Poly(Epsilon-Lysine) Dendrons Inhibit Proliferation in HER2-Overexpressing SKBR3 Breast Cancer Cells at Levels Higher than the Low-Expressing MDA-MB-231 Phenotype and Independently from the Presentation of HER2 Bioligands in Their Structure DOI Open Access
Giordana Peregrino, Laila Kudsiova, Matteo Santin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11987 - 11987

Published: Nov. 8, 2024

Among the known breast cancers, subtype with HER2 receptors-overexpressing cells is associated a poor prognosis. The adopted monoclonal antibody Trastuzumab has improved clinical outcomes, but it drug resistance and relatively high costs. present work peptide solid-phase synthesis method to synthesise branched poly(ε-lysine) dendrons 8 branching arms integrating, at their carboxy terminal molecular root, either an arginine or receptor-binding sequence LSYCCK scramble CSCLYK. These were synthesised in quantities higher than 100 mg/batch purity exceeding 95%. When tested two types of cancer cells, led levels inhibition receptor-overexpressing (SKBR3) comparable low receptor expression (MDA-MB-231) where was more moderate. Noticeably, presence amino acid dendron root did not appear produce any additional inhibitory effect. This demonstrated also when CSCLYK integrated into by lack antiproliferative effect control linear target sequence. specific on proliferation finally proven absence cytotoxicity normal cell migration marker N-Cadherin. Therefore, study shows potential as cost-effective alternative treatment HER2-positive cancer.

Language: Английский

Star-shaped copolypeptide-mediated transfection of 3D organoids DOI

Shiang-Ting Huang,

Yu‐Fon Chen, Yi-Cheng Chen

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113932 - 113932

Published: April 1, 2025

Language: Английский

Citations

0
Advanced hydrogel material for colorectal cancer treatment DOI Creative Commons
Yu Guo,

Min Wang,

Yu‐Zhong Zhang

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 32(1)

Published: Dec. 31, 2024

Colorectal cancer is one of the most common cancers worldwide, and its incidence rates are increasing every year. Treatments for CRC include surgical resection, chemotherapy, radiotherapy, targeted therapy, immunotherapy. Although various agents have been used in treatment malignant tumors, they not as effective expected. This primarily owing to lack selectivity, poor solubility, severe side effects agents. It necessary develop more efficient drug delivery systems precise targeting tumor site therapeutic meet clinical needs. A hydrogel a three-dimensional network material composed crosslinked chains hydrophilic or hydrophobic groups polymer backbone. Hydrogels possess useful properties including high water content, adjustable physical characteristics, elasticity, flexibility, reversible swelling, multifunctionality. These render them ideal biomaterials with broad range applications biomedicine bioengineering. In this review, we introduce pathophysiology current advances summarize hydrogels different materials well smart response carriers treatment. We also analyze unique advantages challenges using therapy.

Language: Английский

Citations

2
New-Generation Drug Delivery Systems (DDSs) in Anticancer Strategies: Impact of Autophagy and Its Modulation DOI
Barbara Canonico, Sabrina Pricl, Sara Biagiotti

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

1
Poly(Epsilon-Lysine) Dendrons Inhibit Proliferation in HER2-Overexpressing SKBR3 Breast Cancer Cells at Levels Higher than the Low-Expressing MDA-MB-231 Phenotype and Independently from the Presentation of HER2 Bioligands in Their Structure DOI Open Access
Giordana Peregrino, Laila Kudsiova, Matteo Santin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11987 - 11987

Published: Nov. 8, 2024

Among the known breast cancers, subtype with HER2 receptors-overexpressing cells is associated a poor prognosis. The adopted monoclonal antibody Trastuzumab has improved clinical outcomes, but it drug resistance and relatively high costs. present work peptide solid-phase synthesis method to synthesise branched poly(ε-lysine) dendrons 8 branching arms integrating, at their carboxy terminal molecular root, either an arginine or receptor-binding sequence LSYCCK scramble CSCLYK. These were synthesised in quantities higher than 100 mg/batch purity exceeding 95%. When tested two types of cancer cells, led levels inhibition receptor-overexpressing (SKBR3) comparable low receptor expression (MDA-MB-231) where was more moderate. Noticeably, presence amino acid dendron root did not appear produce any additional inhibitory effect. This demonstrated also when CSCLYK integrated into by lack antiproliferative effect control linear target sequence. specific on proliferation finally proven absence cytotoxicity normal cell migration marker N-Cadherin. Therefore, study shows potential as cost-effective alternative treatment HER2-positive cancer.

Language: Английский

Citations

0