Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 16, 2024
Non-small
cell
lung
cancer
(NSCLC)
constitutes
a
significant
proportion
of
cases,
and
despite
advancements
in
treatment
modalities,
radiotherapy
resistance
remains
substantial
hurdle
effective
management.
Exosomes,
which
are
small
vesicles
secreted
by
cells,
have
emerged
as
pivotal
players
intercellular
communication
influence
various
biological
processes,
including
progression
the
response
to
therapy.
This
review
discusses
intricate
role
exosomes
modulation
NSCLC
radiosensitivity.
The
paper
focuses
on
highlights
how
tumor-derived
contribute
radioresistance
enhancing
DNA
repair,
modulating
immune
responses,
altering
tumor
microenvironment.
We
further
explore
potential
mesenchymal
stem
cell-derived
overcome
their
biomarkers
for
predicting
therapeutic
outcomes.
Understanding
mechanisms
affect
can
provide
new
avenues
efficacy
improving
survival
rates
patients
with
NSCLC.
Biological
carriers
have
emerged
as
significant
tools
to
deliver
radionuclides
in
nuclear
medicine,
providing
a
meaningful
perspective
for
tumor
imaging
and
treatment.
Various
radionuclide-labeled
biological
been
developed
meet
the
needs
of
biomedical
applications.
This
review
introduces
principles
radionuclide-mediated
therapy
selected
criteria
them,
well
comprehensive
description
characteristics
functions
representative
including
bacteria,
cells,
viruses,
their
derivatives,
emphasizing
labeled
strategies
combined
with
radionuclides.
Subsequently,
we
in-depth
introduce
application
treatment,
behaviors
vivo
metastasis
treatment
by
radionuclide
therapy,
plus
other
radiation-induced
photodynamic
therapy.
Finally,
challenges
prospects
are
discussed
improve
shortcomings
this
innovative
platform
promote
clinical
transformation
field
medical
imaging.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
24(9)
Published: Aug. 15, 2024
Atherosclerosis
(AS)
is
a
chronic
inflammation
of
blood
vessels,
which
often
has
no
obvious
symptoms
in
the
early
stage
disease,
but
when
atherosclerotic
plaques
are
formed,
they
cause
lumen
blockage,
and
even
plaque
rupture
leads
to
thrombosis,
that
essential
factor
cardiovascular
events,
for
example
myocardial
infarction,
cerebral
renal
atrophy.
Therefore,
it
considerably
significant
recognition
precise
therapy
plaque.
Biomimetic
nanoparticles
(BNPs),
especially
those
coated
with
cell
membranes,
can
retain
biological
function
membranes
or
cells,
led
extensive
research
application
diagnosis
treatment
AS
recent
years.
In
this
review,
we
summarized
roles
various
key
cells
progression,
construction
biomimetic
based
on
these
as
well
their
applications
therapy.
Furthermore,
give
challenge
prospect
AS,
hoping
elevate
quality
possibility
clinical
translation.
Materials,
Journal Year:
2023,
Volume and Issue:
16(24), P. 7550 - 7550
Published: Dec. 7, 2023
"Green"
strategies
to
build
up
novel
organic
nanocarriers
with
bioperformance
are
modern
trends
in
nanotechnology.
In
this
way,
the
valorization
of
bio-wastes
and
use
living
systems
develop
multifunctional
biogenic
(OBNs)
have
revolutionized
nanotechnological
biomedical
fields.
This
paper
is
a
comprehensive
review
related
OBNs
for
bioactives'
delivery,
providing
an
overview
reports
on
past
two
decades.
first
part,
several
classes
bioactive
compounds
their
therapeutic
role
briefly
presented.
A
broad
section
dedicated
main
categories
nanocarriers.
The
major
challenges
regarding
eco-design
fate
suggested
overcome
some
toxicity-related
drawbacks.
Future
directions
opportunities,
finding
"green"
solutions
solving
problems
nanocarriers,
outlined
final
paper.
We
believe
that
through
review,
we
will
capture
attention
readers
open
new
perspectives
solutions/ideas
discovery
more
efficient
ways
developing
bioperformant
transporting
agents.
Exploration,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
The
tumor
microenvironment
is
characterized
by
immunosuppression
and
compromised
intratumoral
perfusion,
which
impairs
the
effectiveness
of
immune
checkpoint
inhibitors
nanomedicines.
A
significant
challenge
role
activated
platelets,
as
they
increase
transfer‐mediated
PD‐L1
expression
from
cells
maintain
integrity
vasculature.
These
platelets
support
growth
stabilizing
vasculature
enabling
evasion,
well
shielding
detection.
To
address
these
platelet‐mediated
negative
antitumor
effects,
we
have
developed
bioengineered
(PTNPs)
with
surface‐anchored
ticagrelor‐loaded
gelatin
nanoparticles.
This
study
utilizes
natural
tendency
to
localize
their
counterparts
into
tumors.
Upon
binding
tumor‐associated
PTNPs
release
ticagrelor
in
response
secreted
matrix
metalloproteinases
platelet,
inhibiting
further
platelet
activation.
reduction
activation
lessens
platelet‐facilitated
diminishes
transferred‐PD‐L1
cancer
thus
enhancing
anti‐PD‐L1
therapy.
Additionally,
this
strategy
weakens
platelets’
contribution
vascular
integrity,
improving
extravasation
chemotherapeutic
efficacy
Our
findings
highlight
crucial
biology
introduce
an
effective
approach
disrupt
tumor‐supporting
activities
enhance
anticancer
treatments
efficacy.
