ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(43), P. 29421 - 29438
Published: Oct. 15, 2024
Over
the
past
decade,
a
marked
escalation
in
prevalence
of
hepatic
pathologies
has
been
observed,
adversely
impacting
quality
life
for
many.
The
predominant
therapeutic
strategy
liver
diseases
pharmacological
intervention;
however,
its
efficacy
is
often
constrained.
Currently,
liposomes
are
tiny
structures
that
can
deliver
drugs
directly
to
targeted
areas,
enhancing
their
effectiveness.
Specifically,
cell
membrane-associated
have
gained
significant
attention.
Despite
this,
there
still
much
learn
about
binding
mechanism
this
type
liposome.
Thus,
review
comprehensively
summarizes
relevant
information
on
liposomes,
including
clinical
applications
and
future
development
directions.
First,
we
will
briefly
introduce
composition
types
liposomes.
We
provide
an
overview
structure
discuss
various
associated
with
membranes.
Second,
thoroughly
strategies
drug
delivery
using
these
Lastly,
application
challenges
treating
diseases.
explore
potential
benefits
while
also
addressing
obstacles
need
be
overcome.
Furthermore,
prospects
field.
In
summary,
underscores
promise
disease
treatment
highlights
further
research
optimize
utilization.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Feb. 11, 2025
Abstract
Accumulated
evidence
has
implicated
the
diverse
and
substantial
influence
of
lactate
on
cellular
differentiation
fate
regulation
in
physiological
pathological
settings,
particularly
intricate
conditions
such
as
cancer.
Specifically,
been
demonstrated
to
be
pivotal
molding
tumor
microenvironment
(TME)
through
its
effects
different
cell
populations.
Within
cells,
impacts
signaling
pathways,
augments
shuttle
process,
boosts
resistance
oxidative
stress,
contributes
lactylation.
In
various
populations,
interplay
between
immune
cells
governs
processes
differentiation,
response,
surveillance,
treatment
effectiveness.
Furthermore,
communication
stromal/endothelial
supports
basal
membrane
(BM)
remodeling,
epithelial-mesenchymal
transitions
(EMT),
metabolic
reprogramming,
angiogenesis,
drug
resistance.
Focusing
production
transport,
specifically
dehydrogenase
(LDH)
monocarboxylate
transporters
(MCT),
shown
promise
Inhibitors
targeting
LDH
MCT
act
both
suppressors
enhancers
immunotherapy,
leading
a
synergistic
therapeutic
effect
when
combined
with
immunotherapy.
The
review
underscores
importance
progression
provides
valuable
perspectives
potential
approaches
that
target
vulnerability
metabolism,
highlighting
Heel
Achilles
for
cancer
treatment.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 5026 - 5036
Published: Aug. 12, 2024
Periodontitis
is
a
chronic
inflammatory
disease
marked
by
dysregulated
immune
microenvironment,
posing
formidable
challenges
for
effective
treatment.
The
characterized
an
altered
glucose
metabolism
in
macrophages,
specifically
increase
aerobic
glycolysis,
which
linked
to
heightened
responses.
This
suggests
that
targeting
macrophage
could
offer
new
therapeutic
avenue.
In
this
study,
we
developed
immunometabolic
intervention
using
quercetin
(Q)
encapsulated
bioadhesive
mesoporous
polydopamine
(Q@MPDA)
treat
periodontitis.
Our
results
demonstrated
Q@MPDA
reprogram
macrophages
anti-inflammatory
phenotype
(
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(3), P. 203 - 203
Published: March 16, 2025
Ovarian
cancer
(OC)
is
a
global
health
problem
that
frequently
presents
at
advanced
stages,
predisposed
to
recurrence,
readily
develops
resistance
platinum-based
drugs,
and
has
low
survival
rate.
Predictive,
preventive,
personalized
medicine
(PPPM/3PM)
offers
an
integrated
solution
with
the
use
of
genetic,
proteomic,
metabolic
biomarkers
identify
high-risk
individuals
for
early
detection.
Metabolic
reprogramming
one
key
strategies
employed
by
tumor
cells
adapt
microenvironment
support
unlimited
proliferation.
Pyruvate
kinases
M1
M2
(PKM1/2)
are
encoded
PKM
gene,
pivotal
enzyme
in
last
step
glycolytic
pathway,
which
crossroads
aerobic
oxidation
Warburg
effect
serve
as
potential
regulator
glucose
metabolism
influence
cellular
energy
production
reprogramming.
Commonly,
ratio
PKM1-to-PKM2
changed
tumors
compared
normal
controls,
PKM2
highly
expressed
OC
induce
high
glycolysis
rate
participate
malignant
invasion
metastatic
characteristics
epithelial/mesenchymal
transition
(EMT).
inhibitors
suppress
migration
growth
interfering
effect.
Proteoforms
final
structural
functional
forms
gene/protein,
canonical
protein
contains
all
proteoforms
same
gene.
The
complexity
can
be
elucidated
proteoformics.
OC-specific
proteoform
might
represent
specific
target
therapeutic
interventions
against
OC.
In
framework
PPPM/3PM,
warning
prognosis
biomarker.
It
important
clarify
molecular
mechanisms
metabolism.
This
review
analyzes
expression,
function,
OC,
help
