Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology, Journal Year: 2024, Volume and Issue: 18(4), P. 313 - 323
Published: Dec. 1, 2024
Language: Английский
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3
Published: Jan. 24, 2025
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
The immunomodulatory effects and excellent tolerability of polysaccharides make them optimal candidates for pulmonary vaccine adjuvants. Yet, the structure-immunostimulatory activity relationship remains unrevealed. Here, we developed nanovaccines decorated with four distinct structures─hyaluronic acid (HA), pectin (PC), chondroitin sulfate (SC), heparan (SH)─all sharing similar particle sizes zeta potential. Polysaccharides containing groups (SC, SH) exhibited superior efficacy in overcoming natural inhalation barriers recruiting dendritic cells (DC). DC stimulation assays revealed that HA SH significantly upregulated expression costimulation signals, IL-6 secretion rising over 8.7-fold compared to pure OVA. Fluorescence resonance energy transfer demonstrated their detachment within lysosomal microenvironment, thereby enhancing antigen cross-presentation. However, vivo findings only showed CCR7 chemokine swiftly migrated lymph nodes. Molecular docking Western blot analyses further elucidated involvement TLR─MyD88─TRAF6─NF-κB/MAPK/IRF-7 signaling pathways. Notably, SH-modified induced a more robust cellular humoral immune response potential memory. This study confirms enhance activation combining acetyl offers promising adjuvant configuration augmenting mucosal, cellular, immunity.
Language: Английский
Citations
1
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Aug. 31, 2024
Abstract Malignant tumors remain a primary cause of human mortality. Among the various treatment modalities for neoplasms, tumor vaccines have consistently shown efficacy and promising potential. These offer advantages such as specificity, safety, tolerability, with mRNA representing platforms. By introducing exogenous mRNAs encoding antigens into somatic cells subsequently synthesizing through gene expression systems, can effectively induce immune responses. Katalin Karikó Drew Weissman were awarded 2023 Nobel Prize in Physiology or Medicine their great contributions to vaccine research. Compared traditional vaccines, several advantages, including rapid preparation, reduced contamination, nonintegrability, high biodegradability. Tumor-targeted therapy is an innovative modality that enables precise targeting cells, minimizes damage normal tissues, safe at doses, demonstrates efficacy. Currently, targeted has become important option malignant tumors. The application tumor-targeted expanding, numerous clinical trials underway. We systematically outline delivery mechanism by which anti-tumor responses, describe current research applications therapy, forecast future development trends therapy.
Language: Английский
Citations
8
Current Drug Metabolism, Journal Year: 2024, Volume and Issue: 25(4), P. 248 - 265
Published: May 1, 2024
: Modern nanostructures must fulfill a wide range of functions to be valuable, leading the combi-nation various nano-objects into hierarchical assemblies. Hybrid Nanoparticles (HNPs), comprised mul-tiple types nanoparticles, are emerging as nanoscale structures with versatile applications. HNPs offer en-hanced medical benefits compared basic combinations distinct components. They address limitations traditional nanoparticle delivery systems, such poor water solubility, nonspecific targeting, and subopti-mal therapeutic outcomes. also facilitate transition from anatomical molecular imaging in lung cancer diagnosis, ensuring precision. In clinical settings, selection nanoplatforms superior repro-ducibility, cost-effectiveness, easy preparation, advanced functional structural characteristics is para-mount. This study aims toextensively examine hybrid focusing on their classification, drug de-livery mechanisms, properties inorganic advancements technol-ogy, biomedical applications, particularly emphasizing utilization smart nanoparticles. PHNPs enable numerous anticancer, anti-leishmanial, antifungal drugs, enhancing cellular absorption, bioavailability, targeted while reducing toxic side effects.
Language: Английский
Citations
4
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Contemporary osteoporosis treatment often neglects the intricate interactions among immune cells, signaling proteins, and cytokines within osteoporotic microenvironment. Here, we developed core-shell nanocapsules composed of a cationized lactoferrin core an alendronate polymer shell. By tuning size these leveraging shell, enabled precise delivery small interfering RNA targeting Semaphorin 4D gene (siSema4D) to specific bone sites. This strategy integrates antiresorptive drug with siSema4D, efficiently inhibiting osteoclast (OC) differentiation resorption, while promoting osteogenesis restore balance between osteoblasts (OBs) OCs. Moreover, encapsulating siSema4D helps mitigate immunological cascades, thereby reversing inflammatory microenvironment restoring homeostasis providing insights into immunomodulatory effects Sema4D in therapy. In both ovariectomized senile mouse models, local intramuscular administration effectively rectified imbalance skeletal systems, significantly enhancing overall efficacy treatment. Our findings underscore therapeutic promise addressing multifaceted through targeted interventions.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Abstract Intranasal delivery of mRNA vaccines offers promising opportunities to combat airborne viruses like SARS‐CoV‐2 by provoking mucosal immunity, which not only defends against respiratory infection but also prevents contagious transmission. However, the development nasal has been hampered lack effective means overcome mucus barrier. Herein, ionizable lipid‐incorporated liquid lipid nanoparticles (iLLNs) capable delivering cargo across airway mucosa are designed. Adjusting ratios and cationic lipids allows fine‐tuning p K a iLLNs range pH (5.5–6.5), thus facilitating penetration via formation near‐neutral, PEGylated muco‐inert surfaces. When nasally administered mice, top candidate iLLN‐2/mRNA complexes enable about 60‐fold greater reporter gene expression in cavity, compared benchmark mRNA‐lipid (ALC‐LNP) having same composition as that BNT162b2 vaccine. Moreover, prime‐boost intranasal immunization elicits magnitude spike‐specific IgA IgG response than ALC‐LNP, without triggering any noticeable inflammatory reactions. Taken together, these results provide useful insights for design deliverable formulations prophylactic applications.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 207 - 207
Published: Feb. 6, 2025
Poly(D,L-lactide-co-glycolide) (PLGA) has emerged as a cornerstone in the development of advanced drug delivery systems, particularly for intranasal and pulmonary routes. Its biodegradability, biocompatibility, adaptability make it an ideal platform addressing challenges associated with conventional therapies. By enabling sustained controlled release, PLGA formulations reduce dosing frequency, improve patient compliance, enhance therapeutic efficacy. These systems demonstrate versatility, accommodating hydrophilic hydrophobic drugs, biological molecules, co-delivery synergistic agents. Moreover, surface modifications preparation techniques targeting, bioavailability, stability, expanding PLGA’s applications to treat complex diseases such tuberculosis, cancer, fibrosis, CNS disorders. This manuscript provides in-depth review materials, properties, methods, applications, alongside critical evaluation future opportunities this field.
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114597 - 114597
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142743 - 142743
Published: April 1, 2025
Language: Английский
Citations
0