Microalgae-based drug delivery microspheres for treatment of hyperuricemia with renal injury

Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102607 - 102607

Published: Jan. 5, 2025

Language: Английский

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Solubilization techniques used for poorly water-soluble drugs

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

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A point-of-care, label-free OECT sensor for uric acid detection: validation in human saliva

Electrochimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 145834 - 145834

Published: Feb. 1, 2025

Language: Английский

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Interpretable machine learning framework to predict gout associated with dietary fiber and triglyceride-glucose index

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: May 14, 2024

Abstract Background Gout prediction is essential for the development of individualized prevention and treatment plans. Our objective was to develop an efficient interpretable machine learning (ML) model using SHapley Additive exPlanation (SHAP) link dietary fiber triglyceride-glucose (TyG) index predict gout. Methods Using datasets from National Health Nutrition Examination Survey (NHANES) (2005–2018) population study fiber, TyG used After evaluating performance six ML models selecting Light Gradient Boosting Machine (LGBM) as optimal algorithm, we interpret LGBM predicting gout SHAP reveal decision-making process model. Results An initial survey 70,190 participants conducted, after a gradual exclusion process, 12,645 cases were finally included in study. Selection best performing associated with (Area under ROC curve (AUC): 0.823, 95% confidence interval (CI): 0.798–0.848, Accuracy: 95.3%, Brier score: 0.077). The feature importance values indicated that age most important affecting output, followed by uric acid (UA). showed lower had more pronounced effect on positive model, while higher Conclusion high accuracy, efficiency, robustness Increasing intake lowering are beneficial reducing potential risk

Language: Английский

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Creating machine learning models that interpretably link systemic inflammatory index, sex steroid hormones, and dietary antioxidants to identify gout using the SHAP (SHapley Additive exPlanations) method

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 1, 2024

Background The relationship between systemic inflammatory index (SII), sex steroid hormones, dietary antioxidants (DA), and gout has not been determined. We aim to develop a reliable interpretable machine learning (ML) model that links SII, DA identification. Methods dataset we used study the DA, was from National Health Nutrition Examination Survey (NHANES). Six ML models were developed identify by DA. seven performance discriminative features of each summarized, eXtreme Gradient Boosting (XGBoost) with best overall selected gout. SHapley Additive exPlanation (SHAP) method explain XGBoost its decision-making process. Results An initial survey 20,146 participants resulted in 8,550 being included study. Selecting performing associated (male: AUC: 0.795, 95% CI: 0.746- 0.843, accuracy: 98.7%; female: 0.822, 0.754- 0.883, 99.2%). In male group, SHAP values showed lower feature lutein + zeaxanthin (LZ), vitamin C (VitC), lycopene, zinc, total testosterone (TT), E (VitE), A (VitA), greater positive effect on output. female E2, LZ, TT, selenium had Conclusion demonstrated accuracy, efficiency, robustness identifying associations participants. Decreased TT males decreased E2 females may be gout, increased intake SII reduce potential risk

Language: Английский

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Neutrophil diversity and function in health and disease

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 5, 2024

Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.

Language: Английский

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Mechanism of Reactive Oxygen Species-Guided Immune Responses in Gouty Arthritis and Potential Therapeutic Targets

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 978 - 978

Published: Aug. 9, 2024

Gouty arthritis (GA) is an inflammatory disease caused by monosodium urate (MSU) crystals deposited in the joint tissues causing severe pain. The can recur frequently and tends to form tophus joints. Current therapeutic drugs for acute phase of GA have many side effects limitations, are unable prevent recurrent attacks formation, overall efficacy unsatisfactory. Therefore, we need advance research on microscopic mechanism seek safer more effective through relevant targets block process. shows that pathogenesis closely related NLRP3 inflammation, oxidative stress, MAPK, NET, autophagy, Ferroptosis. However, after synthesizing sorting out above mechanisms, it found presence ROS throughout almost entire spectrum micro-mechanisms gout process, which combines multiple immune responses a large network diagram complex tight connections involved studies shown cell necrosis, pathological signs be effectively suppressed modulating network-related targets. In this article, one hand, investigated generative generation its association with GA. On other explored potential treatment prevention provide reference ideas development highly

Language: Английский

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Microneedle transdermal drug delivery as a candidate for the treatment of gouty arthritis: Material structure, design strategies and prospects

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 20 - 50

Published: Sept. 3, 2024

Language: Английский

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Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 102 - 102

Published: Jan. 14, 2025

The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, specific form arthritis. calls for combined curative and preventive management model. A new development in the approach to gout is that NLRP3-targeted biologic agents, such monoclonal therapies, provide more accurate treatment by blocking pro-inflammatory cytokines. Nanoparticle drug delivery enhances biological availability targets, which may increase therapeutic efficacy decrease general toxicity. again cannot be ignored, mainly keeping up certain modifications diet weight, along with pharmacological therapies reduce uric acid (UA) levels frequency acute attacks. advancement genetic profiling patients biomarker discoveries drives trend towards building individualized medicine care, quickly gaining ground most effective method delivering treatments individual patients, moving away from one-size-fits-all treatments. following paper aims an updated account focus on recent developments, order enhance these approaches, quality life standard treatment.

Language: Английский

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Anti-inflammatory effect of Plantago asiatica crude extract in rat gout arthritis model

Journal of Immunotoxicology, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 2, 2025

Plantago asiatica L., a perennial herb in the family Plantaginaceae, has been shown to impart several pharmacologic activities, including anti-oxidative, anti-inflammatory, and diuretic effects. In study here, anti-gout(y) arthritis (GA) effects of crude extract from P. L. (PAE) were investigated rat GA model. For this, PAE was prepared by ethanol extraction analyzed for phytochemicals RP-HPLC Q-TOF-MS. Thereafter, potential therapeutic rats; Wistar rats (male, 8 wk-of-age) randomly allocated into four groups (n = 9/group) intra-articularly injected with 3 mg monosodium urate (MSU) saline solution establish study, received oral dosings 0.3 colchicine/kg or 1 g PAE/kg (w/w) before after gout established. At fixed times treatments, assessment joint swelling ratios pathological changes joints, as well select cytokine expression blood, done. results showed contained at least 'active' ingredients, plantamajoside, verbascoside, cymaroside being most abundant. comparison control rats, MSU induced space narrowing, ankle swelling, increased levels pro-inflammatory interleukin (IL)-1β, IL-17a, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, reductions anti-inflammatory IL-10 blood. treatment significantly reversed patho- genic narrowing MSU-induced inflammatory factors, general imparted very similar those seen colchicine (COL; known non-steroidal drug clinical GA). Collectively, these findings provide experimental evidence supporting applicability treat gouty arthritis.

Language: Английский

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