Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
113(1)
Published: Dec. 30, 2024
Basic
fibroblast
growth
factor
(bFGF)
is
a
significant
member
of
the
(FGF)
family.
The
bFGF
has
three-dimensional
structure
comprising
12
reverse
parallel
β-folds.
This
facilitates
tissue
wound
repair,
angiogenesis,
bone
formation,
cartilage
and
nerve
regeneration.
Consequently,
it
garnered
attention
from
scholars
both
domestically
internationally.
However,
instability
degradation
properties
in
vivo
have
limited
its
clinical
application.
Significant
interest
arisen
development
novel
delivery
systems
that
can
address
shortcomings
enhance
bioavailability
by
controlling
release
amount,
timing,
location.
article
offers
comprehensive
overview
research
recent
advances
various
systems,
including
hydrogels,
liposomes,
microspheres,
nanoparticles.
Subsequently,
applications
pharmaceutical
preparations
fields
are
described.
Finally,
current
drug
formulations
those
trials
discussed,
along
with
their
translation
future
trends.
European Polymer Journal,
Journal Year:
2024,
Volume and Issue:
208, P. 112886 - 112886
Published: Feb. 28, 2024
Coaxial
electrospinning
is
a
commonly
used
technique
in
pharmaceutical
sciences
that
allows
producing
polymeric
nano-
or
microfibers
with
core-shell
structure.
In
addition
to
process
parameters
such
as
voltage
and
flow
rate
of
the
polymer
solutions,
properties
fibers
are
influenced
by
solution
including
total
concentration
ratio
between
fiber
core
shell.
As
these
typically
changed
empirically
during
development
methods,
there
lack
structured
studies
determine
optimal
settings
for
production
homogeneous,
mechanically
stable
fibers.
Therefore,
we
design
experiments
approach
systematically
address
coaxial
polycaprolactone,
biomaterials
applied
skin,
instance
form
patches
wound
healing
treatment
skin
cancer.
We
set
out
investigate
influence
different
on
morphology
(diameter
size
distribution)
well
their
mechanical
decisive
determinants
handling
efficacy
patches.
The
investigated
were
additionally
impact
presence
model
drug
hydrocortisone
outcome
release.
revealed
diameter
increases
increasing
concentration,
correlating
narrower
distribution.
addition,
our
results
show
higher
content
shell
leads
more
(higher
tensile
strength,
Young's
modulus).
Taken
together,
obtained
this
study
contribute
better
understanding
polycaprolactone.
ACS Applied Polymer Materials,
Journal Year:
2024,
Volume and Issue:
6(13), P. 7691 - 7704
Published: July 1, 2024
A
system
composed
of
ethylcellulose
(EC)
nanofibers
loading
with
[5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]zinc(II)
(TPPF20-Zn)
was
developed
as
electrospun
mats
to
contribute
the
inactivation
resistant
bacteria
strains.
This
tetrapyrrolic
macrocycle
chosen
for
its
excellent
photostability
and
straightforward
large-scale
preparation,
which
are
crucial
attributes
practical
applications.
The
synthesis
subsequent
characterization
TPPF20-Zn
demonstrated
scalability
ability
generate
reactive
oxygen
species
(ROS).
Subsequently,
nanofibrous
based
on
EC
loaded
different
amounts
porphyrin
were
obtained
using
single-nozzle
electrospinning
technique
after
dissolution
in
a
binary
solvent
mix
N,N-dimethylacetamide/ethanol.
fibers
exhibited
an
adequate
morphology
at
nanoscale,
narrow
diameter
distribution,
absence
beads.
Additionally,
thermal
surface
properties
systems
analyzed,
revealing
no
significant
changes
upon
incorporation.
composite
capability
photokill
Escherichia
coli,
confirmed
planktonic
suspension
advanced
fluorescence
microscopy.
Considering
all
studies
reported
herein,
we
believe
that
EC/TPPF20-Zn
show
promise
application
field
antimicrobial
patches
or
self-sterilizing
surfaces.
