MedComm – Biomaterials and Applications,
Journal Year:
2024,
Volume and Issue:
3(4)
Published: Dec. 1, 2024
Abstract
With
the
development
of
nanosystems,
they
are
gradually
utilized
to
ameliorate
diverse
cancer
therapies.
Specifically
for
immunotherapy,
most
nanosystems
elaborately
designed
initiate
self‐sustaining
“cancer
immunity
cycle
(CIC)”
elicit
immune
response.
However,
owing
highly
complex
circulatory
environment,
may
face
issues
like
nonspecific
nanoparticle
uptake
and
rapid
clearance,
leaving
enormous
room
advancement.
For
employing
biomimetic
design
in
based
on
cell
membranes
(BNCMs)
inherit
various
functional
molecules
from
source
cells,
permitting
precise
tumor
targeting,
enhancing
blood
circulation,
conferring
more
desired
functionality
a
robust
To
take
full
advantage
BNCMs,
understanding
their
functions
immunotherapy
is
essential.
In
this
review,
unique
properties
BNCMs
derived
cells
main
preparation
strategies
introduced.
Subsequently,
recent
advances
improving
discussed
aspects
roles
particular
stages
CIC,
working
mechanisms
outer
highlighted.
Finally,
along
with
analysis
existing
bottlenecks
clinical
translation,
some
suggestions
future
put
forward.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 531 - 531
Published: April 12, 2024
Nanoparticle-based
drug
delivery
systems
hold
promise
for
cancer
treatment
by
enhancing
the
solubility
and
stability
of
anti-tumor
drugs.
Nonetheless,
challenges
inadequate
targeting
limited
biocompatibility
persist.
In
recent
years,
cell
membrane
nano-biomimetic
have
emerged
as
a
focal
point
research
development,
due
to
their
exceptional
traits,
including
precise
targeting,
low
toxicity,
good
biocompatibility.
This
review
outlines
categorization
advantages
bionic
nano-delivery
systems,
provides
an
introduction
preparation
methods,
assesses
applications
in
treatment,
chemotherapy,
gene
therapy,
immunotherapy,
photodynamic
photothermal
combination
therapy.
Notably,
delves
into
application
various
identifies
opportunities
future
advancement.
Embracing
membrane-coated
biomimetic
nanoparticles
presents
novel
unparalleled
avenue
personalized
tumor
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2071 - 2071
Published: Feb. 8, 2024
Nanoencapsulation
has
become
a
recent
advancement
in
drug
delivery,
enhancing
stability,
bioavailability,
and
enabling
controlled,
targeted
substance
delivery
to
specific
cells
or
tissues.
However,
traditional
nanoparticle
faces
challenges
such
as
short
circulation
time
immune
recognition.
To
tackle
these
issues,
cell
membrane-coated
nanoparticles
have
been
suggested
practical
alternative.
The
production
process
involves
three
main
stages:
lysis
membrane
fragmentation,
isolation,
coating.
Cell
membranes
are
typically
fragmented
using
hypotonic
with
homogenization
sonication.
Subsequent
fragments
isolated
through
multiple
centrifugation
steps.
Coating
can
be
achieved
extrusion,
sonication,
combination
of
both
methods.
Notably,
this
analysis
reveals
the
absence
universally
applicable
method
for
coating,
stages
differ
significantly
their
procedures.
This
review
explores
current
developments
approaches
nanoparticles,
highlighting
potential
an
effective
alternative
various
therapeutic
applications.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: April 23, 2024
Gliomas,
the
most
prevalent
primary
brain
tumors,
pose
considerable
challenges
due
to
their
heterogeneity,
intricate
tumor
microenvironment
(TME),
and
blood-brain
barrier
(BBB),
which
restrict
effectiveness
of
traditional
treatments
like
surgery
chemotherapy.
This
review
provides
an
overview
engineered
cell
membrane
technologies
in
glioma
therapy,
with
a
specific
emphasis
on
targeted
drug
delivery
modulation
immune
microenvironment.
study
investigates
progress
membranes,
encompassing
physical,
chemical,
genetic
alterations,
improve
across
BBB
effectively
target
gliomas.
The
examination
focuses
interaction
membrane-coated
nanoparticles
(ECM-NPs)
TME
gliomas,
emphasizing
potential
modulate
behavior
enhance
therapeutic
efficacy.
further
explores
involvement
ECM-NPs
immunomodulation
techniques,
highlighting
impact
reactions.
While
facing
obstacles
related
stability
manufacturing
scalability,
outlines
forthcoming
research
directions
focused
enhancing
performance.
underscores
promise
surpassing
conventional
constraints,
proposing
novel
approaches
for
efficacious
treatment.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 849 - 849
Published: June 22, 2024
The
state
of
well-being
and
health
our
body
is
regulated
by
the
fine
osmotic
biochemical
balance
established
between
cells
different
tissues,
organs,
systems.
Specific
districts
human
are
defined,
kept
in
correct
functioning,
and,
therefore,
protected
from
exogenous
or
endogenous
insults
both
mechanical,
physical,
biological
nature
presence
barrier
In
addition
to
placental
barrier,
which
even
acts
as
a
linker
two
organisms,
mother
fetus,
all
barriers,
including
blood-brain
(BBB),
blood-retinal
blood-nerve
blood-lymph
blood-cerebrospinal
fluid
operate
maintain
physiological
homeostasis
within
tissues
organs.
From
pharmaceutical
point
view,
most
challenging
undoubtedly
BBB,
since
its
notably
complicates
treatment
brain
disorders.
BBB
action
can
impair
delivery
chemical
drugs
biopharmaceuticals
into
brain,
reducing
their
therapeutic
efficacy
and/or
increasing
unwanted
bioaccumulation
surrounding
healthy
tissues.
Recent
nanotechnological
innovation
provides
advanced
biomaterials
ad
hoc
customized
engineering
functionalization
methods
able
assist
brain-targeted
drug
delivery.
this
context,
lipid
nanocarriers,
synthetic
(liposomes,
solid
nanoparticles,
nanoemulsions,
nanostructured
carriers,
niosomes,
proniosomes,
cubosomes)
cell-derived
ones
(extracellular
vesicles
cell
membrane-derived
nanocarriers),
considered
one
successful
systems
due
reasonable
biocompatibility
ability
cross
BBB.
This
review
aims
provide
complete
up-to-date
view
on
varied
whether
FDA-approved,
involved
clinical
trials,
used
vitro
vivo
studies,
for
inflammatory,
cancerous,
infectious
diseases.
Nanoencapsulation
has
emerged
as
a
recent
improvement
in
the
delivery
of
drugs,
offering
and
improving
stability
bioavailability,
allowing
for
controlled
targeted
substances
to
specific
cells
or
tissues.
However,
traditional
nanoparticle
faces
challenges
such
short
circulation
time
immune
recognition.
To
address
these
issues,
cell
membrane-coated
nanoparticles
have
been
proposed
promising
alternative.
The
production
involves
three
key
stages:
lysis
membrane
fragmentation,
isolation,
coating.
Typically,
membranes
are
fragmented
using
hypotonic
combination
with
homogenization
sonication.
Subsequent
fragments
isolated
through
multiple
centrifugation
steps.
coating
can
be
achieved
extrusion,
sonication,
both
methods.
This
analysis
shows
absence
universally
applicable
method
coating,
stages
exhibit
notable
differences
their
procedures.
Here
we
review
ongoing
developments
approaches
that
position
this
technology
alternative
effective
drug
many
other
therapeutic
applications.
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
372, P. 874 - 884
Published: July 10, 2024
Dexamethasone
(DEX)
has
been
demonstrated
to
inhibit
the
inflammatory
corneal
neovascularization
(CNV).
However,
therapeutic
efficacy
of
DEX
is
limited
by
poor
bioavailability
conventional
eye
drops
and
increased
risk
hormonal
glaucoma
cataract
associated
with
prolonged
frequent
usage.
To
address
these
limitations,
we
have
developed
a
novel
DEX-loaded,
reactive
oxygen
species
(ROS)-responsive,
controlled-release
nanogel,
termed
DEX@INHANGs.
This
advanced
nanogel
system
constructed
formation
supramolecular
host-guest
complexes
cyclodextrin
(CD)
adamantane
(ADA)
as
cross-linking
force.
The
introduction
ROS-responsive
material,
thioketal
(TK),
ensures
controlled
release
in
response
oxidative
stress,
characteristic
CNV.
Furthermore,
nanogel's
retention
on
surface
for
over
8
h
achieved
through
covalent
binding
integrin
β1
fusion
protein,
which
enhances
its
bioavailability.
Cytotoxicity
assays
that
DEX@INHANGs
was
not
notably
toxic
human
epithelial
cells
(HCECs).
effectively
angiogenesis
vitro.
In
rabbit
model
chemically
burned
eyes,
once-daily
topical
application
observed
suppress
These
results
collectively
indicate
nanomedicine
formulation
may
offer
promising
treatment
option
CNV,
offering
significant
advantages
such
reduced
dosing
frequency
enhanced
patient
compliance.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101607 - 101607
Published: March 5, 2025
Osteosarcoma
(OS)
is
the
most
prevalent
malignant
primary
bone
tumor,
predominantly
affecting
children
and
young
adults
between
ages
of
11
20.
OS
presents
huge
challenges
in
treatment
because
its
aggressive
nature
high
metastatic
potential.
Chemotherapeutic
drugs
have
attracted
considerable
interest
for
OS,
but
they
suffer
from
poor
targeting,
low
bioavailability,
severe
side
effects,
multi-drug
resistance
acquired
by
tumor.
Therefore,
it
imperative
to
develop
novel
therapeutic
tactics
that
can
improve
outcomes
while
minimizing
toxicity.
Bioinspired
nanoparticles,
designed
through
exploiting
or
simulating
biological
structures
processes,
provide
promising
strategies
OS.
In
this
review,
we
elaborate
on
properties
biomedical
applications
state-of-the-art
bioinspired
including
cell
membrane-based
exosome-based
protein
template-based
peptide
nanoparticles
management
