Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
An
intercellular
lipid-cored,
hectorite
nanoplatelet-armored
Pickering
emulsion
system
is
proposed
to
enhance
dermal
penetration
and
moisture
retention.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
European Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
206, P. 107021 - 107021
Published: Jan. 18, 2025
The
main
purpose
of
this
study
was
to
optimize
a
cyclodextrin-based
nanogel
flurbiprofen
(FP)
for
prolonged
dermal
administration
and
evaluate
its
stability,
in
vitro
release,
ex
vivo
skin
permeation,
pharmacokinetic
profile.
nanogels
were
prepared
via
emulsification/solvent
evaporation
process
optimized
through
design
experiments.
Optimal
formulation
characterized
particle
size
(PS),
polydispersity
index
(PDI),
zeta
potential
(ZP),
differential
scanning
calorimetry
(DSC)
X-ray
powder
diffraction
(XRPD),
solubility,
release/ex
permeation
studies
mathematical
modeling,
conducted
rats.
Results
compared
HPMC-based
gel
that
not
nano-sized
(i.e.FP-HPMC
gel).
PS,
PDI
ZP
values
optimal
FP-loaded
295.5
nm,
0.361
-31.9
mV,
respectively
it
stable
12
months.
In
release
studies,
the
flux
from
(96.3
µg/hcm2)
three
times
slower
(i.e.more
controlled)
than
FP-HPMC
(287
µg/hcm2);
permeability
coefficient
(0.015
cm/h)
slightly
less
(0.046
cm/h).
Rat
showed
provided
higher
drug
retention
skin,
gel.
Mathematical
modeling
rat
Hixson-Crowell
model
best
fitting
nanogel,
suggesting
surface
area
is
changing
during
process.
FB-loaded
exhibited
flatter
plasma
profile
gel,
consistent
with
skin.
more
sustained
performance
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: May 25, 2025
Sweeping
contact
with
cancer
continues
to
rise
globally,
which
has
led
advanced
research
on
new
treatment
approaches;
nanotechnology
become
crucial
targeted
therapy.
Within
the
intimate
of
nanomaterials,
Au/Ag
nanostructures
have
emerged
as
highly
attractive
because
their
distinctive
desirable
characteristics
and
prospective
roles
in
diagnosis
well
The
developed
revealed
remarkable
biocompatibility,
optically
recursive
alteration,
magnificently
improved
therapeutic
effects
gold
silver
conjunction
each
other.
This
review
addresses
molecular
systemic
aspects
research,
including
impact
genetic
pathways
use
administration
human
organism.
We
explain
some
related
mechanisms
action,
such
photothermal
therapy
(PTT),
photodynamic
(PDT),
drug
delivery
systems
where
they
display
potential
benefits
towards
offering
a
more
approach
fewer
side
effects.
latest
development
shown
that
prospect
real-time
imaging
biomarker
identification,
owing
this
are
being
viewed
tool
for
individualized
treatment.
However,
there
still
limitations:
challenges
scaling
up,
biological
safety,
bringing
it
clinic.
It
is
therefore
incumbent
upon
these
managements
overcome
hurdles
optimize
impact.
As
result,
current
findings
briefly
reviewed,
directions
discussed
support
revolutionary
role
This
study
aims
to
design
microgels
for
controlled
drug
release
via
enzymatically
generated
pH
changes
in
the
presence
of
glucose.
Modern
medicine
is
focused
on
developing
smart
delivery
systems
with
capabilities.
In
response
this
demand,
we
present
synthesis,
characterization,
and
triggered
behavior
based
poly(acrylic
acid)
modified
glucose
oxidase
(GOx)
(p(AA-BIS)-GOx).
TEM
images
revealed
that
sizes
air-dried
p(AA-BIS)-GOx
were
approximately
130
nm.
DLS
measurements
showed
glucose-triggered
microgel
size
upon
addition,
which
depended
buffer
concentration.
Enzymatically
experiments
using
doxorubicin-loaded
immobilized
GOx
demonstrated
strongly
dependent
The
highest
differences
by
5
25
mM
observed
HEPES
at
concentrations
3
9
mM.
Under
these
conditions,
80
52%
DOX
released
glucose,
while
47
28%
interstitial
concentration
a
tumor
ranges
from
∼15
50
Normal
fasting
blood
levels
are
about
5.5
mM,
postprandial
(2
h
after
meal)
should
be
less
than
7.8
obtained
results
highlight
microgel's
potential
enhanced
permeability
retention
(EPR)
effect,
where
elevated
concentrations.