Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(17)
Published: May 30, 2024
Core-shell
tecto
dendrimers
(CSTDs)
with
excellent
physicochemical
properties
and
good
tumor
penetration
gene
transfection
efficiency
have
been
demonstrated
to
the
potential
replace
high-generation
in
biomedical
applications.
However,
their
characterization
related
biological
of
CSTDs
for
enhanced
delivery
still
lack
in-depth
investigation.
Herein,
three
types
dual-responsive
are
designed
thorough
investigation
efficiency.
Three
prepared
through
phenylborate
ester
bonds
phenylboronic
acid
(PBA)-decorated
generation
5
(G5)
poly(amidoamine)
(PAMAM)
as
cores
monose
(galactose,
glucose,
or
mannose)-conjugated
G3
PAMAM
shells
thoroughly
characterized
via
NMR
other
techniques.
It
is
shown
that
produced
display
strong
correlation
signals
between
PBA
protons,
similar
hydrodynamic
diameters,
dual
reactive
oxygen
species-
pH-responsivenesses.
The
proven
structure-dependent
property
terms
small
interference
RNA
silencing
plasmid
DNA
editing,
thus
revealing
a
great
different
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Cancer
cells
engage
in
active
aerobic
glycolysis
to
meet
their
bioenergetic
synthesis
needs,
which
is
known
as
the
Warburg
effect.
Such
a
process
leads
lactate
accumulation
tumor
microenvironment
(TME),
further
promoting
cancer
progression
and
inducing
immunosuppression.
Herein,
functionalized
dendrimer‐Cu(II)
complexes
(for
short,
D‐Cu(II))
nanocarrier,
enables
Fenton‐like
reaction
developed
generate
large
amount
of
hydroxyl
radicals
shows
T
1
‐weighted
magnetic
resonance
(MR)
imaging
performance.
Importantly,
D‐Cu(II)
allows
efficient
delivery
oxidase
(LOx)
cells,
directly
downregulating
levels.
When
combining
with
an
immune
activator
leukadherin‐1,
D‐Cu(II)/LOx
alleviate
symptoms
mouse
leukemia.
With
coating
macrophage
membranes,
generated
D‐Cu(II)/LOx@M
for
effective
blood‐brain
barrier
crossing
treat
orthotopic
murine
glioma
model
under
guidance
Cu(II)‐facilitated
MR
imaging.
By
integrating
LOx‐mediated
depletion
Cu(II)‐mediated
chemodynamic
therapy,
dendrimer
nanomedicines
improve
overall
survival
antitumor
responses
mice,
help
remodel
immunosuppressive
TME
both
models,
greatly
sensitizing
treatment
efficacy
activator.
technology
may
be
used
theranostics
other
types
through
depletion‐enhanced
combinational
therapy.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 204 - 204
Published: Jan. 31, 2024
Currently,
biomineralization
is
widely
used
as
a
surface
modification
approach
to
obtain
ideal
material
surfaces
with
complex
hierarchical
nanostructures,
morphologies,
unique
biological
functions,
and
categorized
organizations.
The
fabrication
of
biomineralized
coating
for
the
scaffolds,
especially
synthetic
polymer
can
alter
characteristics,
provide
favorable
microenvironment,
release
various
bioactive
substances,
regulate
cellular
behaviors
osteoblasts,
promote
bone
regeneration
after
implantation.
However,
fabricated
by
immersion
in
simulated
body
fluid
has
disadvantages
non-uniformity,
instability,
limited
capacity
act
an
effective
reservoir
ions
regeneration.
In
this
study,
order
osteoinductivity
3D-printed
PCL
we
optimized
procedure
nano-topographical
guidance.
Compared
constructed
conventional
method,
nano-topographically
guided
possessed
more
mineral
substances
firmly
existed
on
scaffolds.
Additionally,
better
protein
adsorption
ion
capacities.
To
end,
present
work
also
demonstrated
that
scaffolds
USCs,
guide
osteogenic
differentiation
biomimetic
microenvironment
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(17)
Published: May 30, 2024
Core-shell
tecto
dendrimers
(CSTDs)
with
excellent
physicochemical
properties
and
good
tumor
penetration
gene
transfection
efficiency
have
been
demonstrated
to
the
potential
replace
high-generation
in
biomedical
applications.
However,
their
characterization
related
biological
of
CSTDs
for
enhanced
delivery
still
lack
in-depth
investigation.
Herein,
three
types
dual-responsive
are
designed
thorough
investigation
efficiency.
Three
prepared
through
phenylborate
ester
bonds
phenylboronic
acid
(PBA)-decorated
generation
5
(G5)
poly(amidoamine)
(PAMAM)
as
cores
monose
(galactose,
glucose,
or
mannose)-conjugated
G3
PAMAM
shells
thoroughly
characterized
via
NMR
other
techniques.
It
is
shown
that
produced
display
strong
correlation
signals
between
PBA
protons,
similar
hydrodynamic
diameters,
dual
reactive
oxygen
species-
pH-responsivenesses.
The
proven
structure-dependent
property
terms
small
interference
RNA
silencing
plasmid
DNA
editing,
thus
revealing
a
great
different
