Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 318 - 336
Published: Oct. 18, 2024
Language: Английский
Drug Development and Industrial Pharmacy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33
Published: Dec. 4, 2024
Recent developments in nanotechnology have regained the hope enabling eradication of lung cancer, while overcoming drawbacks classic therapeutics. Nevertheless, there are still formidable obstacles that hinder translation such platforms from bench into clinic. Herein, we shed light on clinical potential these formulations and discuss their future directions.
Language: Английский
Citations
2
Pharmacogenomics and Personalized Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 193 - 213
Published: May 1, 2024
Abstract: Hepatocellular carcinoma (HCC) is the dominant type of liver cancers and one deadliest health threats globally. The conventional therapeutic options for HCC are hampered by low efficiency intolerable side effects. Gene therapy, however, now offers hope treatment many disorders previously considered incurable, gene therapy beginning to address shortcomings therapies. Herein, we summarize involvement genes in pathogenesis prognosis HCC, with a special focus on dysregulated signaling pathways, involved immune evasion, non-coding RNAs as novel two-edged players, which collectively offer potential targets HCC. opportunities challenges discussed. These include innovative therapies such genome editing cell Moreover, advanced delivery technologies that recruit nanomedicines use highlighted. Finally, suggestions offered improved clinical translation future directions this area endeavor. Keywords: hepatocellular carcinoma, personalized medicine, nanomedicines,
Language: Английский
Citations
2
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 337 - 348
Published: Aug. 23, 2024
Language: Английский
Citations
2
Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1485 - 1485
Published: Nov. 22, 2024
Hedgehog (Hh) signaling is a well-established developmental pathway; it crucial for early embryogenesis, cell differentiation, and damage-driven regeneration. It being increasingly recognized that dysregulated Hh also involved in fibrotic diseases, which are characterized by excessive extracellular matrix deposition compromises tissue architecture function. As in-depth insights into the mechanisms of obtained, its complex involvement fibrosis gradually illuminated. Notably, some Hh-targeted inhibitors currently under exploration preclinical clinical trials as means to prevent progression. In this review, we provide concise overview biological signaling. We summarize latest advances our understanding roles fibrogenesis across liver, kidneys, airways, lungs, well other tissues organs, with an emphasis on both shared features and, more critically, distinct functional variations observed these organs. thus highlight context dependence signaling, discuss current status challenges therapies fibrosis.
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)
Published: Dec. 26, 2024
Hepatic diseases cause serious public health problems worldwide, and there is an urgent need to develop effective therapeutic agents. In recent years, significant progress made in RNA therapy, molecules, such as mRNAs, siRNAs, miRNAs, aptamers, are shown provide advantages the treatment of hepatic diseases. However, drawbacks RNAs, their poor biological stability, easy degradation by nucleases vivo, low bioavailability, concentrations target tissues, significantly limit clinical application RNA-based drugs. Therefore, exploring developing nanoscale delivery platforms for therapeutics immense value. This review focuses on different types therapeutics, summarizing various strengths weaknesses. Finally, current status future prospects systems therapy discussed.
Language: Английский
Citations
1
Biological and Pharmaceutical Bulletin, Journal Year: 2023, Volume and Issue: 46(12), P. 1648 - 1660
Published: Nov. 30, 2023
This review paper summarizes progress that has been made in the new field of "Controlled Intracellular Trafficking." involves development systems for delivering plasmid DNA (pDNA), small interfering RNA (siRNA), mRNA, proteins, their escape from endosomes, mechanism how they enter nucleus, mithochondria and materials subsequently function within a cell. In addition, strategies these to selective tissue after intravenous administration was also intensively investigated not only liver but tumors, lungs, adipose spleen. 2020, mRNA vaccine developed against coronavirus disease 2019 (COVID-19), where ionizable cationic lipids were used as delivery system. Our strategy identify an efficient (iCL) based on lipid library well applications concerning siRNA/mRNA/pDNA is described.
Language: Английский
Citations
1
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2743 - 2770
Published: March 6, 2024
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 666, P. 124662 - 124662
Published: Sept. 4, 2024
Language: Английский
Citations
0
Journal of Clinical and Translational Hepatology, Journal Year: 2024, Volume and Issue: 000(000), P. 000 - 000
Published: Oct. 11, 2024
This review discussed experimental mouse models used in the pre-clinical study of liver fibrosis regression, a pivotal process preventing progression metabolic dysfunction-associated steatohepatitis to irreversible cirrhosis. These provide valuable resource for understanding cellular and molecular processes underlying regression different contexts. The primary focus this is on most commonly with diet- or hepatotoxin-induced fibrosis, but it also touches upon genetic biliary atresia parasite-induced fibrosis. In addition emphasizing
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 318 - 336
Published: Oct. 18, 2024
Language: Английский
Citations
0