glutathione, responsively release both Mn2+ DOX under simulated tumor microenvironment exert chemo/chemodynamic therapy mediated by Mn2+, respectively. combined induces immunogenic death maturate dendritic cells (DCs) activate tumor-killing T cells. Further, composed membranes as antigens, adjuvant abilities DC maturation macrophages M1 repolarization, Mn2+-mediated stimulator interferon gene activation effectively act targets immune With dermorphin-mediated BBB crossing, membrane-mediated homologous targeting, Mn2+-facilitated magnetic resonance (MR) imaging property, designed NG-based enables MR combination chemo-, chemodynamic-, imnune orthotopic significantly decreased recurrence rate.
Language: Английский
Citations
7
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 12, 2024
Biomaterials are substances that can be injected, implanted, or applied to the surface of tissues in biomedical applications and have ability interact with biological systems initiate therapeutic responses. Biomaterial-based vaccine delivery possess robust packaging capabilities, enabling sustained localized drug release at target site. Throughout process, they contribute protecting, stabilizing, guiding immunogen while also serving as adjuvants enhance efficacy. In this article, we provide a comprehensive review contributions biomaterials advancement development. We begin by categorizing biomaterial types properties, detailing their reprocessing strategies, exploring several common systems, such polymeric nanoparticles, lipid hydrogels, microneedles. Additionally, investigated how physicochemical properties routes influence immune Notably, delve into design considerations adjuvants, showcasing application development for cancer, acquired immunodeficiency syndrome, influenza, corona virus disease 2019 (COVID-19), tuberculosis, malaria, hepatitis B. review, highlight successful instances where enhanced efficacy discuss limitations future directions immunotherapy. This aims offer researchers understanding stimulate further progress related fields.
Language: Английский
Citations
5
Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102078 - 102078
Published: April 1, 2025
Oncolytic viruses (OVs) combined with radiotherapy (RT) show promise but are limited by challenges such as poor intravenous delivery and insufficient RT-induced DNA damage. In this study, an oncolytic adenovirus (AD) formulation, RadioOnco (AD@PSSP), is developed to improve delivery, infectivity, immune response, RT efficacy. The multifunctional polyethylenimine (PEI)-selenium-polyethylene glycol (PEG) (PSSP) enhances shields the virus from rapid clearance, enables targeted tumor sites after RT. exposed PEI infectivity of AD through electrostatic interactions, thereby increasing damage inhibiting expression repair proteins, CHEK1 CDK1. Furthermore, AD-PEI captures delivers tumor-released antigens lymph nodes, activating robust anti-tumor responses. Animal model data demonstrate that overcomes resistance, targets distant metastases, promotes long-term immunity, addressing metastasis recurrence. summary, intravenously injectable OV synergy surface modification materials.
Language: Английский
Citations
0
Applied Physics Reviews, Journal Year: 2024, Volume and Issue: 11(2)
Published: June 1, 2024
Complex coacervation, a fascinating phenomenon rooted in liquid–liquid phase separation, plays crucial role numerous biological systems. This intricate process involves the segregation of liquid into two distinct phases: coacervate enriched with polymers and polymer-deficient comprising remaining dilute solution. The potential coacervates extends beyond their natural occurrence systems, as they possess capability to encapsulate various types biomolecules an aqueous solution, obviating need for organic solvents. Consequently, considerable efforts have been devoted designing functional nanoscale coacervate-driven assemblies using both synthetic myriad applications. In this review, we provide synthesis discussion formation polymeric driven by complex coacervation. exploration delves fundamental driving forces underpinning elucidates diverse fabrication strategies employed. biomedical applications these are highlighted, focus on roles drug carriers, gene delivery vehicles, antimicrobial agents, theranostic platforms, mucoadhesives, nanoreactors. review aims contribute deeper understanding coacervation-driven assembly systems impact field science technology.
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 25, 2024
The development of nanovaccines capable eliciting tumor-specific immune responses holds significant promise for tumor immunotherapy. However, many nanovaccine designs rely heavily on incorporating multiple adjuvants and carriers, increasing the biological hazards associated with these additional components. Here, this work introduces novel flexible nanocapsules (OVAnano) designed to mimic extracellular vesicles, primarily using ovalbumin antigen minimal polyethylenimine adjuvant These results show that biomimetic structure OVAnano facilitates enhanced uptake by dendritic cells (DCs), leading efficient release into cytosol via endosomal escape, ultimately, successful cross-presentation DCs. Furthermore, modulates intracellular nuclear factor kappa-B (NF-κB) signaling pathway, promoting DC maturation. highly purified antigens in demonstrate remarkable antigen-specific immunogenicity, triggering strong antitumor mediated Therapeutic vaccination studies have also shown administration effectively suppresses growth mice inducing from CD8
Language: Английский
Citations
2
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 95
Published: Jan. 1, 2024
Language: Английский
Citations
0
Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(12), P. 3208 - 3216
Published: Dec. 1, 2024
Language: Английский
Citations
0