Plant polysaccharides extracted by high pressure: A review on yields, physicochemical, structure properties, and bioactivities

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 129939 - 129939

Published: Feb. 29, 2024

Language: Английский

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Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 345, P. 122574 - 122574

Published: Aug. 6, 2024

Language: Английский

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Polysaccharide-based drug delivery targeted approach for colon cancer treatment: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139177 - 139177

Published: Jan. 1, 2025

Language: Английский

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Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.

Language: Английский

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Polymer hydrogels: Classification and recent advances

Journal of Macromolecular Science Part A, Journal Year: 2024, Volume and Issue: 61(5), P. 265 - 288

Published: March 19, 2024

Hydrogels comprise of a group crosslinked hydrophilic polymeric materials which are capable absorbing and holding large quantities water in their three-dimensional network structure without undergoing dissolution. More importantly, the ability 'smart' hydrogels to respond certain environmental changes e.g. pH, heat, light, magnetic field, biomolecules have set them apart as unique class materials. A combination several such useful properties resulted tremendous progress toward development advanced hydrogel-based materials, is evident from an explosive amount research publications available this area over last few decades. Owing particularly biocompatibility biodegradability, become material prime importance context wide range applications starting simple contact lenses more complex ones tissue repair, drug delivery, sensors, 3D bioprinting, soft robotics agriculture. This review includes i) overview its classifications based on source, structure, crosslinking mechanism stimuli responsiveness, ii) detailed discussion some most works being carried out field years smart that need hour, domain biomedical applications.

Language: Английский

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Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: A review on recent advances and future challenges

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 135072 - 135072

Published: Aug. 25, 2024

Language: Английский

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Nanogels in Biomedical Engineering: Revolutionizing Drug Delivery, Tissue Engineering, and Bioimaging

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(10)

Published: Oct. 1, 2024

ABSTRACT Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining properties hydrogels nanoparticles to create versatile platforms for drug delivery, tissue bioimaging, other applications. These nanoscale hydrogels, typically ranging from 10 1000 nm, possess unique characteristics such as high water content, biocompatibility, ability encapsulate both hydrophilic hydrophobic molecules. The review explores synthesis, structural configurations, stimuli‐responsive nature nanogels, highlighting their adaptability targeted including across challenging barriers like blood–brain barrier. Furthermore, paper delves into applications particularly delivery systems, demonstrating potential revolutionize these fields. Despite promising preclinical results, challenges remain translating technologies clinical practice, issues related stability, scalability, regulatory approval. concludes by discussing future perspectives, emphasizing need further research optimize ultimately aiming enhance efficacy safety settings.

Language: Английский

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Recent advances in targeted drug delivery for the treatment of glioblastoma

Nanoscale, Journal Year: 2024, Volume and Issue: 16(18), P. 8689 - 8707

Published: Jan. 1, 2024

This review has focused on the up-to-date development of targeted drug delivery systems to GBM, with specific emphasis utilization nanorobotic for active targeting.

Language: Английский

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Strategic chemical synthesis and application of nanocarriers responsive to the tumor microenvironment

Nano Today, Journal Year: 2024, Volume and Issue: 58, P. 102421 - 102421

Published: July 31, 2024

Language: Английский

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Glutathione-responsive polypeptide nanogel encapsulates Shikonin for breast cancer therapy

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2025, Volume and Issue: 64, P. 102802 - 102802

Published: Jan. 7, 2025

Language: Английский

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