Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102648 - 102648
Published: Dec. 1, 2024
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151
Published: Oct. 15, 2024
Language: Английский
Citations
22
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 3, 2024
Abstract Electroconductive hydrogels offer a promising avenue for enhancing the repair efficacy of spinal cord injuries (SCI) by restoring disrupted electrical signals along cord’s conduction pathway. Nonetheless, application composed diverse electroconductive materials has demonstrated limited capacity to mitigate post-SCI inflammatory response. Recent research indicated that transplantation M2 microglia effectively fosters SCI recovery attenuating excessive Exosomes (Exos), small vesicles discharged cells carrying similar biological functions their originating cells, present compelling alternative cellular transplantation. This investigation endeavors exploit microglia-derived exosomes (M2-Exos) successfully isolated and reversibly bonded through hydrogen bonding synergistic promotion synergistically enhance repair. In vitro experiments substantiated significant M2-Exos-laden stimulate growth neural stem axons in dorsal root ganglion modulate microglial polarization. Furthermore, M2-Exos remarkable ability initial reaction within injury site. When combined with hydrogel, worked expedite neuronal axonal regeneration, substantially functional rats afflicted SCI. These findings underscore potential as valuable reparative factor, amplifying foster rehabilitation.
Language: Английский
Citations
18
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(16), P. 3807 - 3839
Published: Jan. 1, 2024
This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in case skin cancer therapy. We critically examine significant advancements developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted release, enhanced permeability. These attributes are instrumental addressing limitations inherent traditional treatments represent paradigm shift towards more effective patient-friendly therapeutic approaches. Furthermore, we discuss challenges faced optimizing synthesis process large-scale production while ensuring environmental sustainability. The also emphasizes immense potential clinical applications nanocarriers therapy, highlighting role facilitating targeted, controlled release which minimizes systemic side effects. Future could see being customized to individual patient profiles, potentially revolutionizing personalized medicine oncology. With further research trials, hold promise transforming landscape treatment. this study, aim provide comprehensive overview current state outline future directions advancing development application nanocarriers.
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134591 - 134591
Published: Aug. 8, 2024
Language: Английский
Citations
7
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract With the rapid development of materials science and tissue engineering, a variety biomaterials have been used to construct engineering scaffolds. Due performance limitations single materials, functional composite attracted great attention as tools improve effectiveness biological scaffolds for repair. In recent years, metal-organic frameworks (MOFs) shown promise application in because their high specific surface area, porosity, biocompatibility, appropriate environmental sensitivities other advantages. This review introduces methods construction MOFs-based describes functions mechanisms MOFs repairing damaged tissue. The latest composites applications different tissues are discussed. Finally, challenges future prospects using summarized. aim this is show potential field stimulate further innovation promising area.
Language: Английский
Citations
6
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(4), P. 2022 - 2040
Published: March 20, 2024
Chirality, one of the most fundamental properties natural molecules, plays a significant role in biochemical reactions. Nanomaterials with chiral characteristics have superior properties, such as catalytic optoelectronic and photothermal which potential for specific applications nanomedicine. Biomolecular modifications nucleic acids, peptides, proteins, polysaccharides are sources chirality nanomaterials great application addition to intrinsic chirality, artificial macromolecules, metals. Two-dimensional (2D) nanomaterials, opposed other dimensions, due proper surface area, extensive modification sites, drug loading potential, simplicity preparation, prepared utilized diagnostic applications, delivery research, tumor therapy. Current advanced studies on 2D biomedicine focused novel development, structural control, materials sustainability applications. However, despite advances biomedical still confront challenges difficulty synthesis, quality batch stability, recognition selectivity. This review aims provide comprehensive overview origins, biomolecules cargo highlight their roles biomedicine.
Language: Английский
Citations
6
Applied Materials Today, Journal Year: 2025, Volume and Issue: 42, P. 102616 - 102616
Published: Jan. 31, 2025
Language: Английский
Citations
0
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review explores the synergistic potential of MOF-based MNs and details strategies for integrating MOFs various guest molecules within into to enhance transdermal therapeutic applications.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 8, 2025
Spinal cord injury (SCI), characterized by the disruption of neural pathways and an increase in inflammatory cell infiltration, leads to profound lasting neurological deficits, with a high risk resulting permanent disability. Currently, therapeutic landscape for SCI is notably sparse, limited effective treatment options available. Methylprednisolone (MP), widely used clinical anti-inflammatory agent SCI, requires administration doses that are associated significant adverse effects. In this study, we introduce innovative approach substituting cholesterol MP engineer novel Lipid Nanoparticle (MP-LNP). This strategy aims enhance localization concentration at site, thereby amplifying its efficacy while mitigating systemic side Furthermore, explore integration C3 transferase mRNA into MP-LNPs. transferase, potent inhibitor RhoA pathway, has shown promise facilitating recovery animal models currently being evaluated trials. The formulation, MP-LNP-C3, designed direct site during decompression surgery, offering targeted modality SCI. Our findings reveal several advantages approach: Firstly, incorporation MP-LNPs does not compromise structural integrity nanoparticles, ensuring efficient expression within spinal cord. Secondly, MP-LNP formulation effectively attenuates inflammation reduces effects high-dose acute phase Lastly, MP-LNP-C3 demonstrates notable neuroprotective properties promotes enhanced motor function mouse models. Together, these results underscore potential LNP-based therapy as promising avenue advancing
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 539 - 562
Published: Feb. 13, 2025
Language: Английский
Citations
0