Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1188 - 1188
Published: Sept. 8, 2024
Skin
and
soft-tissue
infections
require
significant
consideration
because
of
their
prolonged
treatment
duration
propensity
to
rapidly
progress,
resulting
in
severe
complications.
The
primary
challenge
stems
from
the
involvement
drug-resistant
microorganisms
that
can
form
impermeable
biofilms,
as
well
possibility
infection
extending
deep
into
tissues,
thereby
complicating
drug
delivery.
Dissolving
microneedle
patches
are
an
innovative
transdermal
drug-delivery
system
effectively
enhances
penetration
through
stratum
corneum
barrier,
increasing
concentration
at
site
infection.
They
offer
highly
efficient,
safe,
patient-friendly
alternatives
conventional
topical
formulations.
This
comprehensive
review
focuses
on
recent
advances
emerging
trends
dissolving-microneedle
technology
for
antimicrobial
skin-infection
therapy.
Conventional
antibiotic
microneedles
compared
with
those
based
agents,
such
quorum-sensing
inhibitors,
peptides,
antimicrobial-matrix
materials.
also
highlights
potential
incorporating
chemodynamic,
nanoenzyme
antimicrobial,
photodynamic,
photothermal
antibacterial
therapies.
explores
advantages
various
therapies
emphasizes
combined
application
improve
efficacy
microneedles.
Finally,
this
analyzes
druggability
different
discusses
possible
future
developments.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 248 - 248
Published: Feb. 13, 2025
Obesity
has
become
a
major
public
health
threat,
as
it
can
cause
various
complications
such
diabetes,
cardiovascular
disease,
sleep
apnea,
cancer,
and
osteoarthritis.
The
primary
anti-obesity
therapies
include
dietary
control,
physical
exercise,
surgical
interventions,
drug
therapy;
however,
these
treatments
often
have
poor
therapeutic
efficacy,
significant
side
effects,
unavoidable
weight
rebound.
As
revolutionized
transdermal
delivery
system,
microneedles
(MNs)
been
increasingly
used
to
deliver
therapeutics
subcutaneous
adipose
tissue
or
targeted
absorption
sites,
significantly
enhancing
anti-obese
effects.
Nevertheless,
there
is
still
lack
of
review
comprehensively
summarize
the
latest
progress
MN-mediated
treatment
obesity.
This
provides
an
overview
application
MN
technology
in
obesity,
focusing
on
promote
browning
white
(WAT),
suppress
adipogenesis,
improve
metabolic
function.
In
addition,
this
presents
detailed
examples
integration
with
iontophoresis
(INT)
photothermal
therapy
(PTT)
penetration
into
deeper
dermis
exert
synergistic
Furthermore,
challenges
prospects
for
obesity
are
also
discussed,
which
helps
guide
design
optimization
MNs.
Overall,
insight
development
clinical
translation
European Journal of Pharmaceutics and Biopharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 114687 - 114687
Published: March 1, 2025
Dissolving
microneedles
(MNs)
are
promising
transdermal
drug
delivery
systems
that
can
effectively
increase
the
absorption
of
drugs.
They
bypass
first
layer
skin,
stratum
corneum
(SC)
and
deliver
drugs
directly
into
dermis,
by
dissolving
inside
interstitial
fluid
releasing
active.
The
traditional
ways
MN
fabrication
involve
primarily
micromolding,
which
basically
uses
silicone
molds.
Drugs
polymer
mixture
solutions
poured
these
molds
after
drying
arrays
carefully
removed.
In
present
study,
a
novel
molding
process
was
employed
to
fabricate
MNs
containing
rivastigmine
(RIV).
RIV
is
available
as
an
oral
tablet
patch.
patch
(Exelon®),
used
for
managing
Alzheimer's
symptoms
in
mild
moderate
dementia,
releases
only
about
50
%
its
content,
raising
concerns
dose
wastage,
environmental
impact,
patient
costs.
Thus,
selected
model
combining
processes,
Digital
Light
Processing
Free-D
Molding,
Vacuum
Compression
Molding
(VCM)
Technique
provided
MeltPrep®.
developed
were
evaluated
regarding
their
physiochemical
characteristics
ability
penetrate
skin
without
breaking
or
creating
fragments,
they
withstand
forces
up
600
N.
visualized
using
optical
microscopy,
SEM,
CLSM
examine
geometry,
surface
length
(0.708
mm).
Permeability
studies
verified
significantly
transportation
across
9-fold.
Histological
analysis
conducted
ensure
produced
safe
applications.
Overall,
study
suggests
molding,
combination
3D
printing
VCM
produce
effective
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 2710 - 2724
Published: April 9, 2024
In
the
current
study,
coated
microneedle
arrays
were
fabricated
by
means
of
digital
light
processing
(DLP)
printing.
Three
different
shapes
designed,
printed,
and
with
PLGA
particles
containing
two
actives.
Rivastigmine
(RIV)
N-acetyl-cysteine
(NAC)
coformulated
via
electrohydrodynamic
atomization
(EHDA),
they
incorporated
into
particles.
The
actives
are
administered
as
a
combined
therapy
for
Alzheimer's
disease.
printed
evaluated
regarding
their
ability
to
penetrate
skin
mechanical
properties.
Optical
microscopy
scanning
electron
(SEM)
employed
further
characterize
structure.
Confocal
laser
studies
conducted
construct
3D
imaging
coating
simulate
diffusion
through
artificial
samples.
Permeation
performed
investigate
transport
drugs
across
human
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(9), P. 4541 - 4552
Published: Aug. 1, 2024
Nanoparticle-loaded
dissolving
microneedles
(DMNs)
have
attracted
increasing
attention
due
to
their
ability
provide
high
drug
loading,
adjustable
release
behavior,
and
enhanced
therapeutic
efficiency.
However,
such
delivery
systems
still
face
unsatisfied
efficiency
insufficient
driving
force
promote
nanoparticle
penetration
the
lack
of
in
vivo
fate
studies
guide
formulation
design.
Herein,
an
aggregation-caused
quenching
(ACQ)
probe
(P4)
was
encapsulated
l-arginine
(l-Arg)-based
nanomicelles,
which
further
formulated
into
nitric
oxide
(NO)-propelled
nanomicelle-integrated
DMNs
(P4/l-Arg
NMs@DMNs)
investigate
biological
fate.
The
P4
could
emit
intense
fluorescence
signals
intact
while
with
dissociation
providing
a
"distinguishable"
method
for
tracking
nanomicelles
at
different
status.
l-Arg
demonstrated
self-generate
NO
under
tumor
microenvironment
excessive
reactive
oxygen
species
(ROS),
pneumatic
both
three-dimensional
(3D)-cultured
cells
melanoma-bearing
mice.
Compared
passive
(P4
without
propellant,
P4/l-Arg
NMs@DMNs
possessed
good
production
performance
higher
capacity.
In
conclusion,
this
study
offered
ACQ
probe-based
approach
demonstrate
potential
NO-propelled
nanoparticle-loaded
enhancement
topical
therapy.
