Versatile hydrogel-based drug delivery platform for multimodal cancer therapy from bench to bedside

Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102341 - 102341

Published: July 22, 2024

Language: Английский

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Nano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.

Language: Английский

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Self-assembled nanoprobes for cancer phototheranostics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216643 - 216643

Published: April 18, 2025

Language: Английский

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Multifunctional ICG‐SB@Lip‐ZA Nanosystem Focuses on Remodeling the Inflammatory‐Immunosuppressive Microenvironment After Photothermal Therapy to Potentiate Cancer Photothermal Immunotherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Achieving full eradication of residual tumors post photothermal therapy (PTT) hinges on the immune system's activation and response. Nevertheless, resultant local inflammation attracts a significant influx aberrant cells fibroblasts, such as tumor-associated macrophages (TAMs) cancer-associated fibroblasts (CAFs), following tumor PTT. This phenomenon exacerbates evasion persistence cells, culminating in recurrence advancement. To tackle this challenge, combined therapeutic approach utilizing multifunctional ICG-SB@Lip-ZA nanosystem has been introduced. Indocyanine green (ICG) photothermal-transducer ablated zoledronic acid (ZA) depletes TAMs recruited by inflammatory microenvironment (mostly M2-like phenotype), SB-505124 affects CAFs proliferation (TME) inhibiting transforming growth factor-β （TGF-β） pathway, thereby removing physical barriers to T cell infiltration. In breast cancer model, these immunomodulatory nanoliposomes markedly decrease population TME, eliminate hindering infiltration, reshape immune-suppressive microenvironment, eventually leading rate 94%. (including conversion, TAM depletion, TGF-β pathway blockade) offers promising strategy for mitigating deteriorating PTT presents more efficient clinical photothermal-immune combination therapy.

Language: Английский

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Phased-Change Materials Based Immunomodulator for Cascade-Activatable Tumor-Specific Photoimmunotherapy

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(12), P. 5392 - 5401

Published: Nov. 9, 2024

The development of activatable immunomodulators for cancer treatment in a controlled and effective manner has been extensively pursued. However, the creation spatiotemporally controllable cascade-activatable tumor-specific photoimmunotherapy platform precise immunotherapy remains challenge. Herein, (CAI) are reported photoimmunotherapy. Under 808 nm irradiation, CAI not only mediates phototherapy effect to achieve tumor eradication immunogenic cell death but also triggers situ release caged toll-like receptor 7/8 R848-QPA. Additionally, intracellular NQO1 activates R848-QPA, leading cleavage trimethyl lock active R848 agonist, enhancing antitumor immune response. Such nanoimmunomodulator can effectively inhibit bilateral growth enhances systemic activation, resulting improved infiltration cytotoxic T lymphocytes helper cell. Therefore, this modular-designed engineered paradigm provides generic strategy developing immunotherapy.

Language: Английский

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Advances in Photothermal and Photodynamic Nanotheranostics for Precision Cancer Treatment

Journal of Nanotheranostics, Journal Year: 2024, Volume and Issue: 5(4), P. 228 - 252

Published: Dec. 13, 2024

Nanotheranostics, combining photothermal therapy (PTT) and photodynamic (PDT), can transform precision cancer treatment by integrating diagnosis into a single platform. This review highlights recent advances in nanomaterials, drug delivery systems, stimuli-responsive mechanisms for effective PTT PDT. Multifunctional nanoparticles enable targeted delivery, multimodal imaging, controlled release, overcoming the challenges posed tumor microenvironments. Emerging approaches such as hybrid therapies immune activation further enhance therapeutic efficacy. paper discusses limitations of nanotheranostics, including synthesis complexity limited tissue penetration, explores future directions toward biocompatible, scalable, clinically translatable solutions.

Language: Английский

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