ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(20), P. 23397 - 23415
Published: Oct. 12, 2024
Hydrogen
sulfide
(H2S)
is
recognized
as
the
third
gaseous
signaling
molecule
present,
playing
a
crucial
role
in
cellular
processes.
When
designing
nanomaterials,
H2S
not
only
serves
cancer
biomarker
but
also
directly
influences
tumor
cell
proliferation
and
metastasis
by
modulating
its
concentration.
However,
gas
donor
inability
to
actively
accumulate
within
tumors
release
controlled
manner
results
restricted
treatment
efficacy
potential
toxic
side
effects.
Near-infrared
(NIR)
responsive
photothermal
probes
are
characterized
their
rapid
response
time,
high
selectivity,
sensitivity,
noninvasive
attributes.
They
offer
opportunity
for
precise,
real-time,
modulation
of
concentrations
at
both
murine
levels.
The
integration
therapy
with
other
modalities
through
multifunctional
nanocarrier
platforms
shows
promise
enhancing
outcomes
while
minimizing
adverse
development
capable
controllably
properties
considered
essential
yet
challenging
academic
research.
This
Review
critically
assesses
two
primary
approaches
NIR
strategies
involving
H2S:
targeted
utilizing
combining
alternative
modalities.
Additionally,
this
addresses
current
limitations
these
technologies
outlines
future
directions
advancement.
Overall,
aims
provide
insights
guidance
seamless
therapy,
aligning
rigorous
standards
journals.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 10921 - 10927
Published: April 26, 2024
Reactive
oxygen
species
(ROS)-activated
prodrugs
offer
high
tumor
selectivity
due
to
an
abnormal
ROS
level
in
cells.
However,
effective
prodrug
activation
is
still
limited
by
inadequate
endogenous
ROS.
Here,
we
report
a
ROS-activated
nanoparticle
consisting
of
iron-chelating
polyprodrug.
Due
its
nanostructure,
the
can
achieve
accumulation
via
passive
targeting
effect.
Activated
cancer
cells,
thioacetal
linkers
nanoparticles
will
be
broken
release
cinnamaldehyde
and
chlorambucil.
The
former
increase
intracellular
accelerate
drug
release;
latter
induce
apoptosis
Therefore,
realize
self-accelerated
combination
chemotherapy
chemodynamic
therapy.
This
work
provides
strategy
promote
efficiency
delivery,
enhancing
treatment.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(20), P. 23397 - 23415
Published: Oct. 12, 2024
Hydrogen
sulfide
(H2S)
is
recognized
as
the
third
gaseous
signaling
molecule
present,
playing
a
crucial
role
in
cellular
processes.
When
designing
nanomaterials,
H2S
not
only
serves
cancer
biomarker
but
also
directly
influences
tumor
cell
proliferation
and
metastasis
by
modulating
its
concentration.
However,
gas
donor
inability
to
actively
accumulate
within
tumors
release
controlled
manner
results
restricted
treatment
efficacy
potential
toxic
side
effects.
Near-infrared
(NIR)
responsive
photothermal
probes
are
characterized
their
rapid
response
time,
high
selectivity,
sensitivity,
noninvasive
attributes.
They
offer
opportunity
for
precise,
real-time,
modulation
of
concentrations
at
both
murine
levels.
The
integration
therapy
with
other
modalities
through
multifunctional
nanocarrier
platforms
shows
promise
enhancing
outcomes
while
minimizing
adverse
development
capable
controllably
properties
considered
essential
yet
challenging
academic
research.
This
Review
critically
assesses
two
primary
approaches
NIR
strategies
involving
H2S:
targeted
utilizing
combining
alternative
modalities.
Additionally,
this
addresses
current
limitations
these
technologies
outlines
future
directions
advancement.
Overall,
aims
provide
insights
guidance
seamless
therapy,
aligning
rigorous
standards
journals.
