Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

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Toward the Integration of Machine Learning and Molecular Modeling for Designing Drug Delivery Nanocarriers

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract The pioneering work on liposomes in the 1960s and subsequent research controlled drug release systems significantly advances development of nanocarriers (NCs) for delivery. This field is evolved to include a diverse array such as liposomes, polymeric nanoparticles, dendrimers, more, each tailored specific therapeutic applications. Despite significant achievements, clinical translation limited, primarily due low efficiency delivery an incomplete understanding nanocarrier interactions with biological systems. Addressing these challenges requires interdisciplinary collaboration deep nano‐bio interface. To enhance design, scientists employ both physics‐based data‐driven models. Physics‐based models provide detailed insights into chemical reactions at atomic molecular scales, while leverage machine learning analyze large datasets uncover hidden mechanisms. integration presents harmonizing different modeling approaches ensuring model validation generalization across However, this crucial developing effective targeted By integrating enhanced data infrastructure, explainable AI, computational advances, potentials, researchers can develop innovative nanomedicine solutions, ultimately improving outcomes.

Language: Английский

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Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: A review on recent advances and future challenges

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 135072 - 135072

Published: Aug. 25, 2024

Language: Английский

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Enhanced chemo-photothermal therapy using cisplatin-loaded MXene nanosheets conjugated with Z(BTC) for effective HepG2 cancer treatment

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114128 - 114128

Published: Feb. 1, 2025

Language: Английский

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Investigation of Flurbiprofen Pharmacokinetics in Rats Following Dermal Administration of Optimized Cyclodextrin-Based Nanogel

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 206, P. 107021 - 107021

Published: Jan. 18, 2025

The main purpose of this study was to optimize a cyclodextrin-based nanogel flurbiprofen (FP) for prolonged dermal administration and evaluate its stability, in vitro release, ex vivo skin permeation, pharmacokinetic profile. nanogels were prepared via emulsification/solvent evaporation process optimized through design experiments. Optimal formulation characterized particle size (PS), polydispersity index (PDI), zeta potential (ZP), differential scanning calorimetry (DSC) X-ray powder diffraction (XRPD), solubility, release/ex permeation studies mathematical modeling, conducted rats. Results compared HPMC-based gel that not nano-sized (i.e.FP-HPMC gel). PS, PDI ZP values optimal FP-loaded 295.5 nm, 0.361 -31.9 mV, respectively it stable 12 months. In release studies, the flux from (96.3 µg/hcm2) three times slower (i.e.more controlled) than FP-HPMC (287 µg/hcm2); permeability coefficient (0.015 cm/h) slightly less (0.046 cm/h). Rat showed provided higher drug retention skin, gel. Mathematical modeling rat Hixson-Crowell model best fitting nanogel, suggesting surface area is changing during process. FB-loaded exhibited flatter plasma profile gel, consistent with skin. more sustained performance

Language: Английский

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Polysaccharides as submucosal injection materials (SIMs) in endoscopic resection: A comprehensive review

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 355, P. 123360 - 123360

Published: Feb. 5, 2025

Language: Английский

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Golden insights for exploring cancer: delivery, from genes to the human body using bimetallic Au/Ag nanostructures

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 25, 2025

Sweeping contact with cancer continues to rise globally, which has led advanced research on new treatment approaches; nanotechnology become crucial targeted therapy. Within the intimate of nanomaterials, Au/Ag nanostructures have emerged as highly attractive because their distinctive desirable characteristics and prospective roles in diagnosis well The developed revealed remarkable biocompatibility, optically recursive alteration, magnificently improved therapeutic effects gold silver conjunction each other. This review addresses molecular systemic aspects research, including impact genetic pathways use administration human organism. We explain some related mechanisms action, such photothermal therapy (PTT), photodynamic (PDT), drug delivery systems where they display potential benefits towards offering a more approach fewer side effects. latest development shown that prospect real-time imaging biomarker identification, owing this are being viewed tool for individualized treatment. However, there still limitations: challenges scaling up, biological safety, bringing it clinic. It is therefore incumbent upon these managements overcome hurdles optimize impact. As result, current findings briefly reviewed, directions discussed support revolutionary role

Language: Английский

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Enzymatically Triggered Drug Release from Microgels Controlled by Glucose Concentration

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

This study aims to design microgels for controlled drug release via enzymatically generated pH changes in the presence of glucose. Modern medicine is focused on developing smart delivery systems with capabilities. In response this demand, we present synthesis, characterization, and triggered behavior based poly(acrylic acid) modified glucose oxidase (GOx) (p(AA-BIS)-GOx). TEM images revealed that sizes air-dried p(AA-BIS)-GOx were approximately 130 nm. DLS measurements showed glucose-triggered microgel size upon addition, which depended buffer concentration. Enzymatically experiments using doxorubicin-loaded immobilized GOx demonstrated strongly dependent The highest differences by 5 25 mM observed HEPES at concentrations 3 9 mM. Under these conditions, 80 52% DOX released glucose, while 47 28% interstitial concentration a tumor ranges from ∼15 50 Normal fasting blood levels are about 5.5 mM, postprandial (2 h after meal) should be less than 7.8 obtained results highlight microgel's potential enhanced permeability retention (EPR) effect, where elevated concentrations.

Language: Английский

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Cyclodextrin-transition metal complexes emerge as promising tools for modulating peptide function

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126621 - 126621

Published: Dec. 1, 2024

Language: Английский

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Weaving the gates of life: Pioneering a new era in oral gene delivery with metal-organic frameworks

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158522 - 158522

Published: Dec. 10, 2024

Language: Английский

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