Engineering in NIR‐responsive photothermal materials and their application in wound healing administration

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.

Language: Английский

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Advances in the study of polysaccharide-based hydrogel wound dressings

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134

Published: March 1, 2025

Language: Английский

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Modulating Intracellular Autophagy and Macropinocytosis for Increased Neighboring Drug Delivery

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Neighboring effects provided a valuable direction for in-depth penetration of nanoparticles into tumors. However, the uncontrollable drug transcytosis and limited uptake hindered by viscous cancer-associated fibroblasts (CAFs) greatly limit their penetration. Here, we proposed demonstrated that intracellular autophagosomes could carry remaining drugs to neighboring cells, enhanced macropinocytosis played major role in delivery. To enhance autophagosome-based delivery, Ca2+-doped polydopamine was prepared load GLS1 inhibitor CB-839 modified glutamine (839/CG) triggering macropinocytosis-based active cells uptake. After Ca2+-release caused lysosome damage, 839/CG escaped from lysosomes autophagosome maturation. Then, Ca2+-induced endoplasmic reticulum oscillations starvation both increased blocked autophagy flow, causing 839/CG-contained accumulation. Meanwhile, tumor its response mTOR downregulation-induced hunger, "the more you eat, hungrier get". death, were released actively ingested hungry through macropinocytosis. Combined with photothermal effect triggered CAF decrease, repeated above process Also, immunogenic death antigen presentation DCs infiltration T thereby inhibiting growth lung metastasis.

Language: Английский

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Regenerated silk fibroin coating stable liquid metal nanoparticles enhance photothermal antimicrobial activity of hydrogel for wound infection repair

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130373 - 130373

Published: Feb. 21, 2024

Language: Английский

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Epigallocatechin-3-gallate derived polymer coated Prussian blue for synergistic ROS elimination and antibacterial therapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124095 - 124095

Published: April 6, 2024

Language: Английский

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