Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 4927 - 4942
Published: Nov. 1, 2024
Abstract:
Heart
failure
(HF)
is
a
disease
with
high
morbidity
and
mortality
rates
worldwide
significantly
affects
human
health.
Currently,
the
treatment
options
for
HF
are
limited,
there
an
urgent
need
to
discover
new
therapeutic
targets
strategies.
Macrophages
innate
immune
cells
involved
in
development
of
HF.
They
play
crucial
role
maintaining
cardiac
homeostasis
regulating
stress.
Recently,
macrophages
have
received
increasing
attention
as
potential
treating
With
improvement
technological
means,
study
has
made
great
progress.
This
article
discusses
biological
functions
macrophage
phagocytosis,
response,
tissue
repair.
The
polarization,
pyroptosis,
autophagy,
apoptosis
macrophages,
deeply
pathogenesis
Modulation
phenotypic
changes
can
improve
immune-inflammation,
myocardial
fibrosis,
energy
metabolism,
apoptosis,
angiogenesis
Keywords:
heart
failure,
macrophage,
autophagy
Small,
Journal Year:
2024,
Volume and Issue:
20(45)
Published: July 30, 2024
Reactive
oxygen
species
(ROS)-dependent
monotherapy
usually
demonstrates
poor
therapeutic
outcomes,
due
to
the
accompanied
activation
of
protective
autophagy
in
tumor
cells,
which
results
ROS
tolerance
and
immune
suppression.
In
this
study,
a
bimetallic
electro-sensitizer,
Pt-Ir
NPs
is
constructed,
loaded
with
inhibitor
chloroquine
(Pt-Ir-CQ
NPs),
enhance
effectiveness
electrotherapy
by
inhibiting
activating
anti-tumor
responses.
This
novel
platform
unique
advantages,
particularly
treatment
hypoxic
immunosuppressive
tumors.
First,
electro-sensitizer
catalyzes
water
molecules
into
under
electric
field,
achieving
ablation
through
electrotoxicity.
Second,
incorporated
CQ
inhibits
induced
electrotherapy,
restoring
sensitivity
cells
thereby
enhancing
effects
electrotherapy.
Third,
Pt-Ir-CQ
functionality
antigen-presenting
immunogenic
autophagy,
synergistically
responses
along
cell
death
(ICD)
effect
study
provides
approach
for
effective
long-term
inhibition
solid
tumors
flexible
modulation
an
exogenous
field.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101220 - 101220
Published: Sept. 1, 2024
Ovarian
cancer
(OC)
is
one
of
the
leading
causes
death
from
malignancy
in
women
and
lacks
safe
efficient
treatment.
The
novel
biomaterial,
recombinant
humanized
collagen
type
III
(rhCOLIII),
has
been
reported
to
have
various
biological
functions,
but
its
role
OC
unclear.
This
study
aimed
reveal
function
mechanism
action
rhCOLIII
OC.
We
developed
an
injectable
human
(rhCOL)-derived
material
with
a
molecular
weight
45
kDa,
stable
triple
helix
structure,
high
biocompatibility,
water
solubility
biosafety.
anti-tumor
activity
was
comprehensively
evaluated
through
Experimental Hematology and Oncology,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Nov. 1, 2024
Developing
resistance
to
cancer
treatments
is
a
major
challenge,
often
leading
disease
recurrence
and
metastasis.
Understanding
the
underlying
mechanisms
of
therapeutic
critical
for
developing
effective
strategies.
O-GlcNAcylation,
post-translational
modification
that
adds
GlcNAc
from
donor
UDP-GlcNAc
serine
threonine
residues
proteins,
plays
crucial
role
in
regulating
protein
function
cellular
signaling,
which
are
frequently
dysregulated
cancer.
Similarly,
ubiquitination,
involves
attachment
ubiquitin
degradation,
cell
cycle
control,
DNA
repair.
The
interplay
between
O-GlcNAcylation
ubiquitination
associated
with
progression
treatment.
This
review
discusses
recent
discoveries
regarding
roles
resistance,
their
interactions,
potential
mechanisms.
It
also
explores
how
targeting
these
pathways
may
provide
new
opportunities
overcome
treatment
cancer,
offering
fresh
insights
directions
research
development.
