Oncology Reports,
Journal Year:
2024,
Volume and Issue:
53(2)
Published: Dec. 5, 2024
Ferroptosis
is
a
form
of
programmed
cell
death
that
distinct
from
apoptosis.
The
mechanism
involves
redox‑active
metallic
iron
and
characterized
by
an
abnormal
increase
in
iron‑dependent
lipid
reactive
oxygen
species,
which
results
high
levels
membrane
peroxides.
relationship
between
ferroptosis
gynaecological
tumours
complex.
can
regulate
tumour
proliferation,
metastasis
chemotherapy
resistance,
targeting
promising
antitumour
approach.
interacts
with
mechanisms
related
to
tumorigenesis
development,
such
as
macrophage
polarization,
the
neutrophil
trap
network,
mitochondrial
autophagy
cuproptosis.
present
review
examines
recent
information
on
interaction
molecular
other
tumour‑related
mechanisms,
well
involvement
tumours,
identify
implications
for
cancer
therapy.
Beilstein Journal of Nanotechnology,
Journal Year:
2025,
Volume and Issue:
16, P. 97 - 118
Published: Jan. 31, 2025
In
the
coming
decades,
development
of
nanocarriers
(NCs)
for
targeted
drug
delivery
will
mark
a
significant
advance
in
field
pharmacology.
NCs
can
improve
solubility,
ensure
precise
distribution,
and
enable
passage
across
biological
barriers.
Despite
these
potential
advantages,
interaction
with
many
matrices,
particularly
existing
macrophages,
must
be
considered.
this
review,
we
explore
dual
role
macrophages
NC
delivery,
highlighting
their
physiological
functions,
challenges
posed
by
mononuclear
phagocyte
system,
innovative
strategies
to
exploit
macrophage
interactions
therapeutic
advantage.
Recent
advancements
treating
liver
lung
diseases,
focusing
on
polarization
RNA-based
therapies,
have
highlighted
developments
macrophage-NC
interaction.
Furthermore,
delve
into
intriguing
nanomedicine
neurology
traumatology,
associated
interaction,
exciting
possibilities
it
holds
future.
Therapeutic Advances in Gastroenterology,
Journal Year:
2025,
Volume and Issue:
18
Published: Jan. 1, 2025
Inflammatory
bowel
disease
(IBD),
including
ulcerative
colitis
and
Crohn's
disease,
is
characterized
by
chronic
nonspecific
intestinal
inflammation.
Despite
considerable
efforts,
IBD
remains
a
heavy
burden
on
society
human
health,
with
increasing
morbidity.
Posttranslational
modification,
especially
histone
acetylation,
key
process
in
controlling
DNA
transcriptional
activity.
Histone
deacetylases
(HDACs)
play
vital
role
the
mechanism
of
pathogenesis
through
nonhistone
protein
deacetylation.
Herein,
we
present
summary
different
categories
HDACs
as
well
HDAC
inhibitors
(HDACis)
analyze
inhibition
alleviating
along
its
mechanism,
clinical
potential
HDACis
treatment.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2225 - 2240
Published: Feb. 1, 2025
Diabetes
mellitus
(DM)
remains
a
significant
health
challenge,
with
traditional
treatments
often
failing
to
provide
lasting
solutions.
Taxifolin
(Tax),
potential
phytomedicine
antioxidant
and
anti-hyperglycemic
properties,
suffers
from
low
water
solubility
poor
bioavailability,
necessitating
advanced
delivery
systems.
This
study
aims
nanometerize
taxifolin
(Tax)
into
selenized
liposomes
(Tax-Se@LPs)
for
enhanced
oral
hypoglycemic
effect.
Tax-Se@LPs
were
fabricated
through
thin-film
hydration/in
situ
reduction
technique.
The
resulting
nanomedicine
was
characterized
in
vitro
release
studies,
pharmacokinetic
pharmacodynamic
evaluations,
cellular
uptake
assays,
formulation
stability
tests.
optimized
demonstrated
an
average
particle
size
of
185.3
nm
entrapment
efficiency
95.25%
after
optimization.
In
studies
revealed
that
exhibited
slower
more
sustained
profile
compared
conventional
liposomes,
favoring
gastrointestinal
drug
absorption.
Pharmacokinetic
evaluations
normal
rats
indicated
achieved
relative
bioavailability
216.65%,
significantly
higher
than
Tax
suspensions
unmodified
liposomes.
Furthermore,
diabetic
GK
rats,
resulted
maximal
blood
glucose
46.8%
therapeutic
duration
other
formulations.
Cellular
tests
manifested
selenization
altered
the
internalization
mechanisms
while
preserving
their
absorption
aptness
by
intestinal
epithelial
cells.
physiological
also
reinforced
selenization.
Overall,
not
only
improve
but
enhance
its
efficacy.
These
findings
underscore
as
promising
strategy
DM
management.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 283 - 283
Published: Feb. 27, 2025
In
ginseng,
several
ginsenosides
have
been
demonstrated
to
alleviate
dextran
sulfate
sodium
(DSS)-induced
colitis,
especially
the
six
in
this
study.
However,
which
ginsenoside
has
most
potent
anti-inflammatory
effect
and
may
be
selected
as
a
promising
candidate
for
treatment
of
colitis
remains
unclear.
A
cell
inflammation
model
was
induced
by
lipopolysaccharide
(LPS)
12
h
mouse
sterile
water
containing
DSS
lasting
seven
days.
Cytokines
associated
with
inflammation,
pyroptosis,
ferroptosis
were
assessed
quantitative
real-time
PCR
(qPCR),
level
reactive
oxygen
species
(ROS)
changes
macrophage
polarization
tested
flow
cytometry,
analysis
intestinal
metabolites
LC-MS/MS
performed.
The
results
study
displayed
that
among
ginsenosides,
Rf,
Rg1,
Rg3
effective
reducing
LPS-induced
cells.
Compared
Rg1
superior
restoring
body
weight
length
colon,
decreasing
disease
activity
index
(DAI),
splenomegaly
colon
inflammation.
Meanwhile,
significantly
decreased
expression
M1-related
pro-inflammation
cytokines
increased
M2-related
anti-inflammation
cytokines.
also
CD86+M1
macrophages
polarized
them
towards
CD206+M2
macrophages.
700
targeted
gut
metabolite
assays
revealed
brought
composition
closer
DSS-naive
mice,
while
key
metabolites,
including
dodecanoylcarnitine,
isobutyric
acid,
decanoylcarnitine,
so
on,
all
reversed.
Our
had
extraordinary
cells
DSS-induced
and,
more
importantly,
it
blunted
through
regulating
metabolites.
Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 514 - 514
Published: March 30, 2025
The
uterine
smooth
muscle
(myometrium)
is
an
immunomodulatory
tissue
capable
of
secreting
multiple
chemokines
during
pregnancy.
We
propose
that
before
term
labor,
secreted
as
a
result
mechanical
stretch
the
walls
by
growing
fetus(es)
induce
infiltration
maternal
monocytes
into
myometrium,
drive
their
differentiation
macrophages,
and
pro-inflammatory
(M1)
polarization,
leading
to
labor
contractions.
This
study
used
high-throughput
proteomic
mass-spectrometry
investigate
underlying
mechanisms
explored
therapeutic
potential
broad-spectrum
chemokine
inhibitor
(BSCI,
FX125L)
in
modulating
these
effects.
Primary
myocytes
isolated
from
myometrium
pregnant
women
were
subjected
vitro
static
stretch.
Proteomic
analysis
stretched
myocyte-conditioned
media
(CM)
identified
significant
upregulation
chemokine-related
pathways
ECM
degradation
proteins.
CM
induced
human
macrophages
polarization
M1-like
phenotype
characterized
elevated
ROS
production.
BSCI
treatment
altered
myocyte
secretome,
increasing
tissue-remodeling
anti-inflammatory
proteins,
Annexin
A1
TGF-β.
BSCI-treated
secretions
expression
enhanced
phagocytic
activity.
conclude
factors
mechanically
M1
macrophage
while
modulates
which
reprograms
homeostatic
M2-like
phenotype,
thus
reducing
inflammation.
When
treated
with
BSCI,
M2-polarized
reduced
myocyte-driven
collagen
gel
contraction,
whereas
it.
reveals
novel
insights
myocyte–macrophage
interaction
identifies
promising
drug
modulate
myometrial
suggest
may
represent
target
for
preventing
preterm
women.
