Iterative Design Reveals Molecular Domain Relationships in Supramolecular Peptide–Drug Conjugates DOI

Matthew J. Sis,

Dongping Liu,

I. V. Allen

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(7), P. 4482 - 4491

Published: June 13, 2024

Supramolecular peptide-drug conjugates (sPDCs) are prepared by covalent attachment of a drug moiety to peptide motif programmed for one-dimensional self-assembly, with subsequent physical entanglement these fibrillar structures enabling formation nanofibrous hydrogels. This class prodrug materials presents an attractive platform mass-efficient and site-specific delivery therapeutic agents using discrete, single-component molecular design. However, continued challenge in sPDC development is elucidating relationships between supramolecular interactions their domains the resultant impacts on assembly outcomes material properties. Inclusion saturated alkyl segment alongside hydrophobic domain sPDCs could relieve some necessity ordered, prodrug-produg interactions. Accordingly, nine here iterate design variables amino acid sequence prodrug-alkyl block All molecules spontaneously formed hydrogels under physiological conditions, indicating less hindered thermodynamic path self-assembly relative previous prodrug-only designs. studies arrangement, formation, mechanical properties as well release profiles showed complex function resulting assemblies. Together, results indicate that intrinsically linked holistic coupled contributions from directing emergent materials.

Language: Английский

Therapeutic supramolecular polymers: Designs and applications DOI Creative Commons
Han Wang, Jason C. Mills, Boran Sun

et al.

Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 148, P. 101769 - 101769

Published: Dec. 2, 2023

Language: Английский

Citations

17
Iterative Design Reveals Molecular Domain Relationships in Supramolecular Peptide–Drug Conjugates DOI

Matthew J. Sis,

Dongping Liu,

I. V. Allen

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(7), P. 4482 - 4491

Published: June 13, 2024

Supramolecular peptide-drug conjugates (sPDCs) are prepared by covalent attachment of a drug moiety to peptide motif programmed for one-dimensional self-assembly, with subsequent physical entanglement these fibrillar structures enabling formation nanofibrous hydrogels. This class prodrug materials presents an attractive platform mass-efficient and site-specific delivery therapeutic agents using discrete, single-component molecular design. However, continued challenge in sPDC development is elucidating relationships between supramolecular interactions their domains the resultant impacts on assembly outcomes material properties. Inclusion saturated alkyl segment alongside hydrophobic domain sPDCs could relieve some necessity ordered, prodrug-produg interactions. Accordingly, nine here iterate design variables amino acid sequence prodrug-alkyl block All molecules spontaneously formed hydrogels under physiological conditions, indicating less hindered thermodynamic path self-assembly relative previous prodrug-only designs. studies arrangement, formation, mechanical properties as well release profiles showed complex function resulting assemblies. Together, results indicate that intrinsically linked holistic coupled contributions from directing emergent materials.

Language: Английский

Citations

2