Injectable self-healing hydrogel as a rising therapeutic strategy for the loco-regional management of cancer

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105913 - 105913

Published: June 26, 2024

Language: Английский

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Polyphenolic Nanomedicine Regulating Mitochondria REDOX for Innovative Cancer Treatment

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 972 - 972

Published: July 23, 2024

Cancer remains a highly lethal disease globally. The approach centered on REDOX-targeted mitochondrial therapy for cancer has displayed notable benefits. Plant polyphenols exhibit strong REDOX and anticancer properties, particularly by affecting function, yet their structural instability low bioavailability hinder utility. To overcome this challenge, researchers have utilized the inherent physical chemical characteristics of derivatives to develop innovative nanomedicines targeting mitochondria. This review examines construction strategies properties various types polyphenol-based biological nanomedicine regulating mitochondria in recent years, such as polyphenol self-assembly, metal–phenol network, polyphenol–protein, polyphenol–hydrogel, polyphenol–chitosan, polyphenol–liposome. These polyphenolic incorporate enhanced features improved solubility, efficient photothermal conversion capability, regulation homeostasis, ion adsorption through diverse strategies. focus is how these promote ROS production mechanism inhibit cancer. Furthermore, it delves into benefits applications treatments, well challenges future research.

Language: Английский

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Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140442 - 140442

Published: Jan. 1, 2025

Language: Английский

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Photothermal treatment of prostate tumor with micellar indocyanine green and Napabucasin to co-ablate cancer cells and cancer stem cells

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113704 - 113704

Published: April 1, 2025

Language: Английский

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Advances in cancer diagnosis and therapy by alginate-based multifunctional hydrogels: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137707 - 137707

Published: Nov. 18, 2024

Language: Английский

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Intravascular Casting Radiopaque Hydrogel Systems for Transarterial Chemo/Cascade Catalytic/Embolization Therapy of Hepatocellular Carcinoma

Small, Journal Year: 2024, Volume and Issue: 20(46)

Published: Aug. 7, 2024

This paper introduces catheter-directed intravascular casting hydrogels for transarterial chemo/starvation/chemodynamic embolization (TACSCE) therapy of hepatocellular carcinoma (HCC). Comprising Mn ion-crosslinked hyaluronic acid-dopamine (HD) with glucose oxidase (for decomposition to H

Language: Английский

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Innovative theranostic hydrogels for targeted gastrointestinal cancer treatment

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 27, 2024

Gastrointestinal tumors are the main causes of death among patients. These mainly diagnosed in advanced stages and their response to therapy is unfavorable. In spite development conventional therapeutics including surgery, chemotherapy, radiotherapy immunotherapy, treatment these still challenging. As a result, new based on (nano)biotechnology have been introduced. Hydrogels polymeric 3D networks capable absorbing water swell with favorable biocompatibility. application hydrogels different human diseases, wide cancer has improved because potential drug gene delivery, boosting chemotherapy immunotherapy as well vaccines. The current review focuses role gastrointestinal tumors. provide delivery drugs (both natural or synthetic compounds co-delivery) along delivery. Along stimulate phototherapy (photothermal photodynamic therapy) suppression Besides, ability for induction immune-related cells such dendritic can boost immunotherapy. For more specific therapy, stimuli-responsive types thermo- pH-sensitive self-healing site Moreover, promising diagnosis, circulating tumor cell isolation detection biomarkers tumors, highlighting importance clinic. Hence, diagnostic therapeutic tools gastrointestimal

Language: Английский

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Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(23), P. 6082 - 6098

Published: Jan. 1, 2024

Radiofrequency ablation (RFA) is a commonly used minimally invasive treatment for hepatocellular carcinoma (HCC). However, incomplete radiofrequency (iRFA) promotes tumor progression and metastasis. There an urgent need to develop innovative strategies enhance the efficacy of iRFA. The upregulation heat shock proteins (HSPs) activation protective autophagy in cells upon exposure sublethal thermotolerance, thereby promoting cell survival. Here, 3-methyladenine (3-MA) lonidamine (LND) co-encapsulated liposomes (Lip@LND/3-MA) are designed iRFA by simultaneous inhibition glycolysis autophagy. On one hand, LND inhibits hexokinase, key enzyme glycolysis, thus reduces ATP production consequently suppresses expression HSPs. other 3-MA, as inhibitor, can inhibit after Lip@LND/3-MA confirmed suppress HSPs reduce level during RFA. Therefore, thermotolerance significantly weakened, leading remarkably enhanced therapeutic It believed that promising strategy clinical practice

Language: Английский

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NIR stimulated epigallocatechin gallate loaded polydopamine with enhanced antibacterial and ROS scavenging abilities for improved infectious wound healing

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110569 - 110569

Published: Oct. 1, 2024

Language: Английский

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Photoactive broad-spectrum dressings with antimicrobial and antitumoral properties

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 169, P. 214158 - 214158

Published: Dec. 20, 2024

Language: Английский

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